6eq0 - Revision history

OCA at 06:21, 6 June 2018

OCA — Wed, 06 Jun 2018 06:21:48 GMT

←Older revision		Revision as of 06:21, 6 June 2018
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	<StructureSection load='6eq0' size='340' side='right' caption='[[6eq0]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='6eq0' size='340' side='right' caption='[[6eq0]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eq0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eq0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6epy\|6epy]], [[6epz\|6epz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6epy\|6epy]], [[6epz\|6epz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SY94_4618 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=358 "Achromobacter radiobacter" (Beijerinck and van Delden 1902) Bergey et al. 1934])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eq0 OCA], [http://pdbe.org/6eq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eq0 RCSB], [http://www.ebi.ac.uk/pdbsum/6eq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eq0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eq0 OCA], [http://pdbe.org/6eq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eq0 RCSB], [http://www.ebi.ac.uk/pdbsum/6eq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eq0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:56, 11 April 2018

OCA — Wed, 11 Apr 2018 13:56:14 GMT

←Older revision		Revision as of 13:56, 11 April 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6eq0 is ~~ON HOLD until Paper~~ Publication	+	==Structure of the periplasmic binding protein (PBP) MelB (atu4661) in complex with galactose from agrobacterium tumefacien C58==
		+	<StructureSection load='6eq0' size='340' side='right' caption='[[6eq0]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6eq0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQ0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6epy\|6epy]], [[6epz\|6epz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eq0 OCA], [http://pdbe.org/6eq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eq0 RCSB], [http://www.ebi.ac.uk/pdbsum/6eq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eq0 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial plant pathogen Agrobacterium fabrum uses periplasmic binding proteins (PBPs) along with ABC transporters to import a wide variety of plant molecules as nutrients. Nonetheless, how A. fabrum acquires plant metabolites is incompletely understood. Using genetic approaches and affinity measurements, we identified here the PBP MelB and its transporter as being responsible for the uptake of the raffinose family of oligosaccharides (RFOs), which are the most widespread Dgalactose containing oligosaccharides in higher plants. We also found that the RFO precursor galactinol, recently described as a plant defense molecule, is imported into Agrobacterium via MelB with nanomolar range affinity. Structural analyses and binding mode comparisons of the X-ray structures of MelB in complex with raffinose, stachyose, galactinol, galactose and melibiose (a raffinose degradation product) revealed how MelB recognizes the nonreducing end galactose common to all these ligands and that MelB has a strong preference for a two-unit sugar ligand. Of note, MelB conferred a competitive advantage to A. fabrum in colonizing the rhizosphere of tomato plants. Our integrative work highlights the structural and functional characteristics of melibiose and galactinol assimilation by A. fabrum, leading to a competitive advantage for these bacteria in the rhizosphere. We propose that the PBP MelB, which is highly conserved among both symbionts and pathogens from Rhizobiace family, is a major trait in these bacteria required for early steps of plant colonization.

-	~~Authors~~:	+	The plant defense signal galactinol is specifically used as a nutrient by the bacterial pathogen Agrobacterium fabrum.,Meyer T, Vigouroux A, Aumont-Nicaise M, Comte G, Vial L, Lavire C, Morera S J Biol Chem. 2018 Mar 30. pii: RA118.001856. doi: 10.1074/jbc.RA118.001856. PMID:29602905<ref>PMID:29602905</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6eq0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Morera, S]]
		+	[[Category: Vigouroux, A]]
		+	[[Category: Protein transport associated to abc transporter]]
		+	[[Category: Transport protein]]

OCA: Protected "6eq0" [edit=sysop:move=sysop]

OCA — Wed, 25 Oct 2017 05:55:59 GMT

Protected "6eq0" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:55, 25 October 2017

OCA: New page: '''Unreleased structure''' The entry 6eq0 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Oct 2017 05:55:58 GMT

New page: '''Unreleased structure''' The entry 6eq0 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6eq0 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]