6fzv - Revision history

OCA at 08:03, 29 August 2018

OCA — Wed, 29 Aug 2018 08:03:29 GMT

←Older revision		Revision as of 08:03, 29 August 2018
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	<StructureSection load='6fzv' size='340' side='right' caption='[[6fzv]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='6fzv' size='340' side='right' caption='[[6fzv]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6fzv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6fzv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FZV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COL3A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PCOLCE, PCPE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fzv OCA], [http://pdbe.org/6fzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fzv RCSB], [http://www.ebi.ac.uk/pdbsum/6fzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fzv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fzv OCA], [http://pdbe.org/6fzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fzv RCSB], [http://www.ebi.ac.uk/pdbsum/6fzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fzv ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CO3A1_HUMAN CO3A1_HUMAN]] Collagen type III occurs in most soft connective tissues along with type I collagen. [[http://www.uniprot.org/uniprot/PCOC1_HUMAN PCOC1_HUMAN]] Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.		[[http://www.uniprot.org/uniprot/CO3A1_HUMAN CO3A1_HUMAN]] Collagen type III occurs in most soft connective tissues along with type I collagen. [[http://www.uniprot.org/uniprot/PCOC1_HUMAN PCOC1_HUMAN]] Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Procollagen C-proteinase enhancer-1 (PCPE-1) is a secreted protein that specifically accelerates proteolytic release of the C-propeptides from fibrillar procollagens, a crucial step in fibril assembly. As such, it is a potential therapeutic target to improve tissue repair and prevent fibrosis, a major cause of mortality worldwide. Here we present the crystal structure of the active CUB1CUB2 fragment of PCPE-1 bound to the C-propeptide trimer of procollagen III (CPIII). This shows that the two CUB domains bind to two different chains of CPIII and that the N-terminal region of one CPIII chain, close to the proteolytic cleavage site, lies in the cleft between CUB1 and CUB2. This suggests that enhancing activity involves unraveling of this chain from the rest of the trimer, thus facilitating the action of the proteinase involved. Support for this hypothesis comes from site-directed mutagenesis, enzyme assays, binding studies, and molecular modeling.
		+
		+	Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1.,Pulido D, Sharma U, Vadon-Le Goff S, Hussain SA, Cordes S, Mariano N, Bettler E, Moali C, Aghajari N, Hohenester E, Hulmes DJS Structure. 2018 Jul 12. pii: S0969-2126(18)30243-0. doi:, 10.1016/j.str.2018.06.011. PMID:30078642<ref>PMID:30078642</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6fzv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Hohenester, E]]		[[Category: Hohenester, E]]
	[[Category: Pulido, D]]		[[Category: Pulido, D]]
	[[Category: Collagen]]		[[Category: Collagen]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 07:20, 4 July 2018

OCA — Wed, 04 Jul 2018 07:20:32 GMT

←Older revision		Revision as of 07:20, 4 July 2018
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-	'''Unreleased structure'''

-	The entry ~~6fzv~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of the metalloproteinase enhancer PCPE-1 bound to the procollagen C propeptide trimer (short)==
-		+	<StructureSection load='6fzv' size='340' side='right' caption='[[6fzv]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6fzv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FZV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fzv OCA], [http://pdbe.org/6fzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fzv RCSB], [http://www.ebi.ac.uk/pdbsum/6fzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fzv ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CO3A1_HUMAN CO3A1_HUMAN]] Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM:[http://omim.org/entry/130020 130020]]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity.<ref>PMID:7833919</ref> Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [MIM:[http://omim.org/entry/130050 130050]]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.<ref>PMID:1370809</ref> <ref>PMID:8411057</ref> <ref>PMID:2492273</ref> <ref>PMID:7749417</ref> <ref>PMID:1352273</ref> <ref>PMID:2808425</ref> <ref>PMID:1895316</ref> <ref>PMID:1357232</ref> <ref>PMID:1496983</ref> <ref>PMID:8098182</ref> [:]<ref>PMID:7912131</ref> <ref>PMID:8019562</ref> [:]<ref>PMID:8680408</ref> <ref>PMID:8884076</ref> <ref>PMID:9147870</ref> <ref>PMID:8664902</ref> <ref>PMID:8990011</ref> <ref>PMID:9036918</ref> <ref>PMID:9452103</ref> <ref>PMID:10923041</ref> <ref>PMID:10706896</ref> <ref>PMID:11168790</ref> <ref>PMID:12694234</ref> <ref>PMID:12786757</ref> Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM:[http://omim.org/entry/100070 100070]]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells.<ref>PMID:8514866</ref> <ref>PMID:2243125</ref> <ref>PMID:2349939</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CO3A1_HUMAN CO3A1_HUMAN]] Collagen type III occurs in most soft connective tissues along with type I collagen. [[http://www.uniprot.org/uniprot/PCOC1_HUMAN PCOC1_HUMAN]] Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hohenester, E]]
		+	[[Category: Pulido, D]]
		+	[[Category: Collagen]]
		+	[[Category: Structural protein]]

OCA at 05:26, 28 March 2018

OCA — Wed, 28 Mar 2018 05:26:07 GMT

←Older revision		Revision as of 05:26, 28 March 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6fzv is ON HOLD	+	The entry 6fzv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6fzv" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2018 06:24:59 GMT

Protected "6fzv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:24, 21 March 2018

OCA: New page: '''Unreleased structure''' The entry 6fzv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Mar 2018 06:24:58 GMT

New page: '''Unreleased structure''' The entry 6fzv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fzv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]