6esh - Revision history

OCA at 00:32, 11 April 2020

OCA — Sat, 11 Apr 2020 00:32:46 GMT

←Older revision		Revision as of 00:32, 11 April 2020
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	<SX load='6esh' size='340' side='right' viewer='molstar' caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>		<SX load='6esh' size='340' side='right' viewer='molstar' caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ESH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ESH FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hist1h2aj, LOC494591 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hist1h2aj, LOC494591 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6esh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6esh OCA], [http://pdbe.org/6esh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6esh RCSB], [http://www.ebi.ac.uk/pdbsum/6esh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6esh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6esh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6esh OCA], [http://pdbe.org/6esh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6esh RCSB], [http://www.ebi.ac.uk/pdbsum/6esh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6esh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:09, 6 March 2020

OCA — Fri, 06 Mar 2020 21:09:53 GMT

←Older revision		Revision as of 21:09, 6 March 2020
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	==Nucleosome breathing : Class 3==		==Nucleosome breathing : Class 3==
-	<~~StructureSection~~ load='6esh' size='340' side='right'caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>	+	<SX load='6esh' size='340' side='right' viewer='molstar' caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ESH FirstGlance]. <br>		<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ESH FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: African clawed frog]]		[[Category: African clawed frog]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 11:03, 2 October 2019

OCA — Wed, 02 Oct 2019 11:03:19 GMT

←Older revision		Revision as of 11:03, 2 October 2019
Line 1:		Line 1:

	==Nucleosome breathing : Class 3==		==Nucleosome breathing : Class 3==
-	<StructureSection load='6esh' size='340' side='right' caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>	+	<StructureSection load='6esh' size='340' side='right'caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ESH FirstGlance]. <br>		<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ESH FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 6esh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6esh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone 3D structures\|Histone 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: African clawed frog]]		[[Category: African clawed frog]]
		+	[[Category: Large Structures]]
	[[Category: Bilokapic, S]]		[[Category: Bilokapic, S]]
	[[Category: Halic, M]]		[[Category: Halic, M]]

OCA at 20:57, 24 January 2018

OCA — Wed, 24 Jan 2018 20:57:41 GMT

←Older revision		Revision as of 20:57, 24 January 2018
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.		[[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nucleosomes, the basic units of chromatin, package and regulate expression of eukaryotic genomes. Although the structure of the intact nucleosome is well characterized, little is known about structures of partially unwrapped, transient intermediates. In this study, we present nine cryo-EM structures of distinct conformations of nucleosome and subnucleosome particles. These structures show that initial DNA breathing induces conformational changes in the histone octamer, particularly in histone H3, that propagate through the nucleosome and prevent symmetrical DNA opening. Rearrangements in the H2A-H2B dimer strengthen interaction with the unwrapping DNA and promote nucleosome stability. In agreement with this, cross-linked H2A-H2B that cannot accommodate unwrapping of the DNA is not stably maintained in the nucleosome. H2A-H2B release and DNA unwrapping occur simultaneously, indicating that DNA is essential in stabilizing the dimer in the nucleosome. Our structures reveal intrinsic nucleosomal plasticity that is required for nucleosome stability and might be exploited by extrinsic protein factors.
		+
		+	Histone octamer rearranges to adapt to DNA unwrapping.,Bilokapic S, Strauss M, Halic M Nat Struct Mol Biol. 2018 Jan;25(1):101-108. doi: 10.1038/s41594-017-0005-5. Epub, 2017 Dec 11. PMID:29323273<ref>PMID:29323273</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6esh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:01, 27 December 2017

OCA — Wed, 27 Dec 2017 09:01:23 GMT

←Older revision		Revision as of 09:01, 27 December 2017
Line 3:		Line 3:
	<StructureSection load='6esh' size='340' side='right' caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>		<StructureSection load='6esh' size='340' side='right' caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ESH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ESH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6esh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6esh OCA], [http://pdbe.org/6esh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6esh RCSB], [http://www.ebi.ac.uk/pdbsum/6esh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6esh ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hist1h2aj, LOC494591 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6esh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6esh OCA], [http://pdbe.org/6esh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6esh RCSB], [http://www.ebi.ac.uk/pdbsum/6esh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6esh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: African clawed frog]]
	[[Category: Bilokapic, S]]		[[Category: Bilokapic, S]]
	[[Category: Halic, M]]		[[Category: Halic, M]]

OCA at 06:27, 20 December 2017

OCA — Wed, 20 Dec 2017 06:27:39 GMT

←Older revision		Revision as of 06:27, 20 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6esh ~~is ON HOLD~~	+	==Nucleosome breathing : Class 3==
-		+	<StructureSection load='6esh' size='340' side='right' caption='[[6esh]], [[Resolution\|resolution]] 5.10Å' scene=''>
-	~~Authors~~: ~~Bilokapic~~, S., ~~Halic~~, M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6esh]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ESH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ESH FirstGlance]. <br>
-	~~Description~~: ~~Nucleosome breathing~~ : ~~Class 3~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6esh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6esh OCA], [http://pdbe.org/6esh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6esh RCSB], [http://www.ebi.ac.uk/pdbsum/6esh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6esh ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bilokapic, S]]
	[[Category: Halic, M]]		[[Category: Halic, M]]
-	[[Category: ~~Bilokapic, S~~]]	+	[[Category: Gene regulation]]
		+	[[Category: Hexasome]]
		+	[[Category: Nucleosome]]
		+	[[Category: Nucleosome breathing]]

OCA: Protected "6esh" [edit=sysop:move=sysop]

OCA — Wed, 01 Nov 2017 05:04:43 GMT

Protected "6esh" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 1 November 2017

OCA: New page: '''Unreleased structure''' The entry 6esh is ON HOLD Authors: Bilokapic, S., Halic, M. Description: Nucleosome breathing : Class 3 Category: Unreleased Structures [[Category: Halic...

OCA — Wed, 01 Nov 2017 05:04:42 GMT

New page: '''Unreleased structure''' The entry 6esh is ON HOLD Authors: Bilokapic, S., Halic, M. Description: Nucleosome breathing : Class 3 Category: Unreleased Structures [[Category: Halic...

New page

'''Unreleased structure'''

The entry 6esh is ON HOLD

Authors: Bilokapic, S., Halic, M.

Description: Nucleosome breathing : Class 3
[[Category: Unreleased Structures]]
[[Category: Halic, M]]
[[Category: Bilokapic, S]]