6fkk - Revision history

OCA at 10:22, 18 March 2021

OCA — Thu, 18 Mar 2021 10:22:22 GMT

←Older revision		Revision as of 10:22, 18 March 2021
Line 3:		Line 3:
	<StructureSection load='6fkk' size='340' side='right'caption='[[6fkk]], [[Resolution\|resolution]] 2.78Å' scene=''>		<StructureSection load='6fkk' size='340' side='right'caption='[[6fkk]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fkk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FKK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FKK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sema1b, Sema-1b, Sema-1b-RB, semaphorin-like, CG6446, Dmel_CG6446 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sema1b, Sema-1b, Sema-1b-RB, semaphorin-like, CG6446, Dmel_CG6446 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fkk OCA], [~~http~~://pdbe.org/6fkk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fkk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fkk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fkk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fkk OCA], [https://pdbe.org/6fkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fkk RCSB], [https://www.ebi.ac.uk/pdbsum/6fkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fkk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 6fkk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6fkk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Semaphorin\|Semaphorin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:53, 28 August 2019

OCA — Wed, 28 Aug 2019 15:53:45 GMT

←Older revision		Revision as of 15:53, 28 August 2019
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fkk OCA], [http://pdbe.org/6fkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fkk RCSB], [http://www.ebi.ac.uk/pdbsum/6fkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fkk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fkk OCA], [http://pdbe.org/6fkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fkk RCSB], [http://www.ebi.ac.uk/pdbsum/6fkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fkk ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Semaphorin ligands and their plexin receptors are one of the major cell guidance factors that trigger localised changes in the cytoskeleton. Binding of semaphorin homodimer to plexin brings two plexins in close proximity which is a prerequisite for plexin signalling. This model appears to be too simplistic to explain the complexity and functional versatility of these molecules. Here, we determine crystal structures for all members of Drosophila class 1 and 2 semaphorins. Unlike previously reported semaphorin structures, Sema1a, Sema2a and Sema2b show stabilisation of sema domain dimer formation via a disulfide bond. Unexpectedly, our structural and biophysical data show Sema1b is a monomer suggesting that semaphorin function may not be restricted to dimers. We demonstrate that semaphorins can form heterodimers with members of the same semaphorin class. This heterodimerization provides a potential mechanism for cross-talk between different plexins and co-receptors to allow fine-tuning of cell signalling.
		+
		+	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.,Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY Nat Commun. 2019 Aug 15;10(1):3691. doi: 10.1038/s41467-019-11683-y. PMID:31417095<ref>PMID:31417095</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6fkk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:28, 21 August 2019

OCA — Wed, 21 Aug 2019 06:28:13 GMT

←Older revision		Revision as of 06:28, 21 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6fkk is ~~ON HOLD until Paper Publication~~	+	==Drosophila Semaphorin 1b, extracellular domains 1-2==
-		+	<StructureSection load='6fkk' size='340' side='right'caption='[[6fkk]], [[Resolution\|resolution]] 2.78Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FKK FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sema1b, Sema-1b, Sema-1b-RB, semaphorin-like, CG6446, Dmel_CG6446 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fkk OCA], [http://pdbe.org/6fkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fkk RCSB], [http://www.ebi.ac.uk/pdbsum/6fkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fkk ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Drome]]
		+	[[Category: Large Structures]]
		+	[[Category: Harlos, K]]
		+	[[Category: Jones, E Y]]
		+	[[Category: Rozbesky, D]]
		+	[[Category: Axon guidance cue]]
		+	[[Category: Cell cell signaling]]
		+	[[Category: Sema domain]]
		+	[[Category: Semaphorin]]
		+	[[Category: Signaling protein]]

OCA at 05:16, 7 February 2018

OCA — Wed, 07 Feb 2018 05:16:24 GMT

←Older revision		Revision as of 05:16, 7 February 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6fkk is ON HOLD	+	The entry 6fkk is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6fkk" [edit=sysop:move=sysop]

OCA — Wed, 31 Jan 2018 04:58:03 GMT

Protected "6fkk" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 31 January 2018

OCA: New page: '''Unreleased structure''' The entry 6fkk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 31 Jan 2018 04:58:02 GMT

New page: '''Unreleased structure''' The entry 6fkk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fkk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]