6elu - Revision history

OCA at 07:08, 16 October 2019

OCA — Wed, 16 Oct 2019 07:08:01 GMT

←Older revision		Revision as of 07:08, 16 October 2019
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	==Structure of Serum Resistance Associated protein from T. b. rhodesiense==		==Structure of Serum Resistance Associated protein from T. b. rhodesiense==
-	<StructureSection load='6elu' size='340' side='right' caption='[[6elu]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='6elu' size='340' side='right'caption='[[6elu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6elu]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Trybr Trybr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6elu]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Trybr Trybr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELU FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Trybr]]		[[Category: Trybr]]

OCA at 07:19, 28 February 2018

OCA — Wed, 28 Feb 2018 07:19:11 GMT

←Older revision		Revision as of 07:19, 28 February 2018
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	<StructureSection load='6elu' size='340' side='right' caption='[[6elu]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6elu' size='340' side='right' caption='[[6elu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6elu]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6elu]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Trybr Trybr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elu OCA], [http://pdbe.org/6elu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elu RCSB], [http://www.ebi.ac.uk/pdbsum/6elu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elu ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31286 TRYBR])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elu OCA], [http://pdbe.org/6elu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elu RCSB], [http://www.ebi.ac.uk/pdbsum/6elu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
		+	[[Category: Trybr]]
	[[Category: Higgins, M K]]		[[Category: Higgins, M K]]
	[[Category: Zoll, S]]		[[Category: Zoll, S]]

OCA at 07:14, 31 January 2018

OCA — Wed, 31 Jan 2018 07:14:14 GMT

←Older revision		Revision as of 07:14, 31 January 2018
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elu OCA], [http://pdbe.org/6elu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elu RCSB], [http://www.ebi.ac.uk/pdbsum/6elu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elu ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elu OCA], [http://pdbe.org/6elu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elu RCSB], [http://www.ebi.ac.uk/pdbsum/6elu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elu ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2 (refs. (1,2)). These lipoprotein complexes contain an active, pore-forming component, apolipoprotein L1 (ApoL1), that causes trypanosome cell death (3) . One of the two human-infective subspecies, Trypanosoma brucei rhodesiense, differs from non-infective trypanosomes solely by the presence of the serum resistance-associated protein, which binds directly to ApoL1 and blocks its pore-forming capacity(3-5). Since this interaction is the single critical event that renders T. b. rhodesiense human- infective, detailed structural information that allows identification of binding determinants is crucial to understand immune escape by the parasite. Here, we present the structure of serum resistance-associated protein and reveal the adaptations that occurred as it diverged from other trypanosome surface molecules to neutralize ApoL1. We also present our mapping of residues important for ApoL1 binding, giving molecular insight into this interaction at the heart of human sleeping sickness.
		+
		+	The structure of serum resistance-associated protein and its implications for human African trypanosomiasis.,Zoll S, Lane-Serff H, Mehmood S, Schneider J, Robinson CV, Carrington M, Higgins MK Nat Microbiol. 2018 Jan 22. pii: 10.1038/s41564-017-0085-3. doi:, 10.1038/s41564-017-0085-3. PMID:29358741<ref>PMID:29358741</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6elu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:32, 24 January 2018

OCA — Wed, 24 Jan 2018 18:32:03 GMT

←Older revision		Revision as of 18:32, 24 January 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6elu is ~~ON HOLD~~	+	==Structure of Serum Resistance Associated protein from T. b. rhodesiense==
-		+	<StructureSection load='6elu' size='340' side='right' caption='[[6elu]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6elu]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELU FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elu OCA], [http://pdbe.org/6elu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elu RCSB], [http://www.ebi.ac.uk/pdbsum/6elu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Higgins, M K]]
		+	[[Category: Zoll, S]]
		+	[[Category: Antitoxin]]
		+	[[Category: Apolipoprotein li]]
		+	[[Category: Innate immune evasion]]
		+	[[Category: Sleeping sickness]]
		+	[[Category: Sra]]
		+	[[Category: Tryanosome]]
		+	[[Category: Trypanolytic factor]]

OCA: Protected "6elu" [edit=sysop:move=sysop]

OCA — Wed, 11 Oct 2017 05:41:46 GMT

Protected "6elu" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 11 October 2017

OCA: New page: '''Unreleased structure''' The entry 6elu is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Oct 2017 05:41:45 GMT

New page: '''Unreleased structure''' The entry 6elu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6elu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]