6fxp - Revision history

OCA at 12:31, 9 May 2024

OCA — Thu, 09 May 2024 12:31:56 GMT

←Older revision		Revision as of 12:31, 9 May 2024
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	<StructureSection load='6fxp' size='340' side='right'caption='[[6fxp]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='6fxp' size='340' side='right'caption='[[6fxp]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fxp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Staam Staam~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FXP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6FXP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fxp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FXP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAV1775 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6fxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fxp OCA], [~~http~~://pdbe.org/6fxp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fxp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fxp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fxp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fxp OCA], [https://pdbe.org/6fxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fxp RCSB], [https://www.ebi.ac.uk/pdbsum/6fxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fxp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3JSV1_STAAM A0A0H3JSV1_STAAM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staam~~]]	+	[[Category: Staphylococcus aureus subsp. aureus Mu50]]
-	[[Category: Pintar, S]]	+	[[Category: Pintar S]]
-	[[Category: Turk, D]]	+	[[Category: Turk D]]
-	~~[[Category: Gh73]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lysozyme-like fold]]~~	+
-	~~[[Category: N-acetylglucosaminidase]]~~	+
-	~~[[Category: Peptidoglycan hydrolase~~]]	+

OCA at 07:16, 30 September 2020

OCA — Wed, 30 Sep 2020 07:16:56 GMT

←Older revision		Revision as of 07:16, 30 September 2020
Line 3:		Line 3:
	<StructureSection load='6fxp' size='340' side='right'caption='[[6fxp]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='6fxp' size='340' side='right'caption='[[6fxp]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fxp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FXP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FXP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fxp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FXP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6FXP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fxp OCA], [http://pdbe.org/6fxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fxp RCSB], [http://www.ebi.ac.uk/pdbsum/6fxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fxp ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAV1775 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6fxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fxp OCA], [http://pdbe.org/6fxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fxp RCSB], [http://www.ebi.ac.uk/pdbsum/6fxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fxp ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To achieve productive binding, enzymes and substrates must align their geometries to complement each other along an entire substrate binding site, which may require enzyme flexibility. In pursuit of novel drug targets for the human pathogen S. aureus, we studied peptidoglycan N-acetylglucosaminidases, whose structures are composed of two domains forming a V-shaped active site cleft. Combined insights from crystal structures supported by site-directed mutagenesis, modeling, and molecular dynamics enabled us to elucidate the substrate binding mechanism of SagB and AtlA-gl. This mechanism requires domain sliding from the open form observed in their crystal structures, leading to polysaccharide substrate binding in the closed form, which can enzymatically process the bound substrate. We suggest that these two hydrolases must exhibit unusual extents of flexibility to cleave the rigid structure of a bacterial cell wall.
		+
		+	Domain sliding of two Staphylococcus aureus N-acetylglucosaminidases enables their substrate-binding prior to its catalysis.,Pintar S, Borisek J, Usenik A, Perdih A, Turk D Commun Biol. 2020 Apr 20;3(1):178. doi: 10.1038/s42003-020-0911-7. PMID:32313083<ref>PMID:32313083</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6fxp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Staam]]
	[[Category: Pintar, S]]		[[Category: Pintar, S]]
	[[Category: Turk, D]]		[[Category: Turk, D]]

OCA at 07:53, 20 March 2019

OCA — Wed, 20 Mar 2019 07:53:44 GMT

←Older revision		Revision as of 07:53, 20 March 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6fxp ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of S. aureus glucosaminidase B==
-		+	<StructureSection load='6fxp' size='340' side='right'caption='[[6fxp]], [[Resolution\|resolution]] 2.03Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fxp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FXP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fxp OCA], [http://pdbe.org/6fxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fxp RCSB], [http://www.ebi.ac.uk/pdbsum/6fxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fxp ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pintar, S]]
		+	[[Category: Turk, D]]
		+	[[Category: Gh73]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lysozyme-like fold]]
		+	[[Category: N-acetylglucosaminidase]]
		+	[[Category: Peptidoglycan hydrolase]]

OCA: Protected "6fxp" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2018 06:19:18 GMT

Protected "6fxp" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:19, 21 March 2018

OCA: New page: '''Unreleased structure''' The entry 6fxp is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Mar 2018 06:19:17 GMT

New page: '''Unreleased structure''' The entry 6fxp is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fxp is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]