6fm7 - Revision history

OCA at 05:58, 27 June 2018

OCA — Wed, 27 Jun 2018 05:58:36 GMT

←Older revision		Revision as of 05:58, 27 June 2018
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	<StructureSection load='6fm7' size='340' side='right' caption='[[6fm7]], [[Resolution\|resolution]] 1.04Å' scene=''>		<StructureSection load='6fm7' size='340' side='right' caption='[[6fm7]], [[Resolution\|resolution]] 1.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fm7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FM7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeren Aeren]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FM7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6fm6\|6fm6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6fm6\|6fm6]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29489 AEREN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fm7 OCA], [http://pdbe.org/6fm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fm7 RCSB], [http://www.ebi.ac.uk/pdbsum/6fm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fm7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fm7 OCA], [http://pdbe.org/6fm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fm7 RCSB], [http://www.ebi.ac.uk/pdbsum/6fm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fm7 ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aeren]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Benvenuti, M]]		[[Category: Benvenuti, M]]

OCA at 05:39, 30 May 2018

OCA — Wed, 30 May 2018 05:39:25 GMT

←Older revision		Revision as of 05:39, 30 May 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6fm7 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the class C beta-lactamase TRU-1 from Aeromonas enteropelogenes in complex with avibactam==
		+	<StructureSection load='6fm7' size='340' side='right' caption='[[6fm7]], [[Resolution\|resolution]] 1.04Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fm7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FM7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6fm6\|6fm6]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fm7 OCA], [http://pdbe.org/6fm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fm7 RCSB], [http://www.ebi.ac.uk/pdbsum/6fm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fm7 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	beta-lactamases (BLs) are important antibiotic resistance determinants that significantly compromise the efficacy of valuable beta-lactam antibacterial drugs. For that reason, combinations with beta-lactamase inhibitor were developed. Avibactam is the first non-beta-lactam BL inhibitor introduced in clinical practice. Ceftazidime-avibactam represents one of the few last-resort antibiotics available for the treatment of infections caused by near pandrug-resistant bacteria. TRU-1 is a chromosomally-encoded AmpC-type BL of Aeromonas enteropelogenes, related to the FOX-type BLs and constitutes a good model for class C BLs. TRU-1 crystals provided ultra-high resolution diffraction data for the native enzyme and for its complex with avibactam. The comparison of the native and avibactam-bound structures revealed new details in the conformations of residues relevant for substrate and/or inhibitor binding. Furthermore, the comparison of the TRU-1 and P. aeruginosa AmpC avibactam-bound structures revealed two inhibitor conformations likely corresponding to two different states occurring during inhibitor carbamylation/recyclization.

-	~~Authors: Pozzi,~~ C., De Luca, F., Benvenuti, M~~., Di Pisa, F.~~, Docquier~~, J~~.D.~~, Mangani, S~~.	+	The Atomic Resolution Structure of a Class C beta-lactamase and of its Complex with Avibactam.,Mangani S, Pozzi C, Di Pisa F, De Luca F, Benvenuti M, Docquier JD ChemMedChem. 2018 May 22. doi: 10.1002/cmdc.201800213. PMID:29786960<ref>PMID:29786960</ref>

-	~~Description: Crystal structure~~ of the class ~~C beta~~-~~lactamase TRU~~-~~1 from Aeromonas enteropelogenes in complex with avibactam~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6fm7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
	[[Category: Benvenuti, M]]		[[Category: Benvenuti, M]]
-	[[Category: De Luca, F]]	+	[[Category: Docquier, J D]]
		+	[[Category: Luca, F De]]
	[[Category: Mangani, S]]		[[Category: Mangani, S]]
-	[[Category: ~~Docquier, J.D]]~~	+	[[Category: Pisa, F Di]]
-	~~[[Category: Di~~ Pisa, F]]	+
	[[Category: Pozzi, C]]		[[Category: Pozzi, C]]
		+	[[Category: Aeromonas enteropelogene]]
		+	[[Category: Avibactam]]
		+	[[Category: Class c]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nxl]]
		+	[[Category: Serine beta-lactamase]]
		+	[[Category: Tru-1]]

OCA: Protected "6fm7" [edit=sysop:move=sysop]

OCA — Wed, 07 Feb 2018 05:18:38 GMT

Protected "6fm7" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 7 February 2018

OCA: New page: '''Unreleased structure''' The entry 6fm7 is ON HOLD until Paper Publication Authors: Pozzi, C., De Luca, F., Benvenuti, M., Di Pisa, F., Docquier, J.D., Mangani, S. Description: Cryst...

OCA — Wed, 07 Feb 2018 05:18:37 GMT

New page: '''Unreleased structure''' The entry 6fm7 is ON HOLD until Paper Publication Authors: Pozzi, C., De Luca, F., Benvenuti, M., Di Pisa, F., Docquier, J.D., Mangani, S. Description: Cryst...

New page

'''Unreleased structure'''

The entry 6fm7 is ON HOLD until Paper Publication

Authors: Pozzi, C., De Luca, F., Benvenuti, M., Di Pisa, F., Docquier, J.D., Mangani, S.

Description: Crystal structure of the class C beta-lactamase TRU-1 from Aeromonas enteropelogenes in complex with avibactam
[[Category: Unreleased Structures]]
[[Category: Benvenuti, M]]
[[Category: De Luca, F]]
[[Category: Mangani, S]]
[[Category: Docquier, J.D]]
[[Category: Di Pisa, F]]
[[Category: Pozzi, C]]