6ews - Revision history

OCA at 10:44, 14 June 2023

OCA — Wed, 14 Jun 2023 10:44:13 GMT

←Older revision		Revision as of 10:44, 14 June 2023
Line 1:		Line 1:

	==Solution Structure of Rhabdopeptide NRPS Docking Domain Kj12A-NDD==		==Solution Structure of Rhabdopeptide NRPS Docking Domain Kj12A-NDD==
-	<StructureSection load='6ews' size='340' side='right'caption='[[6ews~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6ews' size='340' side='right'caption='[[6ews]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ews]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cip_109067 Cip 109067~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EWS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ews]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenorhabdus_stockiae Xenorhabdus stockiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EWS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ews OCA], [https://pdbe.org/6ews PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ews RCSB], [https://www.ebi.ac.uk/pdbsum/6ews PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ews ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ews OCA], [https://pdbe.org/6ews PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ews RCSB], [https://www.ebi.ac.uk/pdbsum/6ews PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ews ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A173DW33_9GAMM A0A173DW33_9GAMM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cip 109067]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bode~~, H B~~]]	+	[[Category: Xenorhabdus stockiae]]
-	[[Category: Cai, X]]	+	[[Category: Bode HB]]
-	[[Category: Hacker, C]]	+	[[Category: Cai X]]
-	[[Category: Kegler, C]]	+	[[Category: Hacker C]]
-	[[Category: Weickhmann~~, A K~~]]	+	[[Category: Kegler C]]
-	[[Category: Woehnert, J]]	+	[[Category: Weickhmann AK]]
-	[[Category: Zhao, L]]	+	[[Category: Woehnert J]]
-	~~[[Category: Peptide binding protein]]~~	+	[[Category: Zhao L]]
-	~~[[Category: Protein~~]]	+

OCA at 07:40, 25 June 2021

OCA — Fri, 25 Jun 2021 07:40:02 GMT

←Older revision		Revision as of 07:40, 25 June 2021
Line 3:		Line 3:
	<StructureSection load='6ews' size='340' side='right'caption='[[6ews]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6ews' size='340' side='right'caption='[[6ews]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ews]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cip_109067 Cip 109067]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EWS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EWS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ews]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cip_109067 Cip 109067]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EWS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ews OCA], [~~http~~://pdbe.org/6ews PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ews RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ews PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ews ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ews OCA], [https://pdbe.org/6ews PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ews RCSB], [https://www.ebi.ac.uk/pdbsum/6ews PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ews ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:25, 10 May 2019

OCA — Fri, 10 May 2019 13:25:08 GMT

←Older revision		Revision as of 13:25, 10 May 2019
Line 1:		Line 1:

	==Solution Structure of Rhabdopeptide NRPS Docking Domain Kj12A-NDD==		==Solution Structure of Rhabdopeptide NRPS Docking Domain Kj12A-NDD==
-	<StructureSection load='6ews' size='340' side='right' caption='[[6ews]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='6ews' size='340' side='right'caption='[[6ews]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ews]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EWS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ews]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cip_109067 Cip 109067]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EWS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ews OCA], [http://pdbe.org/6ews PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ews RCSB], [http://www.ebi.ac.uk/pdbsum/6ews PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ews ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ews OCA], [http://pdbe.org/6ews PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ews RCSB], [http://www.ebi.ac.uk/pdbsum/6ews PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ews ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cip 109067]]
		+	[[Category: Large Structures]]
	[[Category: Bode, H B]]		[[Category: Bode, H B]]
	[[Category: Cai, X]]		[[Category: Cai, X]]

OCA at 06:55, 31 October 2018

OCA — Wed, 31 Oct 2018 06:55:01 GMT

←Older revision		Revision as of 06:55, 31 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ews is ~~ON HOLD until Paper~~ Publication	+	==Solution Structure of Rhabdopeptide NRPS Docking Domain Kj12A-NDD==
		+	<StructureSection load='6ews' size='340' side='right' caption='[[6ews]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ews]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EWS FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ews OCA], [http://pdbe.org/6ews PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ews RCSB], [http://www.ebi.ac.uk/pdbsum/6ews PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ews ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several peptides in clinical use are derived from non-ribosomal peptide synthetases (NRPS). In these systems multiple NRPS subunits interact with each other in a specific linear order mediated by specific docking domains (DDs), whose structures are not known yet, to synthesize well-defined peptide products. In contrast to classical NRPSs, single-module NRPS subunits responsible for the generation of rhabdopeptide/xenortide-like peptides (RXPs) can act in different order depending on subunit stoichiometry thereby producing peptide libraries. To define the basis for their unusual interaction patterns, we determine the structures of all N-terminal DDs ((N)DDs) as well as of an (N)DD-(C)DD complex and characterize all putative DD interactions thermodynamically for such a system. Key amino acid residues for DD interactions are identified that upon their exchange change the DD affinity and result in predictable changes in peptide production. Recognition rules for DD interactions are identified that also operate in other megasynthase complexes.

-	~~Authors: Hacker~~, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, ~~A.K.~~, Bode, H.B.~~, Woehnert, J~~.	+	Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS.,Hacker C, Cai X, Kegler C, Zhao L, Weickhmann AK, Wurm JP, Bode HB, Wohnert J Nat Commun. 2018 Oct 19;9(1):4366. doi: 10.1038/s41467-018-06712-1. PMID:30341296<ref>PMID:30341296</ref>

-	~~Description: Solution Structure~~ of ~~Rhabdopeptide NRPS Docking Domain Kj12A-NDD~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Zhao, L]]~~	+	<div class="pdbe-citations 6ews" style="background-color:#fffaf0;"></div>
-	~~[[Category: Weickhmann, A.K]]~~	+	== References ==
-	~~[[Category: Kegler, C]]~~	+	<references/>
-	[[Category: ~~Hacker~~, C]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Bode, H B]]
	[[Category: Cai, X]]		[[Category: Cai, X]]
		+	[[Category: Hacker, C]]
		+	[[Category: Kegler, C]]
		+	[[Category: Weickhmann, A K]]
	[[Category: Woehnert, J]]		[[Category: Woehnert, J]]
-	[[Category: ~~Bode~~, ~~H.B~~]]	+	[[Category: Zhao, L]]
		+	[[Category: Peptide binding protein]]
		+	[[Category: Protein]]

OCA at 12:35, 11 April 2018

OCA — Wed, 11 Apr 2018 12:35:04 GMT

←Older revision		Revision as of 12:35, 11 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ews is ON HOLD	+	The entry 6ews is ON HOLD until Paper Publication

	Authors: Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J.		Authors: Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J.

-	Description: Solution Structure of Rhabdopeptide NRPS Docking Domain ~~Kj12CDD~~	+	Description: Solution Structure of Rhabdopeptide NRPS Docking Domain Kj12A-NDD
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Zhao, L]]		[[Category: Zhao, L]]

OCA: Protected "6ews" [edit=sysop:move=sysop]

OCA — Wed, 15 Nov 2017 06:30:11 GMT

Protected "6ews" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:30, 15 November 2017

OCA: New page: '''Unreleased structure''' The entry 6ews is ON HOLD Authors: Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J. Description: Solution Structure of R...

OCA — Wed, 15 Nov 2017 06:30:09 GMT

New page: '''Unreleased structure''' The entry 6ews is ON HOLD Authors: Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J. Description: Solution Structure of R...

New page

'''Unreleased structure'''

The entry 6ews is ON HOLD

Authors: Hacker, C., Cai, X., Kegler, C., Zhao, L., Weickhmann, A.K., Bode, H.B., Woehnert, J.

Description: Solution Structure of Rhabdopeptide NRPS Docking Domain Kj12CDD
[[Category: Unreleased Structures]]
[[Category: Zhao, L]]
[[Category: Weickhmann, A.K]]
[[Category: Kegler, C]]
[[Category: Hacker, C]]
[[Category: Cai, X]]
[[Category: Woehnert, J]]
[[Category: Bode, H.B]]