6en8 - Revision history

OCA at 06:48, 17 April 2019

OCA — Wed, 17 Apr 2019 06:48:05 GMT

←Older revision		Revision as of 06:48, 17 April 2019
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	==SaFadR in complex with dsDNA==		==SaFadR in complex with dsDNA==
-	<StructureSection load='6en8' size='340' side='right' caption='[[6en8]], [[Resolution\|resolution]] 3.29Å' scene=''>	+	<StructureSection load='6en8' size='340' side='right'caption='[[6en8]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6en8]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EN8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6en8]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulac Sulac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EN8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5mwr\|5mwr]], [[6el2\|6el2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5mwr\|5mwr]], [[6el2\|6el2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Saci_1107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330779 SULAC])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6en8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6en8 OCA], [http://pdbe.org/6en8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6en8 RCSB], [http://www.ebi.ac.uk/pdbsum/6en8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6en8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6en8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6en8 OCA], [http://pdbe.org/6en8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6en8 RCSB], [http://www.ebi.ac.uk/pdbsum/6en8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6en8 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fatty acid metabolism and its regulation are known to play important roles in bacteria and eukaryotes. By contrast, although certain archaea appear to metabolize fatty acids, the regulation of the underlying pathways in these organisms remains unclear. Here, we show that a TetR-family transcriptional regulator (FadRSa) is involved in regulation of fatty acid metabolism in the crenarchaeon Sulfolobus acidocaldarius. Functional and structural analyses show that FadRSa binds to DNA at semi-palindromic recognition sites in two distinct stoichiometric binding modes depending on the operator sequence. Genome-wide transcriptomic and chromatin immunoprecipitation analyses demonstrate that the protein binds to only four genomic sites, acting as a repressor of a 30-kb gene cluster comprising 23 open reading frames encoding lipases and beta-oxidation enzymes. Fatty acyl-CoA molecules cause dissociation of FadRSa binding by inducing conformational changes in the protein. Our results indicate that, despite its similarity in overall structure to bacterial TetR-family FadR regulators, FadRSa displays a different acyl-CoA binding mode and a distinct regulatory mechanism.
		+
		+	A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius.,Wang K, Sybers D, Maklad HR, Lemmens L, Lewyllie C, Zhou X, Schult F, Brasen C, Siebers B, Valegard K, Lindas AC, Peeters E Nat Commun. 2019 Apr 4;10(1):1542. doi: 10.1038/s41467-019-09479-1. PMID:30948713<ref>PMID:30948713</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6en8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Sulac]]
	[[Category: Valegard, K]]		[[Category: Valegard, K]]
	[[Category: Complex]]		[[Category: Complex]]

OCA at 06:52, 31 October 2018

OCA — Wed, 31 Oct 2018 06:52:08 GMT

←Older revision		Revision as of 06:52, 31 October 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6en8 ~~is ON HOLD~~	+	==SaFadR in complex with dsDNA==
-		+	<StructureSection load='6en8' size='340' side='right' caption='[[6en8]], [[Resolution\|resolution]] 3.29Å' scene=''>
-	~~Authors~~: ~~Valegard, K~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6en8]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EN8 FirstGlance]. <br>
-	~~Description~~: ~~SaFadR in complex with dsDNA~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5mwr\|5mwr]], [[6el2\|6el2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6en8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6en8 OCA], [http://pdbe.org/6en8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6en8 RCSB], [http://www.ebi.ac.uk/pdbsum/6en8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6en8 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Valegard, K]]		[[Category: Valegard, K]]
		+	[[Category: Complex]]
		+	[[Category: Dsdna]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription factor]]

OCA: Protected "6en8" [edit=sysop:move=sysop]

OCA — Wed, 11 Oct 2017 05:45:13 GMT

Protected "6en8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:45, 11 October 2017

OCA: New page: '''Unreleased structure''' The entry 6en8 is ON HOLD Authors: Valegard, K. Description: SaFadR in complex with dsDNA Category: Unreleased Structures Category: Valegard, K

OCA — Wed, 11 Oct 2017 05:45:12 GMT

New page: '''Unreleased structure''' The entry 6en8 is ON HOLD Authors: Valegard, K. Description: SaFadR in complex with dsDNA Category: Unreleased Structures Category: Valegard, K

New page

'''Unreleased structure'''

The entry 6en8 is ON HOLD

Authors: Valegard, K.

Description: SaFadR in complex with dsDNA
[[Category: Unreleased Structures]]
[[Category: Valegard, K]]