OCA at 07:51, 20 March 2019

OCA — Wed, 20 Mar 2019 07:51:06 GMT

←Older revision		Revision as of 07:51, 20 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6fta is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-3098==
-		+	<StructureSection load='6fta' size='340' side='right'caption='[[6fta]], [[Resolution\|resolution]] 2.34Å' scene=''>
-	~~Authors~~: ~~Singh~~, A.K., ~~Brown~~, D.G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fta]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FTA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FTA FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~human phosphodiesterase 4D2 catalytic domain~~ with ~~inhibitor NPD~~-~~3098~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E6N:(4~{a}~{S},8~{a}~{S})-4-[4-methoxy-3-[(2-methoxyphenyl)methoxy]phenyl]-2-[1-(3-nitroimidazo[1,2-b]pyridazin-6-yl)piperidin-4-yl]-4~{a},5,6,7,8,8~{a}-hexahydrophthalazin-1-one'>E6N</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6frd\|6frd]], [[6ft0\|6ft0]]</td></tr>
-	[[Category: Brown, D.G]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
-	[[Category: Singh, A.K]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fta OCA], [http://pdbe.org/6fta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fta RCSB], [http://www.ebi.ac.uk/pdbsum/6fta PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fta ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[http://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
		+	[[Category: Large Structures]]
		+	[[Category: Brown, D G]]
		+	[[Category: Singh, A K]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Camp hydrolysis]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phosphodiesterase]]

OCA: Protected "6fta" [edit=sysop:move=sysop]

OCA — Wed, 28 Feb 2018 05:14:20 GMT

Protected "6fta" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:14, 28 February 2018

OCA: New page: '''Unreleased structure''' The entry 6fta is ON HOLD until Paper Publication Authors: Singh, A.K., Brown, D.G. Description: Crystal structure of human phosphodiesterase 4D2 catalytic d...

OCA — Wed, 28 Feb 2018 05:14:18 GMT

New page: '''Unreleased structure''' The entry 6fta is ON HOLD until Paper Publication Authors: Singh, A.K., Brown, D.G. Description: Crystal structure of human phosphodiesterase 4D2 catalytic d...

New page

'''Unreleased structure'''

The entry 6fta is ON HOLD until Paper Publication

Authors: Singh, A.K., Brown, D.G.

Description: Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-3098
[[Category: Unreleased Structures]]
[[Category: Brown, D.G]]
[[Category: Singh, A.K]]

6fta - Revision history

OCA at 07:51, 20 March 2019

OCA: Protected "6fta" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6fta is ON HOLD until Paper Publication Authors: Singh, A.K., Brown, D.G. Description: Crystal structure of human phosphodiesterase 4D2 catalytic d...