6fur - Revision history

OCA at 06:37, 9 May 2018

OCA — Wed, 09 May 2018 06:37:34 GMT

←Older revision		Revision as of 06:37, 9 May 2018
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fur OCA], [http://pdbe.org/6fur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fur RCSB], [http://www.ebi.ac.uk/pdbsum/6fur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fur ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fur OCA], [http://pdbe.org/6fur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fur RCSB], [http://www.ebi.ac.uk/pdbsum/6fur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fur ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major histocompatibility complexes (pMHCs). The nature of the interaction between these two proteins has been the subject of many investigations because of its central role in immunity against pathogens, cancer, in autoimmunity, and during organ transplant rejection. Crystal structures comparing unbound and pMHC-bound TCRs have revealed flexibility at the interaction interface, particularly from the perspective of the TCR. However, crystal structures represent only a snapshot of protein conformation that could be influenced through biologically irrelevant crystal lattice contacts and other factors. Here, we solved the structures of three unbound TCRs from multiple crystals. Superposition of identical TCR structures from different crystals revealed some conformation differences of up to 5 A in individual complementarity determining region (CDR) loops that are similar to those that have previously been attributed to antigen engagement. We then used a combination of rigidity analysis and simulations of protein motion to reveal the theoretical potential of TCR CDR loop flexibility in unbound state. These simulations of protein motion support the notion that crystal structures may only offer an artifactual indication of TCR flexibility, influenced by crystallization conditions and crystal packing that is inconsistent with the theoretical potential of intrinsic TCR motions.
		+
		+	In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.,Holland CJ, MacLachlan BJ, Bianchi V, Hesketh SJ, Morgan R, Vickery O, Bulek AM, Fuller A, Godkin A, Sewell AK, Rizkallah PJ, Wells S, Cole DK Front Immunol. 2018 Apr 11;9:674. doi: 10.3389/fimmu.2018.00674. eCollection, 2018. PMID:29696015<ref>PMID:29696015</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6fur" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:53, 18 April 2018

OCA — Wed, 18 Apr 2018 05:53:01 GMT

←Older revision		Revision as of 05:53, 18 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6fur is ~~ON HOLD~~	+	==F11 T-Cell Receptor Recognising PKYVKQNTLKLAT Peptide Presented by HLA-DR*0101==
-		+	<StructureSection load='6fur' size='340' side='right' caption='[[6fur]], [[Resolution\|resolution]] 1.73Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fur]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FUR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fur OCA], [http://pdbe.org/6fur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fur RCSB], [http://www.ebi.ac.uk/pdbsum/6fur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fur ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cole, D K]]
		+	[[Category: Rizkallah, P J]]
		+	[[Category: 3d structure]]
		+	[[Category: Haemagglutinin]]
		+	[[Category: Human leukocyte antigen]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza epitope]]
		+	[[Category: T cell receptor]]

OCA: Protected "6fur" [edit=sysop:move=sysop]

OCA — Thu, 08 Mar 2018 03:58:42 GMT

Protected "6fur" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:58, 8 March 2018

OCA: New page: '''Unreleased structure''' The entry 6fur is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 08 Mar 2018 03:58:41 GMT

New page: '''Unreleased structure''' The entry 6fur is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fur is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]