OCA at 08:19, 30 January 2019

OCA — Wed, 30 Jan 2019 08:19:45 GMT

←Older revision		Revision as of 08:19, 30 January 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6fbu is ON HOLD until Dec 19 2019~~	+	==Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli (E2Q) in complex with AP-site containing DNA substrate==
-		+	<StructureSection load='6fbu' size='340' side='right' caption='[[6fbu]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors: Pomyalov, S., Lansky, S., Golan, G., Zharkov, D.O., Grollman, A.P., Shoham, G.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fbu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FBU FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli (E2Q) in complex with AP-site containing DNA substrate	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PED:PENTANE-3,4-DIOL-5-PHOSPHATE'>PED</scene></td></tr>
-	[[~~Category~~: ~~Shoham~~, G]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ea0\|2ea0]], [[2opf\|2opf]], [[2oq4\|2oq4]]</td></tr>
-	[[~~Category~~: ~~Grollman~~, ~~A.P~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fbu OCA], [http://pdbe.org/6fbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fbu RCSB], [http://www.ebi.ac.uk/pdbsum/6fbu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fbu ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Pomyalov~~, S]]	+	</table>
-	[[~~Category~~: ~~Zharkov, D~~.O]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/END8_ECOLI END8_ECOLI]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.<ref>PMID:20031487</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Golan, G]]		[[Category: Golan, G]]
		+	[[Category: Grollman, A P]]
	[[Category: Lansky, S]]		[[Category: Lansky, S]]
		+	[[Category: Pomyalov, S]]
		+	[[Category: Shoham, G]]
		+	[[Category: Zharkov, D O]]
		+	[[Category: Covalent intermediate]]
		+	[[Category: Dna repair enzyme]]
		+	[[Category: Endonuclease-viii]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nei]]

OCA: Protected "6fbu" [edit=sysop:move=sysop]

OCA — Wed, 27 Dec 2017 07:32:31 GMT

Protected "6fbu" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:32, 27 December 2017

OCA: New page: '''Unreleased structure''' The entry 6fbu is ON HOLD until Dec 19 2019 Authors: Pomyalov, S., Lansky, S., Golan, G., Zharkov, D.O., Grollman, A.P., Shoham, G. Description: Crystal stru...

OCA — Wed, 27 Dec 2017 07:32:30 GMT

New page: '''Unreleased structure''' The entry 6fbu is ON HOLD until Dec 19 2019 Authors: Pomyalov, S., Lansky, S., Golan, G., Zharkov, D.O., Grollman, A.P., Shoham, G. Description: Crystal stru...

New page

'''Unreleased structure'''

The entry 6fbu is ON HOLD until Dec 19 2019

Authors: Pomyalov, S., Lansky, S., Golan, G., Zharkov, D.O., Grollman, A.P., Shoham, G.

Description: Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli (E2Q) in complex with AP-site containing DNA substrate
[[Category: Unreleased Structures]]
[[Category: Shoham, G]]
[[Category: Grollman, A.P]]
[[Category: Pomyalov, S]]
[[Category: Zharkov, D.O]]
[[Category: Golan, G]]
[[Category: Lansky, S]]

6fbu - Revision history

OCA at 08:19, 30 January 2019

OCA: Protected "6fbu" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6fbu is ON HOLD until Dec 19 2019 Authors: Pomyalov, S., Lansky, S., Golan, G., Zharkov, D.O., Grollman, A.P., Shoham, G. Description: Crystal stru...