6eyy - Revision history

OCA at 12:22, 9 May 2024

OCA — Thu, 09 May 2024 12:22:57 GMT

←Older revision		Revision as of 12:22, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='6eyy' size='340' side='right'caption='[[6eyy]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6eyy' size='340' side='right'caption='[[6eyy]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eyy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Streptococcus_phage_73 Streptococcus phage 73]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eyy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_phage_73 Streptococcus phage 73]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EYY FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~6eyx~~\|~~6eyx~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6eyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyy OCA], [~~http~~://pdbe.org/6eyy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6eyy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6eyy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyy OCA], [https://pdbe.org/6eyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eyy RCSB], [https://www.ebi.ac.uk/pdbsum/6eyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1S5PRR0_9CAUD A0A1S5PRR0_9CAUD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Streptococcus phage 73]]		[[Category: Streptococcus phage 73]]
-	[[Category: Amigues, B]]	+	[[Category: Amigues B]]
-	[[Category: Cambillau, C]]	+	[[Category: Cambillau C]]
-	[[Category: Moineau, S]]	+	[[Category: Moineau S]]
-	~~[[Category: Anti-crispr]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Hth fold]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 17:17, 14 August 2019

OCA — Wed, 14 Aug 2019 17:17:28 GMT

←Older revision		Revision as of 17:17, 14 August 2019
Line 1:		Line 1:

	==Anti-CRISPR AcrIIa6 cubic form==		==Anti-CRISPR AcrIIa6 cubic form==
-	<StructureSection load='6eyy' size='340' side='right' caption='[[6eyy]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='6eyy' size='340' side='right'caption='[[6eyy]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6eyy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_phage_73 Streptococcus phage 73]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYY FirstGlance]. <br>		<table><tr><td colspan='2'>[[6eyy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_phage_73 Streptococcus phage 73]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYY FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Streptococcus phage 73]]		[[Category: Streptococcus phage 73]]
	[[Category: Amigues, B]]		[[Category: Amigues, B]]

OCA at 22:12, 9 August 2018

OCA — Thu, 09 Aug 2018 22:12:39 GMT

←Older revision		Revision as of 22:12, 9 August 2018
Line 3:		Line 3:
	<StructureSection load='6eyy' size='340' side='right' caption='[[6eyy]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6eyy' size='340' side='right' caption='[[6eyy]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eyy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eyy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_phage_73 Streptococcus phage 73]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6eyx\|6eyx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6eyx\|6eyx]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyy OCA], [http://pdbe.org/6eyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eyy RCSB], [http://www.ebi.ac.uk/pdbsum/6eyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyy OCA], [http://pdbe.org/6eyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eyy RCSB], [http://www.ebi.ac.uk/pdbsum/6eyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyy ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CRISPR-Cas systems are bacterial anti-viral systems, and bacterial viruses (bacteriophages, phages) can carry anti-CRISPR (Acr) proteins to evade that immunity. Acrs can also fine-tune the activity of CRISPR-based genome-editing tools. While Acrs are prevalent in phages capable of lying dormant in a CRISPR-carrying host, their orthologs have been observed only infrequently in virulent phages. Here we identify AcrIIA6, an Acr encoded in 33% of virulent Streptococcus thermophilus phage genomes. The X-ray structure of AcrIIA6 displays some features unique to this Acr family. We compare the activity of AcrIIA6 to those of other Acrs, including AcrIIA5 (also from S. thermophilus phages), and characterize their effectiveness against a range of CRISPR-Cas systems. Finally, we demonstrate that both Acr families from S. thermophilus phages inhibit Cas9-mediated genome editing of human cells.
		+
		+	Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins.,Hynes AP, Rousseau GM, Agudelo D, Goulet A, Amigues B, Loehr J, Romero DA, Fremaux C, Horvath P, Doyon Y, Cambillau C, Moineau S Nat Commun. 2018 Jul 25;9(1):2919. doi: 10.1038/s41467-018-05092-w. PMID:30046034<ref>PMID:30046034</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6eyy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Streptococcus phage 73]]
	[[Category: Amigues, B]]		[[Category: Amigues, B]]
	[[Category: Cambillau, C]]		[[Category: Cambillau, C]]

OCA at 05:59, 6 June 2018

OCA — Wed, 06 Jun 2018 05:59:50 GMT

←Older revision		Revision as of 05:59, 6 June 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6eyy is ~~ON HOLD until Paper Publication~~	+	==Anti-CRISPR AcrIIa6 cubic form==
-		+	<StructureSection load='6eyy' size='340' side='right' caption='[[6eyy]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6eyy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EYY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6eyx\|6eyx]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eyy OCA], [http://pdbe.org/6eyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eyy RCSB], [http://www.ebi.ac.uk/pdbsum/6eyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eyy ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Amigues, B]]
		+	[[Category: Cambillau, C]]
		+	[[Category: Moineau, S]]
		+	[[Category: Anti-crispr]]
		+	[[Category: Dna binding]]
		+	[[Category: Hth fold]]
		+	[[Category: Viral protein]]

OCA at 05:11, 29 November 2017

OCA — Wed, 29 Nov 2017 05:11:59 GMT

←Older revision		Revision as of 05:11, 29 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6eyy is ON HOLD	+	The entry 6eyy is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6eyy" [edit=sysop:move=sysop]

OCA — Wed, 22 Nov 2017 06:43:31 GMT

Protected "6eyy" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 22 November 2017

OCA: New page: '''Unreleased structure''' The entry 6eyy is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Nov 2017 06:43:30 GMT

New page: '''Unreleased structure''' The entry 6eyy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6eyy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]