6fnu - Revision history

OCA at 12:30, 9 May 2024

OCA — Thu, 09 May 2024 12:30:05 GMT

←Older revision		Revision as of 12:30, 9 May 2024
Line 1:		Line 1:

	==Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain==		==Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain==
-	<StructureSection load='6fnu' size='340' side='right' caption='[[6fnu]], [[Resolution\|resolution]] 1.56Å' scene=''>	+	<StructureSection load='6fnu' size='340' side='right'caption='[[6fnu]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fnu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FNU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fnu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FNU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.56Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">MET12, YPL023C, LPB8C ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>[http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase_(NAD(P)H) Methylenetetrahydrofolate reductase (NAD(P)H)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.20 1.5.1.20] </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnu OCA], [https://pdbe.org/6fnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fnu RCSB], [https://www.ebi.ac.uk/pdbsum/6fnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnu OCA], [~~http~~://pdbe.org/6fnu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fnu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fnu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MTHR1_YEAST MTHR1_YEAST]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6fnu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6fnu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Methylenetetrahydrofolate reductase 3D structures\|Methylenetetrahydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 18824~~]]	+	[[Category: Large Structures]]
-	[[Category: Baumgartner, M]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Bezerra~~, G A~~]]	+	[[Category: Baumgartner M]]
-	[[Category: Bountra, C]]	+	[[Category: Bezerra GA]]
-	[[Category: Froese~~, D S~~]]	+	[[Category: Bountra C]]
-	[[Category: Kopec, J]]	+	[[Category: Froese DS]]
-	[[Category: Newman, J]]	+	[[Category: Kopec J]]
-	[[Category: Rembeza, E]]	+	[[Category: Newman J]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Rembeza E]]
-	[[Category: Yue~~, W W]]~~	+	[[Category: Yue WW]]
-	~~[[Category: Folate metabolism]]~~	+
-	~~[[Category: One carbon metabolism]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Reductase]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 07:43, 4 July 2018

OCA — Wed, 04 Jul 2018 07:43:37 GMT

←Older revision		Revision as of 07:43, 4 July 2018
Line 3:		Line 3:
	<StructureSection load='6fnu' size='340' side='right' caption='[[6fnu]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='6fnu' size='340' side='right' caption='[[6fnu]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fnu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FNU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fnu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FNU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MET12, YPL023C, LPB8C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase_(NAD(P)H) Methylenetetrahydrofolate reductase (NAD(P)H)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.20 1.5.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase_(NAD(P)H) Methylenetetrahydrofolate reductase (NAD(P)H)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.20 1.5.1.20] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnu OCA], [http://pdbe.org/6fnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fnu RCSB], [http://www.ebi.ac.uk/pdbsum/6fnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnu OCA], [http://pdbe.org/6fnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fnu RCSB], [http://www.ebi.ac.uk/pdbsum/6fnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnu ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The folate and methionine cycles are crucial for biosynthesis of lipids, nucleotides and proteins, and production of the methyl donor S-adenosylmethionine (SAM). 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a key regulatory connection between these cycles, generating 5-methyltetrahydrofolate for initiation of the methionine cycle, and undergoing allosteric inhibition by its end product SAM. Our 2.5 A resolution crystal structure of human MTHFR reveals a unique architecture, appending the well-conserved catalytic TIM-barrel to a eukaryote-only SAM-binding domain. The latter domain of novel fold provides the predominant interface for MTHFR homo-dimerization, positioning the N-terminal serine-rich phosphorylation region near the C-terminal SAM-binding domain. This explains how MTHFR phosphorylation, identified on 11 N-terminal residues (16 in total), increases sensitivity to SAM binding and inhibition. Finally, we demonstrate that the 25-amino-acid inter-domain linker enables conformational plasticity and propose it to be a key mediator of SAM regulation. Together, these results provide insight into the molecular regulation of MTHFR.
		+
		+	Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.,Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW Nat Commun. 2018 Jun 11;9(1):2261. doi: 10.1038/s41467-018-04735-2. PMID:29891918<ref>PMID:29891918</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6fnu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Baumgartner, M]]		[[Category: Baumgartner, M]]
	[[Category: Bezerra, G A]]		[[Category: Bezerra, G A]]

OCA at 05:11, 8 March 2018

OCA — Thu, 08 Mar 2018 05:11:40 GMT

←Older revision		Revision as of 05:11, 8 March 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6fnu is ON HOLD~~	+	==Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain==
-		+	<StructureSection load='6fnu' size='340' side='right' caption='[[6fnu]], [[Resolution\|resolution]] 1.56Å' scene=''>
-	~~Authors: Kopec, J~~., ~~Rembeza~~, E.~~, Bezerra, G~~.A.~~, Newman, J~~.~~, Bountra, C~~.~~, Froese, D~~.S.~~, Baumgartner, M~~.~~, Yue, W~~.W.~~, Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fnu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FNU FirstGlance]. <br>
-	~~Description~~: ~~Structure of S~~. ~~cerevisiae~~ Methylenetetrahydrofolate reductase 1, ~~catalytic domain~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures]~~]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase_(NAD(P)H) Methylenetetrahydrofolate reductase (NAD(P)H)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.20 1.5.1.20] </span></td></tr>
-	[[~~Category~~: ~~Bezerra~~, G.A]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnu OCA], [http://pdbe.org/6fnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fnu RCSB], [http://www.ebi.ac.uk/pdbsum/6fnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnu ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Yue~~, W.W]]	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Baumgartner, M]]		[[Category: Baumgartner, M]]
		+	[[Category: Bezerra, G A]]
		+	[[Category: Bountra, C]]
		+	[[Category: Froese, D S]]
	[[Category: Kopec, J]]		[[Category: Kopec, J]]
	[[Category: Newman, J]]		[[Category: Newman, J]]
-	[[Category: Froese, D.S]]
-	[[Category: Structural Genomics Consortium (Sgc)]]
	[[Category: Rembeza, E]]		[[Category: Rembeza, E]]
-	[[Category: ~~Bountra~~, C]]	+	[[Category: Structural genomic]]
		+	[[Category: Yue, W W]]
		+	[[Category: Folate metabolism]]
		+	[[Category: One carbon metabolism]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Reductase]]
		+	[[Category: Sgc]]
		+	[[Category: Tim barrel]]

OCA: Protected "6fnu" [edit=sysop:move=sysop]

OCA — Thu, 15 Feb 2018 05:28:35 GMT

Protected "6fnu" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:28, 15 February 2018

OCA: New page: '''Unreleased structure''' The entry 6fnu is ON HOLD Authors: Kopec, J., Rembeza, E., Bezerra, G.A., Newman, J., Bountra, C., Froese, D.S., Baumgartner, M., Yue, W.W., Structural Genomi...

OCA — Thu, 15 Feb 2018 05:28:34 GMT

New page: '''Unreleased structure''' The entry 6fnu is ON HOLD Authors: Kopec, J., Rembeza, E., Bezerra, G.A., Newman, J., Bountra, C., Froese, D.S., Baumgartner, M., Yue, W.W., Structural Genomi...

New page

'''Unreleased structure'''

The entry 6fnu is ON HOLD

Authors: Kopec, J., Rembeza, E., Bezerra, G.A., Newman, J., Bountra, C., Froese, D.S., Baumgartner, M., Yue, W.W., Structural Genomics Consortium (SGC)

Description: Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain
[[Category: Unreleased Structures]]
[[Category: Bezerra, G.A]]
[[Category: Yue, W.W]]
[[Category: Baumgartner, M]]
[[Category: Kopec, J]]
[[Category: Newman, J]]
[[Category: Froese, D.S]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Rembeza, E]]
[[Category: Bountra, C]]