6ejm - Revision history

OCA at 06:31, 20 June 2018

OCA — Wed, 20 Jun 2018 06:31:57 GMT

←Older revision		Revision as of 06:31, 20 June 2018
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	<StructureSection load='6ejm' size='340' side='right' caption='[[6ejm]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='6ejm' size='340' side='right' caption='[[6ejm]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ejm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ejm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dfw\|5dfw]], [[6ejg\|6ejg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dfw\|5dfw]], [[6ejg\|6ejg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD81, TAPA1, TSPAN28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejm OCA], [http://pdbe.org/6ejm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejm RCSB], [http://www.ebi.ac.uk/pdbsum/6ejm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejm OCA], [http://pdbe.org/6ejm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejm RCSB], [http://www.ebi.ac.uk/pdbsum/6ejm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejm ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Harris, S F]]		[[Category: Harris, S F]]
	[[Category: Kuglstatter, A]]		[[Category: Kuglstatter, A]]

OCA at 05:37, 30 May 2018

OCA — Wed, 30 May 2018 05:37:12 GMT

←Older revision		Revision as of 05:37, 30 May 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6ejm is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 5==
		+	<StructureSection load='6ejm' size='340' side='right' caption='[[6ejm]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ejm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJM FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5dfw\|5dfw]], [[6ejg\|6ejg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejm OCA], [http://pdbe.org/6ejm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejm RCSB], [http://www.ebi.ac.uk/pdbsum/6ejm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejm ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hepatitis C viral infection is the major cause of chronic hepatitis that affects as many as 71 million people worldwide. Rather than target the rapidly shifting viruses and their numerous serotypes, four independent antibodies were made to target the host antigen CD81 and were shown to block hepatitis C viral entry. The single-chain variable fragment of each antibody was crystallized in complex with the CD81 large extracellular loop in order to guide affinity maturation of two distinct antibodies by phage display. Affinity maturation of antibodies using phage display has proven to be critical to therapeutic antibody development and typically involves modification of the paratope for increased affinity, improved specificity, enhanced stability or a combination of these traits. One antibody was engineered for increased affinity for human CD81 large extracellular loop that equated to increased efficacy, while the second antibody was engineered for cross-reactivity with cynomolgus CD81 to facilitate animal model testing. The use of structures to guide affinity maturation library design demonstrates the utility of combining structural analysis with phage display technologies.

-	~~Authors~~:	+	Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.,Nelson B, Adams J, Kuglstatter A, Li Z, Harris SF, Liu Y, Bohini S, Ma H, Klumpp K, Gao J, Sidhu SS J Mol Biol. 2018 May 17. pii: S0022-2836(18)30434-0. doi:, 10.1016/j.jmb.2018.05.018. PMID:29778602<ref>PMID:29778602</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6ejm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Harris, S F]]
		+	[[Category: Kuglstatter, A]]
		+	[[Category: Villasenor, A]]
		+	[[Category: Antibody-antigen complex]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Helical bundle]]

OCA at 05:40, 11 October 2017

OCA — Wed, 11 Oct 2017 05:40:32 GMT

←Older revision		Revision as of 05:40, 11 October 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ejm is ON HOLD	+	The entry 6ejm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ejm" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 17:15:14 GMT

Protected "6ejm" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:15, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6ejm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 17:15:13 GMT

New page: '''Unreleased structure''' The entry 6ejm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ejm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]