6fgg - Revision history

OCA at 08:00, 29 August 2018

OCA — Wed, 29 Aug 2018 08:00:31 GMT

←Older revision		Revision as of 08:00, 29 August 2018
Line 3:		Line 3:
	<StructureSection load='6fgg' size='340' side='right' caption='[[6fgg]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='6fgg' size='340' side='right' caption='[[6fgg]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fgg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FGG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FGG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9B:~{N}-[3-[2-(dimethylamino)ethyl]-2-oxidanylidene-1,3-benzoxazol-5-yl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide'>D9B</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9B:~{N}-[3-[2-(dimethylamino)ethyl]-2-oxidanylidene-1,3-benzoxazol-5-yl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide'>D9B</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6fg6\|6fg6]], [[6fgf\|6fgf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6fg6\|6fg6]], [[6fgf\|6fgf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BAZ2A, KIAA0314, TIP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fgg OCA], [http://pdbe.org/6fgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fgg RCSB], [http://www.ebi.ac.uk/pdbsum/6fgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fgg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fgg OCA], [http://pdbe.org/6fgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fgg RCSB], [http://www.ebi.ac.uk/pdbsum/6fgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fgg ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Caflisch, A]]		[[Category: Caflisch, A]]
	[[Category: Lolli, G]]		[[Category: Lolli, G]]

OCA at 05:38, 30 May 2018

OCA — Wed, 30 May 2018 05:38:11 GMT

←Older revision		Revision as of 05:38, 30 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6fgg is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridinone compound 5==
		+	<StructureSection load='6fgg' size='340' side='right' caption='[[6fgg]], [[Resolution\|resolution]] 1.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fgg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FGG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9B:~{N}-[3-[2-(dimethylamino)ethyl]-2-oxidanylidene-1,3-benzoxazol-5-yl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide'>D9B</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6fg6\|6fg6]], [[6fgf\|6fgf]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fgg OCA], [http://pdbe.org/6fgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fgg RCSB], [http://www.ebi.ac.uk/pdbsum/6fgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fgg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bromodomain-containing protein BAZ2A is a validated target in prostate cancer, while the function of its paralog BAZ2B is still undefined. The bromodomains of BAZ2A and BAZ2B have a very similar binding site for their natural ligand, the acetylated lysine side chain. Here, we present an analysis of the binding modes of eight compounds belonging to three distinct chemical classes. For all compounds, the moiety mimicking the natural ligand makes essentially identical interactions in the BAZ2A and BAZ2B bromodomains. In contrast, the rest of the molecule is partially solvent exposed and shows different orientations and interactions in the two bromodomains. Some of these differences could be exploited for designing selective inhibitors within the BAZ2 bromodomain subfamily.

-	~~Authors:~~ Dalle Vedove, A., Spiliotopoulos, D., ~~Lolli~~, G., Caflisch, A.	+	Structural Analysis of Small Molecule Binding to the BAZ2A and BAZ2B Bromodomains.,Dalle Vedove A, Spiliotopoulos D, D'Agostino VG, Marchand JR, Unzue A, Nevado C, Lolli G, Caflisch A ChemMedChem. 2018 May 17. doi: 10.1002/cmdc.201800234. PMID:29770599<ref>PMID:29770599</ref>

-	~~Description: Crystal Structure~~ of ~~BAZ2A bromodomain in complex with 1-methylpyridinone compound 5~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Dalle Vedove~~, A]]	+	<div class="pdbe-citations 6fgg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Caflisch, A]]
	[[Category: Lolli, G]]		[[Category: Lolli, G]]
	[[Category: Spiliotopoulos, D]]		[[Category: Spiliotopoulos, D]]
-	[[Category: ~~Caflisch~~, A]]	+	[[Category: Vedove, A Dalle]]
		+	[[Category: Four helical bundle]]
		+	[[Category: Transcription]]

OCA: Protected "6fgg" [edit=sysop:move=sysop]

OCA — Wed, 17 Jan 2018 05:54:17 GMT

Protected "6fgg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:54, 17 January 2018

OCA: New page: '''Unreleased structure''' The entry 6fgg is ON HOLD until Paper Publication Authors: Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. Description: Crystal Structure of BA...

OCA — Wed, 17 Jan 2018 05:54:16 GMT

New page: '''Unreleased structure''' The entry 6fgg is ON HOLD until Paper Publication Authors: Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A. Description: Crystal Structure of BA...

New page

'''Unreleased structure'''

The entry 6fgg is ON HOLD until Paper Publication

Authors: Dalle Vedove, A., Spiliotopoulos, D., Lolli, G., Caflisch, A.

Description: Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridinone compound 5
[[Category: Unreleased Structures]]
[[Category: Dalle Vedove, A]]
[[Category: Lolli, G]]
[[Category: Spiliotopoulos, D]]
[[Category: Caflisch, A]]