6fwr - Revision history

OCA at 12:31, 9 May 2024

OCA — Thu, 09 May 2024 12:31:38 GMT

←Older revision		Revision as of 12:31, 9 May 2024
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	==Structure of DinG in complex with ssDNA==		==Structure of DinG in complex with ssDNA==
-	<StructureSection load='6fwr' size='340' side='right' caption='[[6fwr]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='6fwr' size='340' side='right'caption='[[6fwr]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fwr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FWR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fwr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FWR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fwr OCA], [~~http~~://pdbe.org/6fwr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fwr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fwr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fwr ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fwr OCA], [https://pdbe.org/6fwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fwr RCSB], [https://www.ebi.ac.uk/pdbsum/6fwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fwr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~A0A2H4TNL0_ECOLX A0A2H4TNL0_ECOLX]~~] DNA-dependent ATPase and 5'-3' DNA helicase.~~[HAMAP~~-~~Rule~~:~~MF_02205]~~	+	[https://www.uniprot.org/uniprot/DING_ECOLI DING_ECOLI] DNA-dependent ATPase and 5'-3' DNA helicase (PubMed:12748189, PubMed:17416902). Can also unwind DNA-RNA hybrid duplexes. Is active on D-loops and R-loops, and on forked structures (PubMed:17416902). May be involved in recombinational DNA repair and the resumption of replication after DNA damage (PubMed:17416902). The redox cluster is involved in DNA-mediated charge-transport signaling between DNA repair proteins from distinct pathways. DinG cooperates at long-range with endonuclease III, a base excision repair enzyme, using DNA charge transport to redistribute to regions of DNA damage (PubMed:24738733).<ref>PMID:12748189</ref> <ref>PMID:17416902</ref> <ref>PMID:24738733</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6fwr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6fwr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cheng, K~~]]	+	[[Category: Escherichia coli]]
-	[[Category: ~~Wigley, D B~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Atp~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Dna binding protein~~]]	+	[[Category: Cheng K]]
-	[[Category: ~~Helicase]]~~	+	[[Category: Wigley DB]]
-	~~[[Category: Translocase~~]]	+

OCA at 08:27, 19 December 2018

OCA — Wed, 19 Dec 2018 08:27:03 GMT

←Older revision		Revision as of 08:27, 19 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6fwr is ~~ON HOLD~~	+	==Structure of DinG in complex with ssDNA==
		+	<StructureSection load='6fwr' size='340' side='right' caption='[[6fwr]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6fwr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FWR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fwr OCA], [http://pdbe.org/6fwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fwr RCSB], [http://www.ebi.ac.uk/pdbsum/6fwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fwr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A2H4TNL0_ECOLX A0A2H4TNL0_ECOLX]] DNA-dependent ATPase and 5'-3' DNA helicase.[HAMAP-Rule:MF_02205]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The XPD family of helicases, that includes human disease-related FANCJ, DDX11 and RTEL1, are Superfamily 2 helicases that contain an iron-sulphur cluster domain, translocate on ssDNA in a 5'-3' direction and play important roles in genome stability. Consequently, mutations in several of these family members in eukaryotes cause human diseases. Family members in bacteria, such as the DinG helicase from Escherichia coli, are also involved in DNA repair. Here we present crystal structures of complexes of DinG bound to single-stranded DNA (ssDNA) in the presence and absence of an ATP analogue (ADP*BeF3), that suggest a mechanism for 5'-3' translocation along the ssDNA substrate. This proposed mechanism has implications for how those enzymes of the XPD family that recognise bulky DNA lesionsmight stall at these as the first step in initiating DNA repair. Biochemical data reveal roles for conserved residues that are mutated in human diseases.

-	~~Authors~~:	+	DNA translocation mechanism of an XPD family helicase.,Cheng K, Wigley DB Elife. 2018 Dec 6;7. pii: 42400. doi: 10.7554/eLife.42400. PMID:30520735<ref>PMID:30520735</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6fwr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cheng, K]]
		+	[[Category: Wigley, D B]]
		+	[[Category: Atp]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Helicase]]
		+	[[Category: Translocase]]

OCA: Protected "6fwr" [edit=sysop:move=sysop]

OCA — Wed, 14 Mar 2018 05:18:21 GMT

Protected "6fwr" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 14 March 2018

OCA: New page: '''Unreleased structure''' The entry 6fwr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Mar 2018 05:18:20 GMT

New page: '''Unreleased structure''' The entry 6fwr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fwr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]