OCA at 07:22, 25 July 2018

OCA — Wed, 25 Jul 2018 07:22:33 GMT

←Older revision		Revision as of 07:22, 25 July 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6fnn is ~~ON HOLD~~	+	==Caldiarchaeum Subterraneum Ubiquitin:Rpn11-homolog complex==
		+	<StructureSection load='6fnn' size='340' side='right' caption='[[6fnn]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fnn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FNN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnn OCA], [http://pdbe.org/6fnn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fnn RCSB], [http://www.ebi.ac.uk/pdbsum/6fnn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnn ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	While protein ubiquitination was long believed to be a truly eukaryotic feature, recently sequenced genomes revealed complete ubiquitin (Ub) modification operons in archaea. Here, we present the structural and mechanistic characterization of an archaeal Rpn11 deubiquitinase from Caldiarchaeum subterraneum, CsRpn11, and its role in the processing of CsUb precursor and ubiquitinated proteins. CsRpn11 activity is affected by the catalytic metal ion type, small molecule inhibitors, sequence characteristics at the cleavage site, and the folding state of CsUb-conjugated proteins. Comparison of CsRpn11 and CsRpn11-CsUb crystal structures reveals a crucial conformational switch in the CsRpn11 Ins-1 site, which positions CsUb for catalysis. The presence of this transition in a primordial soluble Rpn11 thus predates the evolution of eukaryotic Rpn11 immobilized in the proteasomal lid. Complementing phylogenetic studies, which designate CsRpn11 and CsUb as close homologs of the respective eukaryotic proteins, our results provide experimental support for an archaeal origin of protein ubiquitination.

-	~~Authors~~:	+	Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system.,Fuchs ACD, Maldoner L, Wojtynek M, Hartmann MD, Martin J Nat Commun. 2018 Jul 12;9(1):2696. doi: 10.1038/s41467-018-05198-1. PMID:30002364<ref>PMID:30002364</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6fnn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ubiquitinyl hydrolase 1]]
		+	[[Category: Albrecht, R]]
		+	[[Category: Fuchs, A C.D]]
		+	[[Category: Hartmann, M D]]
		+	[[Category: Martin, J]]
		+	[[Category: Deubiquitination]]
		+	[[Category: Deubiquitylation]]
		+	[[Category: Hydrolase]]
		+	[[Category: Jamm protease]]

OCA: Protected "6fnn" [edit=sysop:move=sysop]

OCA — Thu, 15 Feb 2018 05:28:12 GMT

Protected "6fnn" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:28, 15 February 2018

OCA: New page: '''Unreleased structure''' The entry 6fnn is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 15 Feb 2018 05:28:11 GMT

New page: '''Unreleased structure''' The entry 6fnn is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fnn is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6fnn - Revision history

OCA at 07:22, 25 July 2018

OCA: Protected "6fnn" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6fnn is ON HOLD Authors: Description: Category: Unreleased Structures