OCA at 16:20, 15 August 2018

OCA — Wed, 15 Aug 2018 16:20:55 GMT

←Older revision		Revision as of 16:20, 15 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6eyo is ~~ON HOLD until Paper~~ Publication	+	==Structure of extended IgE-Fc in complex with two anti-IgE Fabs==
		+	<StructureSection load='6eyo' size='340' side='right' caption='[[6eyo]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6eyo]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyo OCA], [http://pdbe.org/6eyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eyo RCSB], [http://www.ebi.ac.uk/pdbsum/6eyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyo ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Immunoglobulin E (IgE) antibodies play a central role in the allergic response: interaction with FcepsilonRI on mast cells and basophils leads to immediate hypersensitivity reactions upon allergen challenge, while interaction with CD23/FcepsilonRII, expressed on a variety of cells, regulates IgE synthesis among other activities. The receptor-binding IgE-Fc region has recently been found to display remarkable flexibility, from acutely bent to extended conformations, with allosteric communication between the distant FcepsilonRI and CD23 binding sites. We report the structure of an anti-IgE antibody Fab (8D6) bound to IgE-Fc through a mixed protein-carbohydrate epitope, revealing further flexibility and a novel extended conformation with potential relevance to that of membrane-bound IgE in the B cell receptor for antigen. Unlike the earlier, clinically approved anti-IgE antibody omalizumab, 8D6 inhibits binding to FcepsilonRI but not CD23; the structure reveals how this discrimination is achieved through both orthosteric and allosteric mechanisms, supporting therapeutic strategies that retain the benefits of CD23 binding.

-	~~Authors~~:	+	Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.,Chen JB, Ramadani F, Pang MOY, Beavil RL, Holdom MD, Mitropoulou AN, Beavil AJ, Gould HJ, Chang TW, Sutton BJ, McDonnell JM, Davies AM Sci Rep. 2018 Aug 1;8(1):11548. doi: 10.1038/s41598-018-29664-4. PMID:30069035<ref>PMID:30069035</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6eyo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beavil, A J]]
		+	[[Category: Beavil, R L]]
		+	[[Category: Chang, T W]]
		+	[[Category: Chen, J B]]
		+	[[Category: Davies, A M]]
		+	[[Category: Gould, H J]]
		+	[[Category: Holdom, M D]]
		+	[[Category: McDonnell, J M]]
		+	[[Category: Mitropoulou, A N]]
		+	[[Category: Pang, M O.Y]]
		+	[[Category: Ramadani, F]]
		+	[[Category: Sutton, B J]]
		+	[[Category: Antibody]]
		+	[[Category: Complex]]
		+	[[Category: Fab]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin e]]

OCA at 06:10, 6 December 2017

OCA — Wed, 06 Dec 2017 06:10:17 GMT

←Older revision		Revision as of 06:10, 6 December 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6eyo is ON HOLD	+	The entry 6eyo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6eyo" [edit=sysop:move=sysop]

OCA — Wed, 22 Nov 2017 06:42:53 GMT

Protected "6eyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 22 November 2017

OCA: New page: '''Unreleased structure''' The entry 6eyo is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Nov 2017 06:42:52 GMT

New page: '''Unreleased structure''' The entry 6eyo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6eyo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6eyo - Revision history

OCA at 16:20, 15 August 2018

OCA at 06:10, 6 December 2017

OCA: Protected "6eyo" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6eyo is ON HOLD Authors: Description: Category: Unreleased Structures