6fi7 - Revision history

OCA at 10:46, 14 June 2023

OCA — Wed, 14 Jun 2023 10:46:08 GMT

←Older revision		Revision as of 10:46, 14 June 2023
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	==E.coli Sigma factor S (RpoS) Region 4==		==E.coli Sigma factor S (RpoS) Region 4==
-	<StructureSection load='6fi7' size='340' side='right' caption='[[6fi7~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='6fi7' size='340' side='right'caption='[[6fi7]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fi7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FI7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FI7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fi7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FI7 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpoS, appR, katF, nur, otsX, sigS, b2741, JW5437 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fi7 OCA], [https://pdbe.org/6fi7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fi7 RCSB], [https://www.ebi.ac.uk/pdbsum/6fi7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fi7 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fi7 OCA], [~~http~~://pdbe.org/6fi7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fi7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fi7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fi7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RPOS_ECOLI RPOS_ECOLI]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.[HAMAP-Rule:MF_00959]<ref>PMID:15558318</ref> <ref>PMID:15716429</ref> <ref>PMID:16511888</ref> <ref>PMID:21398637</ref> <ref>PMID:8475100</ref> Protects stationary phase cells from killing induced by endoribonuclease MazF.<ref>PMID:19251848</ref>	+	[https://www.uniprot.org/uniprot/RPOS_ECOLI RPOS_ECOLI] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.[HAMAP-Rule:MF_00959]<ref>PMID:15558318</ref> <ref>PMID:15716429</ref> <ref>PMID:16511888</ref> <ref>PMID:21398637</ref> <ref>PMID:8475100</ref> Protects stationary phase cells from killing induced by endoribonuclease MazF.<ref>PMID:19251848</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 6fi7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6fi7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sigma factor 3D structures\|Sigma factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Liu, B~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Matthews, S J~~]]	+	[[Category: Liu B]]
-	[[Category: ~~Apo-rpos region 4]]~~	+	[[Category: Matthews SJ]]
-	~~[[Category: Free rpos region4]]~~	+
-	~~[[Category: Rna binding protein~~]]	+

OCA at 08:14, 14 June 2018

OCA — Thu, 14 Jun 2018 08:14:50 GMT

←Older revision		Revision as of 08:14, 14 June 2018
Line 3:		Line 3:
	<StructureSection load='6fi7' size='340' side='right' caption='[[6fi7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='6fi7' size='340' side='right' caption='[[6fi7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fi7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FI7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fi7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FI7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fi7 OCA], [http://pdbe.org/6fi7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fi7 RCSB], [http://www.ebi.ac.uk/pdbsum/6fi7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fi7 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rpoS, appR, katF, nur, otsX, sigS, b2741, JW5437 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fi7 OCA], [http://pdbe.org/6fi7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fi7 RCSB], [http://www.ebi.ac.uk/pdbsum/6fi7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fi7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Liu, B]]		[[Category: Liu, B]]
	[[Category: Matthews, S J]]		[[Category: Matthews, S J]]

OCA at 06:01, 6 June 2018

OCA — Wed, 06 Jun 2018 06:01:11 GMT

←Older revision		Revision as of 06:01, 6 June 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6fi7 is ~~ON HOLD~~	+	==E.coli Sigma factor S (RpoS) Region 4==
		+	<StructureSection load='6fi7' size='340' side='right' caption='[[6fi7]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fi7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FI7 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fi7 OCA], [http://pdbe.org/6fi7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fi7 RCSB], [http://www.ebi.ac.uk/pdbsum/6fi7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fi7 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RPOS_ECOLI RPOS_ECOLI]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.[HAMAP-Rule:MF_00959]<ref>PMID:15558318</ref> <ref>PMID:15716429</ref> <ref>PMID:16511888</ref> <ref>PMID:21398637</ref> <ref>PMID:8475100</ref> Protects stationary phase cells from killing induced by endoribonuclease MazF.<ref>PMID:19251848</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	T7 development in Escherichia coli requires the inhibition of the housekeeping form of the bacterial RNA polymerase (RNAP), Esigma(70), by two T7 proteins: Gp2 and Gp5.7. Although the biological role of Gp2 is well understood, that of Gp5.7 remains to be fully deciphered. Here, we present results from functional and structural analyses to reveal that Gp5.7 primarily serves to inhibit Esigma(S), the predominant form of the RNAP in the stationary phase of growth, which accumulates in exponentially growing E. coli as a consequence of the buildup of guanosine pentaphosphate [(p)ppGpp] during T7 development. We further demonstrate a requirement of Gp5.7 for T7 development in E. coli cells in the stationary phase of growth. Our finding represents a paradigm for how some lytic phages have evolved distinct mechanisms to inhibit the bacterial transcription machinery to facilitate phage development in bacteria in the exponential and stationary phases of growth.

-	~~Authors: Liu~~, B., Matthews, S.J.	+	T7 phage factor required for managing RpoS in Escherichia coli.,Tabib-Salazar A, Liu B, Barker D, Burchell L, Qimron U, Matthews SJ, Wigneshweraraj S Proc Natl Acad Sci U S A. 2018 May 22. pii: 1800429115. doi:, 10.1073/pnas.1800429115. PMID:29789383<ref>PMID:29789383</ref>

-	~~Description: E~~.~~coli Sigma factor~~ S ~~(RpoS) Region 4~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Matthews, S.J]]~~	+	<div class="pdbe-citations 6fi7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Liu, B]]		[[Category: Liu, B]]
		+	[[Category: Matthews, S J]]
		+	[[Category: Apo-rpos region 4]]
		+	[[Category: Free rpos region4]]
		+	[[Category: Rna binding protein]]

OCA: Protected "6fi7" [edit=sysop:move=sysop]

OCA — Wed, 24 Jan 2018 17:28:56 GMT

Protected "6fi7" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:28, 24 January 2018

OCA: New page: '''Unreleased structure''' The entry 6fi7 is ON HOLD Authors: Liu, B., Matthews, S.J. Description: E.coli Sigma factor S (RpoS) Region 4 Category: Unreleased Structures [[Category:...

OCA — Wed, 24 Jan 2018 17:28:55 GMT

New page: '''Unreleased structure''' The entry 6fi7 is ON HOLD Authors: Liu, B., Matthews, S.J. Description: E.coli Sigma factor S (RpoS) Region 4 Category: Unreleased Structures [[Category:...

New page

'''Unreleased structure'''

The entry 6fi7 is ON HOLD

Authors: Liu, B., Matthews, S.J.

Description: E.coli Sigma factor S (RpoS) Region 4
[[Category: Unreleased Structures]]
[[Category: Matthews, S.J]]
[[Category: Liu, B]]