6eqo - Revision history

OCA at 12:21, 9 May 2024

OCA — Thu, 09 May 2024 12:21:04 GMT

←Older revision		Revision as of 12:21, 9 May 2024
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	==Tri-functional propionyl-CoA synthase of Erythrobacter sp. NAP1 with bound NADP+ and phosphomethylphosphonic acid adenylate ester==		==Tri-functional propionyl-CoA synthase of Erythrobacter sp. NAP1 with bound NADP+ and phosphomethylphosphonic acid adenylate ester==
-	<StructureSection load='6eqo' size='340' side='right' caption='[[6eqo]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='6eqo' size='340' side='right'caption='[[6eqo]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eqo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Erythrobacter_sp.~~_nap1~~ Erythrobacter sp. ~~nap1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EQO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eqo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Erythrobacter_sp._NAP1 Erythrobacter sp. NAP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EQO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene~~>, ~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NAP1_02725 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=237727 Erythrobacter sp. NAP1])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6eqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eqo OCA], [~~http~~://pdbe.org/6eqo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6eqo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6eqo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6eqo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eqo OCA], [https://pdbe.org/6eqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eqo RCSB], [https://www.ebi.ac.uk/pdbsum/6eqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eqo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A3WE14_9SPHN A3WE14_9SPHN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6eqo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6eqo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetyl-CoA synthetase 3D structures\|Acetyl-CoA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Erythrobacter sp. ~~nap1~~]]	+	[[Category: Erythrobacter sp. NAP1]]
-	[[Category: Bernhardsgruetter, I]]	+	[[Category: Large Structures]]
-	[[Category: Engilberge, S]]	+	[[Category: Bernhardsgruetter I]]
-	[[Category: Erb~~, T J~~]]	+	[[Category: Engilberge S]]
-	[[Category: Girard, E]]	+	[[Category: Erb TJ]]
-	[[Category: Shima, S]]	+	[[Category: Girard E]]
-	[[Category: Voegeli, B]]	+	[[Category: Shima S]]
-	[[Category: Wagner, T]]	+	[[Category: Voegeli B]]
-	[[Category: Zarzycki, J]]	+	[[Category: Wagner T]]
-	~~[[Category: 3-hydroxpropionyl-coa dehydratase]]~~	+	[[Category: Zarzycki J]]
-	~~[[Category: 3-hydroxpropionyl-coa synthetase]]~~	+
-	~~[[Category: 3-hydroxypropionate bi-cycle]]~~	+
-	~~[[Category: Acrylyl-coa reductase]]~~	+
-	~~[[Category: Carbon dioxode fixation]]~~	+
-	~~[[Category: Central carbon metabolism]]~~	+
-	~~[[Category: Natural fusion enzyme]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Substrate channeling~~]]	+

OCA at 12:46, 7 November 2018

OCA — Wed, 07 Nov 2018 12:46:58 GMT

←Older revision		Revision as of 12:46, 7 November 2018
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eqo OCA], [http://pdbe.org/6eqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eqo RCSB], [http://www.ebi.ac.uk/pdbsum/6eqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eqo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eqo OCA], [http://pdbe.org/6eqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eqo RCSB], [http://www.ebi.ac.uk/pdbsum/6eqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eqo ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cells must cope with toxic or reactive intermediates formed during metabolism. One coping strategy is to sequester reactions that produce such intermediates within specialized compartments or tunnels connecting different active sites. Here, we show that propionyl-CoA synthase (PCS), an approximately 400-kDa homodimer, three-domain fusion protein and the key enzyme of the 3-hydroxypropionate bi-cycle for CO2 fixation, sequesters its reactive intermediate acrylyl-CoA. Structural analysis showed that PCS forms a multicatalytic reaction chamber. Kinetic analysis suggested that access to the reaction chamber and catalysis are synchronized by interdomain communication. The reaction chamber of PCS features three active sites and has a volume of only 33 nm(3). As one of the smallest multireaction chambers described in biology, PCS may inspire the engineering of a new class of dynamically regulated nanoreactors.
		+
		+	The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite.,Bernhardsgrutter I, Vogeli B, Wagner T, Peter DM, Cortina NS, Kahnt J, Bange G, Engilberge S, Girard E, Riobe F, Maury O, Shima S, Zarzycki J, Erb TJ Nat Chem Biol. 2018 Oct 29. pii: 10.1038/s41589-018-0153-x. doi:, 10.1038/s41589-018-0153-x. PMID:30374166<ref>PMID:30374166</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6eqo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:15, 31 October 2018

OCA — Wed, 31 Oct 2018 07:15:40 GMT

←Older revision		Revision as of 07:15, 31 October 2018
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	<StructureSection load='6eqo' size='340' side='right' caption='[[6eqo]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6eqo' size='340' side='right' caption='[[6eqo]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eqo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eqo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Erythrobacter_sp._nap1 Erythrobacter sp. nap1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAP1_02725 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237727 Erythrobacter sp. NAP1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eqo OCA], [http://pdbe.org/6eqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eqo RCSB], [http://www.ebi.ac.uk/pdbsum/6eqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eqo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eqo OCA], [http://pdbe.org/6eqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eqo RCSB], [http://www.ebi.ac.uk/pdbsum/6eqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eqo ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Erythrobacter sp. nap1]]
	[[Category: Bernhardsgruetter, I]]		[[Category: Bernhardsgruetter, I]]
	[[Category: Engilberge, S]]		[[Category: Engilberge, S]]

OCA at 05:55, 24 October 2018

OCA — Wed, 24 Oct 2018 05:55:20 GMT

←Older revision		Revision as of 05:55, 24 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6eqo is ON HOLD until Paper Publication~~	+	==Tri-functional propionyl-CoA synthase of Erythrobacter sp. NAP1 with bound NADP+ and phosphomethylphosphonic acid adenylate ester==
-		+	<StructureSection load='6eqo' size='340' side='right' caption='[[6eqo]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~Authors: Zarzycki, J., Bernhardsgruetter, I., Voegeli, B., Wagner, T., Engilberge, S., Girard, E., Shima, S., Erb, T.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6eqo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQO FirstGlance]. <br>
-	~~Description:~~ Tri-functional propionyl-CoA synthase of Erythrobacter sp. NAP1 with bound NADP+ and phosphomethylphosphonic acid adenylate ester	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eqo OCA], [http://pdbe.org/6eqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eqo RCSB], [http://www.ebi.ac.uk/pdbsum/6eqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eqo ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Shima, S~~]]	+	</table>
-	[[~~Category~~: ~~Wagner~~, T]]	+	__TOC__
		+	</StructureSection>
	[[Category: Bernhardsgruetter, I]]		[[Category: Bernhardsgruetter, I]]
		+	[[Category: Engilberge, S]]
		+	[[Category: Erb, T J]]
	[[Category: Girard, E]]		[[Category: Girard, E]]
		+	[[Category: Shima, S]]
	[[Category: Voegeli, B]]		[[Category: Voegeli, B]]
-	[[Category: ~~Erb~~, T.J]]	+	[[Category: Wagner, T]]
	[[Category: Zarzycki, J]]		[[Category: Zarzycki, J]]
-	[[Category: ~~Engilberge, S~~]]	+	[[Category: 3-hydroxpropionyl-coa dehydratase]]
		+	[[Category: 3-hydroxpropionyl-coa synthetase]]
		+	[[Category: 3-hydroxypropionate bi-cycle]]
		+	[[Category: Acrylyl-coa reductase]]
		+	[[Category: Carbon dioxode fixation]]
		+	[[Category: Central carbon metabolism]]
		+	[[Category: Natural fusion enzyme]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Substrate channeling]]

OCA at 05:03, 1 November 2017

OCA — Wed, 01 Nov 2017 05:03:35 GMT

←Older revision		Revision as of 05:03, 1 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6eqo is ON HOLD	+	The entry 6eqo is ON HOLD until Paper Publication

	Authors: Zarzycki, J., Bernhardsgruetter, I., Voegeli, B., Wagner, T., Engilberge, S., Girard, E., Shima, S., Erb, T.J.		Authors: Zarzycki, J., Bernhardsgruetter, I., Voegeli, B., Wagner, T., Engilberge, S., Girard, E., Shima, S., Erb, T.J.

-	Description: Tri-functional propionyl-CoA synthase of Erythrobacter sp NAP1 with bound NADP+ and ~~adenosine-5'-[beta, gamma-methylene]triphosphate~~	+	Description: Tri-functional propionyl-CoA synthase of Erythrobacter sp. NAP1 with bound NADP+ and phosphomethylphosphonic acid adenylate ester
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Shima, S]]		[[Category: Shima, S]]
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	[[Category: Bernhardsgruetter, I]]		[[Category: Bernhardsgruetter, I]]
	[[Category: Girard, E]]		[[Category: Girard, E]]
		+	[[Category: Voegeli, B]]
	[[Category: Erb, T.J]]		[[Category: Erb, T.J]]
	[[Category: Zarzycki, J]]		[[Category: Zarzycki, J]]
-	[[Category: Voegeli, B]]
	[[Category: Engilberge, S]]		[[Category: Engilberge, S]]

OCA: Protected "6eqo" [edit=sysop:move=sysop]

OCA — Wed, 25 Oct 2017 05:57:05 GMT

Protected "6eqo" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:57, 25 October 2017

OCA: New page: '''Unreleased structure''' The entry 6eqo is ON HOLD Authors: Zarzycki, J., Bernhardsgruetter, I., Voegeli, B., Wagner, T., Engilberge, S., Girard, E., Shima, S., Erb, T.J. Description...

OCA — Wed, 25 Oct 2017 05:57:04 GMT

New page: '''Unreleased structure''' The entry 6eqo is ON HOLD Authors: Zarzycki, J., Bernhardsgruetter, I., Voegeli, B., Wagner, T., Engilberge, S., Girard, E., Shima, S., Erb, T.J. Description...

New page

'''Unreleased structure'''

The entry 6eqo is ON HOLD

Authors: Zarzycki, J., Bernhardsgruetter, I., Voegeli, B., Wagner, T., Engilberge, S., Girard, E., Shima, S., Erb, T.J.

Description: Tri-functional propionyl-CoA synthase of Erythrobacter sp NAP1 with bound NADP+ and adenosine-5'-[beta, gamma-methylene]triphosphate
[[Category: Unreleased Structures]]
[[Category: Shima, S]]
[[Category: Wagner, T]]
[[Category: Bernhardsgruetter, I]]
[[Category: Girard, E]]
[[Category: Erb, T.J]]
[[Category: Zarzycki, J]]
[[Category: Voegeli, B]]
[[Category: Engilberge, S]]