6erl - Revision history

OCA at 10:44, 14 June 2023

OCA — Wed, 14 Jun 2023 10:44:01 GMT

←Older revision		Revision as of 10:44, 14 June 2023
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	==Quadruplex with flipped tetrad formed by the c-myc promoter sequence==		==Quadruplex with flipped tetrad formed by the c-myc promoter sequence==
-	<StructureSection load='6erl' size='340' side='right'caption='[[6erl~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='6erl' size='340' side='right'caption='[[6erl]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6erl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ERL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6erl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ERL FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6erl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6erl OCA], [~~http~~://pdbe.org/6erl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6erl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6erl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6erl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6erl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6erl OCA], [https://pdbe.org/6erl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6erl RCSB], [https://www.ebi.ac.uk/pdbsum/6erl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6erl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Karg, B]]	+	[[Category: Karg B]]
-	[[Category: Weisz, K]]	+	[[Category: Weisz K]]
-	~~[[Category: 8-bromo-guanosine]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: G4]]~~	+
-	~~[[Category: Quadruplex]]~~	+
-	~~[[Category: Tetrad flip~~]]	+

OCA at 13:24, 10 May 2019

OCA — Fri, 10 May 2019 13:24:42 GMT

←Older revision		Revision as of 13:24, 10 May 2019
Line 1:		Line 1:

	==Quadruplex with flipped tetrad formed by the c-myc promoter sequence==		==Quadruplex with flipped tetrad formed by the c-myc promoter sequence==
-	<StructureSection load='6erl' size='340' side='right' caption='[[6erl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='6erl' size='340' side='right'caption='[[6erl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6erl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERL FirstGlance]. <br>		<table><tr><td colspan='2'>[[6erl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERL FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Karg, B]]		[[Category: Karg, B]]
	[[Category: Weisz, K]]		[[Category: Weisz, K]]

OCA at 07:41, 14 June 2018

OCA — Thu, 14 Jun 2018 07:41:24 GMT

←Older revision		Revision as of 07:41, 14 June 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6erl is ~~ON HOLD~~	+	==Quadruplex with flipped tetrad formed by the c-myc promoter sequence==
		+	<StructureSection load='6erl' size='340' side='right' caption='[[6erl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6erl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERL FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6erl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6erl OCA], [http://pdbe.org/6erl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6erl RCSB], [http://www.ebi.ac.uk/pdbsum/6erl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6erl ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A G-quadruplex forming sequence from the MYC promoter region was modified with syn-favoring 8-bromo-2'-deoxyguanosine residues. Depending on the number and position of modifications in the intramolecular parallel G-quadruplex, substitutions with the bromoguanosine analog at the 5'-tetrad induce conformational rearrangements with concerted all-anti to all-syn transitions for all residues of the modified G-quartet. No unfavorable steric interactions of the C8-substituents in the medium grooves are apparent in the high-resolution structure as determined for a tetrasubstituted MYC quadruplex that exclusively forms the all-syn isomer. In contrast, considerable steric clashes with 5'-phosphate oxygen atoms for those analogs that follow a less flexible 1-nucleotide loop in the native all-anti conformation seem to constitute the major driving force for the tetrad inversion and allow for the rational design of appropriately substituted sequences. Correlations found between the population of species subjected to a tetrad flip and melting temperatures indicate that more effective conformational transitions are compromised by lower thermal stabilities of the modified parallel quadruplexes.

-	~~Authors: Karg~~, B., Weisz, K.	+	Loop Length Affects Syn-Anti Conformational Rearrangements in Parallel G-Quadruplexes.,Karg B, Weisz K Chemistry. 2018 May 14. doi: 10.1002/chem.201801851. PMID:29756658<ref>PMID:29756658</ref>

-	~~Description: Quadruplex with flipped tetrad formed by~~ the ~~c-myc promoter sequence~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6erl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Karg, B]]		[[Category: Karg, B]]
	[[Category: Weisz, K]]		[[Category: Weisz, K]]
		+	[[Category: 8-bromo-guanosine]]
		+	[[Category: Dna]]
		+	[[Category: G4]]
		+	[[Category: Quadruplex]]
		+	[[Category: Tetrad flip]]

OCA: Protected "6erl" [edit=sysop:move=sysop]

OCA — Wed, 25 Oct 2017 06:02:53 GMT

Protected "6erl" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:02, 25 October 2017

OCA: New page: '''Unreleased structure''' The entry 6erl is ON HOLD Authors: Karg, B., Weisz, K. Description: Quadruplex with flipped tetrad formed by the c-myc promoter sequence [[Category: Unreleas...

OCA — Wed, 25 Oct 2017 06:02:52 GMT

New page: '''Unreleased structure''' The entry 6erl is ON HOLD Authors: Karg, B., Weisz, K. Description: Quadruplex with flipped tetrad formed by the c-myc promoter sequence [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 6erl is ON HOLD

Authors: Karg, B., Weisz, K.

Description: Quadruplex with flipped tetrad formed by the c-myc promoter sequence
[[Category: Unreleased Structures]]
[[Category: Karg, B]]
[[Category: Weisz, K]]