6fto - Revision history

OCA at 08:12, 21 May 2019

OCA — Tue, 21 May 2019 08:12:46 GMT

←Older revision		Revision as of 08:12, 21 May 2019
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	<StructureSection load='6fto' size='340' side='right'caption='[[6fto]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6fto' size='340' side='right'caption='[[6fto]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fto]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FTO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fto]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FTO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fto OCA], [http://pdbe.org/6fto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fto RCSB], [http://www.ebi.ac.uk/pdbsum/6fto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fto ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fto OCA], [http://pdbe.org/6fto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fto RCSB], [http://www.ebi.ac.uk/pdbsum/6fto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fto ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 356]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Leopold, K]]		[[Category: Leopold, K]]

OCA at 06:34, 27 March 2019

OCA — Wed, 27 Mar 2019 06:34:25 GMT

←Older revision		Revision as of 06:34, 27 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6fto is ~~ON HOLD~~	+	==Crystal structure of the Chp2 chromoshadow domain in complex with N-terminal domain of chromatin remodeler Mit1==
		+	<StructureSection load='6fto' size='340' side='right'caption='[[6fto]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fto]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FTO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fto OCA], [http://pdbe.org/6fto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fto RCSB], [http://www.ebi.ac.uk/pdbsum/6fto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fto ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CHP2_SCHPO CHP2_SCHPO]] Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation.<ref>PMID:10835380</ref> [[http://www.uniprot.org/uniprot/MIT1_SCHPO MIT1_SCHPO]] Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).<ref>PMID:17289569</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heterochromatin protein 1 (HP1) proteins are key factors of eukaryotic heterochromatin that coordinate chromatin compaction and transcriptional gene silencing. Through their multivalency they act as adaptors between histone H3 Lys9 di/trimethyl marks in chromatin and effector complexes that bind to the HP1 chromoshadow domain. Most organisms encode for multiple HP1 isoforms and the molecular mechanisms that underpin their diverse functions in genome regulation remain poorly understood. In fission yeast, the two HP1 proteins Chp2 and Swi6 assume distinct roles and Chp2 is tightly associated with the nucleosome remodeling and deacetylation complex SHREC. Here we show that Chp2 directly engages the SHREC nucleosome remodeler subunit Mit1. The crystal structure of the interaction interface reveals an extraordinarily extensive and specific interaction between the chromoshadow domain of Chp2 and the N terminus of Mit1. The integrity of this interface is critical for high affinity binding and for heterochromatin formation. Comparison with Swi6 shows that the Chp2-Mit1 interface is highly selective and thereby provides the molecular basis for the functional specialization of an HP1 isoform.

-	~~Authors~~:	+	Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1.,Leopold K, Stirpe A, Schalch T Genes Dev. 2019 Feb 26. pii: gad.320440.118. doi: 10.1101/gad.320440.118. PMID:30808655<ref>PMID:30808655</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6fto" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Leopold, K]]
		+	[[Category: Schalch, T]]
		+	[[Category: Chromatin remodeler]]
		+	[[Category: Chromoshadow domain]]
		+	[[Category: Complex]]
		+	[[Category: Replication]]

OCA at 03:55, 8 March 2018

OCA — Thu, 08 Mar 2018 03:55:47 GMT

←Older revision		Revision as of 03:55, 8 March 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6fto is ON HOLD ~~until sometime in the future~~	+	The entry 6fto is ON HOLD

	Authors:		Authors:

OCA: Protected "6fto" [edit=sysop:move=sysop]

OCA — Wed, 28 Feb 2018 05:15:17 GMT

Protected "6fto" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:15, 28 February 2018

OCA: New page: '''Unreleased structure''' The entry 6fto is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Feb 2018 05:15:16 GMT

New page: '''Unreleased structure''' The entry 6fto is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fto is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]