6eyu - Revision history

OCA at 07:17, 31 January 2018

OCA — Wed, 31 Jan 2018 07:17:36 GMT

←Older revision		Revision as of 07:17, 31 January 2018
Line 3:		Line 3:
	<StructureSection load='6eyu' size='340' side='right' caption='[[6eyu]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6eyu' size='340' side='right' caption='[[6eyu]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eyu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eyu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Candidatus_nanosalina_sp._j07ab43 Candidatus nanosalina sp. j07ab43]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MUN:[(2~{S})-2,3-bis(oxidanyl)propyl]+(~{E})-undec-2-enoate'>MUN</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MUN:[(2~{S})-2,3-bis(oxidanyl)propyl]+(~{E})-undec-2-enoate'>MUN</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">J07AB43_12860 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=889948 Candidatus Nanosalina sp. J07AB43])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyu OCA], [http://pdbe.org/6eyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eyu RCSB], [http://www.ebi.ac.uk/pdbsum/6eyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyu OCA], [http://pdbe.org/6eyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eyu RCSB], [http://www.ebi.ac.uk/pdbsum/6eyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyu ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Candidatus nanosalina sp. j07ab43]]
	[[Category: Alekseev, A]]		[[Category: Alekseev, A]]
	[[Category: Borshchevskiy, V]]		[[Category: Borshchevskiy, V]]

OCA at 07:06, 13 December 2017

OCA — Wed, 13 Dec 2017 07:06:34 GMT

←Older revision		Revision as of 07:06, 13 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6eyu is ~~ON HOLD~~	+	==Crystal structure of the inward H(+) pump xenorhodopsin==
		+	<StructureSection load='6eyu' size='340' side='right' caption='[[6eyu]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6eyu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MUN:[(2~{S})-2,3-bis(oxidanyl)propyl]+(~{E})-undec-2-enoate'>MUN</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyu OCA], [http://pdbe.org/6eyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eyu RCSB], [http://www.ebi.ac.uk/pdbsum/6eyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyu ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Generation of an electrochemical proton gradient is the first step of cell bioenergetics. In prokaryotes, the gradient is created by outward membrane protein proton pumps. Inward plasma membrane native proton pumps are yet unknown. We describe comprehensive functional studies of the representatives of the yet noncharacterized xenorhodopsins from Nanohaloarchaea family of microbial rhodopsins. They are inward proton pumps as we demonstrate in model membrane systems, Escherichia coli cells, human embryonic kidney cells, neuroblastoma cells, and rat hippocampal neuronal cells. We also solved the structure of a xenorhodopsin from the nanohalosarchaeon Nanosalina (NsXeR) and suggest a mechanism of inward proton pumping. We demonstrate that the NsXeR is a powerful pump, which is able to elicit action potentials in rat hippocampal neuronal cells up to their maximal intrinsic firing frequency. Hence, inwardly directed proton pumps are suitable for light-induced remote control of neurons, and they are an alternative to the well-known cation-selective channelrhodopsins.

-	~~Authors~~: ~~Kovalev, K~~., Shevchenko, V., ~~Polovinkin~~, V., ~~Mager~~, ~~T., Gushchin~~, I., ~~Melnikov~~, I., Borshchevskiy, V~~., Popov~~, A., ~~Alekseev~~, A., ~~Gordeliy~~, V.	+	Inward H(+) pump xenorhodopsin: Mechanism and alternative optogenetic approach.,Shevchenko V, Mager T, Kovalev K, Polovinkin V, Alekseev A, Juettner J, Chizhov I, Bamann C, Vavourakis C, Ghai R, Gushchin I, Borshchevskiy V, Rogachev A, Melnikov I, Popov A, Balandin T, Rodriguez-Valera F, Manstein DJ, Bueldt G, Bamberg E, Gordeliy V Sci Adv. 2017 Sep 22;3(9):e1603187. doi: 10.1126/sciadv.1603187. eCollection 2017, Sep. PMID:28948217<ref>PMID:28948217</ref>

-	~~Description: Crystal structure~~ of the ~~inward H(+) pump xenorhodopsin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Popov~~, A]]	+	<div class="pdbe-citations 6eyu" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Melnikov~~, I]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alekseev, A]]
		+	[[Category: Borshchevskiy, V]]
		+	[[Category: Gordeliy, V]]
	[[Category: Gushchin, I]]		[[Category: Gushchin, I]]
		+	[[Category: Kovalev, K]]
	[[Category: Mager, T]]		[[Category: Mager, T]]
		+	[[Category: Melnikov, I]]
	[[Category: Polovinkin, V]]		[[Category: Polovinkin, V]]
-	[[Category: ~~Gordeliy~~, ~~V]]~~	+	[[Category: Popov, A]]
-	~~[[Category: Kovalev, K]]~~	+
-	~~[[Category: Borshchevskiy, V~~]]	+
	[[Category: Shevchenko, V]]		[[Category: Shevchenko, V]]
-	[[Category: ~~Alekseev, A~~]]	+	[[Category: Membrane protein]]
		+	[[Category: Proton transport]]
		+	[[Category: Retinal protein]]

OCA: Protected "6eyu" [edit=sysop:move=sysop]

OCA — Wed, 22 Nov 2017 06:43:10 GMT

Protected "6eyu" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 22 November 2017

OCA: New page: '''Unreleased structure''' The entry 6eyu is ON HOLD Authors: Kovalev, K., Shevchenko, V., Polovinkin, V., Mager, T., Gushchin, I., Melnikov, I., Borshchevskiy, V., Popov, A., Alekseev,...

OCA — Wed, 22 Nov 2017 06:43:09 GMT

New page: '''Unreleased structure''' The entry 6eyu is ON HOLD Authors: Kovalev, K., Shevchenko, V., Polovinkin, V., Mager, T., Gushchin, I., Melnikov, I., Borshchevskiy, V., Popov, A., Alekseev,...

New page

'''Unreleased structure'''

The entry 6eyu is ON HOLD

Authors: Kovalev, K., Shevchenko, V., Polovinkin, V., Mager, T., Gushchin, I., Melnikov, I., Borshchevskiy, V., Popov, A., Alekseev, A., Gordeliy, V.

Description: Crystal structure of the inward H(+) pump xenorhodopsin
[[Category: Unreleased Structures]]
[[Category: Popov, A]]
[[Category: Melnikov, I]]
[[Category: Gushchin, I]]
[[Category: Mager, T]]
[[Category: Polovinkin, V]]
[[Category: Gordeliy, V]]
[[Category: Kovalev, K]]
[[Category: Borshchevskiy, V]]
[[Category: Shevchenko, V]]
[[Category: Alekseev, A]]