6fc0 - Revision history

OCA at 22:13, 9 August 2018

OCA — Thu, 09 Aug 2018 22:13:21 GMT

←Older revision		Revision as of 22:13, 9 August 2018
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	<StructureSection load='6fc0' size='340' side='right' caption='[[6fc0]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='6fc0' size='340' side='right' caption='[[6fc0]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fc0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc0 OCA], [http://pdbe.org/6fc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc0 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0058450 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), CTHT_0071550 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc0 OCA], [http://pdbe.org/6fc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The interaction of the eukaryotic initiation factor 4G (eIF4G) with the cap-binding protein eIF4E initiates cap-dependent translation and is regulated by the 4E-binding proteins (4E-BPs), which compete with eIF4G to repress translation. Metazoan eIF4G and 4E-BPs interact with eIF4E via canonical and non-canonical motifs that bind to the dorsal and lateral surface of eIF4E in a bipartite recognition mode. However, previous studies pointed to mechanistic differences in how fungi and metazoans regulate protein synthesis. We present crystal structures of the yeast eIF4E bound to two yeast 4E-BPs, p20 and Eap1p, as well as crystal structures of a fungal eIF4E-eIF4G complex. We demonstrate that the core principles of molecular recognition of eIF4E are in fact highly conserved among translational activators and repressors in eukaryotes. Finally, we reveal that highly specialized structural motifs do exist and serve to modulate the affinity of protein-protein interactions that regulate cap-dependent translation initiation in fungi.
		+
		+	Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.,Gruner S, Weber R, Peter D, Chung MY, Igreja C, Valkov E, Izaurralde E Nucleic Acids Res. 2018 Jul 27;46(13):6893-6908. doi: 10.1093/nar/gky542. PMID:30053226<ref>PMID:30053226</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6fc0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chatd]]
	[[Category: Gruener, S]]		[[Category: Gruener, S]]
	[[Category: Valkov, E]]		[[Category: Valkov, E]]
	[[Category: Translation]]		[[Category: Translation]]
	[[Category: Translation translational control translation initiation gene expression]]		[[Category: Translation translational control translation initiation gene expression]]

OCA at 05:39, 27 June 2018

OCA — Wed, 27 Jun 2018 05:39:52 GMT

←Older revision		Revision as of 05:39, 27 June 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6fc0 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the eIF4E-eIF4G complex from Chaetomium thermophilum==
-		+	<StructureSection load='6fc0' size='340' side='right' caption='[[6fc0]], [[Resolution\|resolution]] 1.29Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fc0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC0 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc0 OCA], [http://pdbe.org/6fc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc0 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gruener, S]]
		+	[[Category: Valkov, E]]
		+	[[Category: Translation]]
		+	[[Category: Translation translational control translation initiation gene expression]]

OCA at 05:50, 17 January 2018

OCA — Wed, 17 Jan 2018 05:50:34 GMT

←Older revision		Revision as of 05:50, 17 January 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6fc0 is ON HOLD	+	The entry 6fc0 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6fc0" [edit=sysop:move=sysop]

OCA — Wed, 27 Dec 2017 07:33:03 GMT

Protected "6fc0" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:33, 27 December 2017

OCA: New page: '''Unreleased structure''' The entry 6fc0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Dec 2017 07:33:02 GMT

New page: '''Unreleased structure''' The entry 6fc0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fc0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]