6es8 - Revision history

OCA at 06:27, 7 October 2020

OCA — Wed, 07 Oct 2020 06:27:04 GMT

←Older revision		Revision as of 06:27, 7 October 2020
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	==HIV capsid hexamer with IP6 ligand==		==HIV capsid hexamer with IP6 ligand==
-	<StructureSection load='6es8' size='340' side='right' caption='[[6es8]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='6es8' size='340' side='right'caption='[[6es8]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6es8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ES8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ES8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6es8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ES8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ES8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6es8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6es8 OCA], [http://pdbe.org/6es8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6es8 RCSB], [http://www.ebi.ac.uk/pdbsum/6es8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6es8 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6es8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6es8 OCA], [http://pdbe.org/6es8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6es8 RCSB], [http://www.ebi.ac.uk/pdbsum/6es8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6es8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6es8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6es8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: James, L C]]		[[Category: James, L C]]
	[[Category: Hiv]]		[[Category: Hiv]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 16:20, 15 August 2018

OCA — Wed, 15 Aug 2018 16:20:16 GMT

←Older revision		Revision as of 16:20, 15 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6es8 is ~~ON HOLD~~	+	==HIV capsid hexamer with IP6 ligand==
		+	<StructureSection load='6es8' size='340' side='right' caption='[[6es8]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6es8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ES8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ES8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6es8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6es8 OCA], [http://pdbe.org/6es8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6es8 RCSB], [http://www.ebi.ac.uk/pdbsum/6es8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6es8 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP6, transforming viral stability from minutes to hours and allowing newly synthesised DNA to accumulate inside the capsid. An arginine ring within the pore coordinates IP6, which strengthens capsid hexamers by almost 10 degrees C. Single molecule measurements demonstrate that this renders native HIV capsids highly stable and protected from spontaneous collapse. Moreover, encapsidated reverse transcription assays reveal that, once stabilised by IP6, the accumulation of new viral DNA inside the capsid increases >100 fold. Remarkably, isotopic labelling of inositol in virus-producing cells reveals that HIV selectively packages over 300 IP6 molecules per infectious virion. We propose that HIV recruits IP6 to regulate capsid stability and uncoating, analogous to picornavirus pocket factors. HIV-1/IP6/capsid/co-factor/reverse transcription.

-	~~Authors: James~~, L.C.	+	IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.,Mallery DL, Marquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Bocking T, James LC Elife. 2018 May 31;7. pii: 35335. doi: 10.7554/eLife.35335. PMID:29848441<ref>PMID:29848441</ref>

-	~~Description~~: ~~HIV capsid hexamer with IP6 ligand~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~James, L.C~~]]	+	<div class="pdbe-citations 6es8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: James, L C]]
		+	[[Category: Hiv]]
		+	[[Category: Viral protein]]

OCA at 19:59, 9 August 2018

OCA — Thu, 09 Aug 2018 19:59:24 GMT

←Older revision		Revision as of 19:59, 9 August 2018
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	The entry 6es8 is ON HOLD		The entry 6es8 is ON HOLD

-	Authors: ~~James, L.C.,~~ James, L.C.	+	Authors: James, L.C.

	Description: HIV capsid hexamer with IP6 ligand		Description: HIV capsid hexamer with IP6 ligand
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: James, L.C]]		[[Category: James, L.C]]

OCA at 05:44, 18 July 2018

OCA — Wed, 18 Jul 2018 05:44:21 GMT

←Older revision		Revision as of 05:44, 18 July 2018
Line 3:		Line 3:
	The entry 6es8 is ON HOLD		The entry 6es8 is ON HOLD

-	Authors: James, L.C.	+	Authors: James, L.C., James, L.C.

-	Description: ~~Hexamer~~ with ~~phosphate~~ ligand	+	Description: HIV capsid hexamer with IP6 ligand
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: James, L.C]]		[[Category: James, L.C]]

OCA at 04:12, 11 July 2018

OCA — Wed, 11 Jul 2018 04:12:46 GMT

←Older revision		Revision as of 04:12, 11 July 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6es8 is ON HOLD ~~until sometime in the future~~	+	The entry 6es8 is ON HOLD

	Authors: James, L.C.		Authors: James, L.C.

OCA: Protected "6es8" [edit=sysop:move=sysop]

OCA — Wed, 25 Oct 2017 06:07:56 GMT

Protected "6es8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:07, 25 October 2017

OCA: New page: '''Unreleased structure''' The entry 6es8 is ON HOLD until sometime in the future Authors: James, L.C. Description: Hexamer with phosphate ligand Category: Unreleased Structures [[...

OCA — Wed, 25 Oct 2017 06:07:55 GMT

New page: '''Unreleased structure''' The entry 6es8 is ON HOLD until sometime in the future Authors: James, L.C. Description: Hexamer with phosphate ligand Category: Unreleased Structures [[...

New page

'''Unreleased structure'''

The entry 6es8 is ON HOLD until sometime in the future

Authors: James, L.C.

Description: Hexamer with phosphate ligand
[[Category: Unreleased Structures]]
[[Category: James, L.C]]