OCA at 06:21, 2 January 2019

OCA — Wed, 02 Jan 2019 06:21:04 GMT

←Older revision		Revision as of 06:21, 2 January 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6g0j is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Inactive Fe-PP1==
		+	<StructureSection load='6g0j' size='340' side='right' caption='[[6g0j]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6g0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G0J FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP1CA, PPP1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g0j OCA], [http://pdbe.org/6g0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g0j RCSB], [http://www.ebi.ac.uk/pdbsum/6g0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g0j ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PP1A_HUMAN PP1A_HUMAN]] Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development.<ref>PMID:17283141</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein phosphatase-1 (PP1) drives a large amount of phosphoSer/Thr protein dephosphorylations in eukaryotes to counteract multiple kinases in signaling pathways. The phosphatase requires divalent metal cations for catalytic activity and contains iron naturally. Iron has been suggested to have an influence on PP1 activity through Fe(2+) and Fe(3+) oxidation states. However, much biochemical and all structural data have been obtained with recombinant PP1 containing Mn(2+) ions. Purifying iron-containing PP1 from Escherichia coli has thus far not been possible. Here, we present the preparation, characterization, and structure of iron-bound PP1alpha in inactive and active states. We establish a key role for the electronic/redox properties of iron in PP1 activity and shed light on the difference in substrate specificity between iron- and manganese-containing PP1.

-	~~Authors~~:	+	Effects of stably incorporated iron on protein phosphatase-1 structure and activity.,Salvi F, Trebacz M, Kokot T, Hoermann B, Rios P, Barabas O, Khn M FEBS Lett. 2018 Dec;592(24):4028-4038. doi: 10.1002/1873-3468.13284. Epub 2018, Nov 23. PMID:30403291<ref>PMID:30403291</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6g0j" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Phosphoprotein phosphatase]]
		+	[[Category: Barabas, O]]
		+	[[Category: Koehn, M]]
		+	[[Category: Salvi, F]]
		+	[[Category: Cell cycle]]
		+	[[Category: Hydrolase]]
		+	[[Category: Iron]]
		+	[[Category: Oxidative stress]]
		+	[[Category: Phosphatase]]

OCA at 04:46, 4 April 2018

OCA — Wed, 04 Apr 2018 04:46:45 GMT

←Older revision		Revision as of 04:46, 4 April 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6g0j is ON HOLD	+	The entry 6g0j is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6g0j" [edit=sysop:move=sysop]

OCA — Wed, 28 Mar 2018 05:27:06 GMT

Protected "6g0j" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 28 March 2018

OCA: New page: '''Unreleased structure''' The entry 6g0j is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Mar 2018 05:27:05 GMT

New page: '''Unreleased structure''' The entry 6g0j is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6g0j is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6g0j - Revision history

OCA at 06:21, 2 January 2019

OCA at 04:46, 4 April 2018

OCA: Protected "6g0j" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6g0j is ON HOLD Authors: Description: Category: Unreleased Structures