OCA at 06:42, 18 October 2018

OCA — Thu, 18 Oct 2018 06:42:43 GMT

←Older revision		Revision as of 06:42, 18 October 2018
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6g0w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6g0w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:29, 23 May 2018

OCA — Wed, 23 May 2018 07:29:57 GMT

←Older revision		Revision as of 07:29, 23 May 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6g0w is ~~ON HOLD until Paper~~ Publication	+	==Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor MCD72==
		+	<StructureSection load='6g0w' size='340' side='right' caption='[[6g0w]], [[Resolution\|resolution]] 2.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6g0w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G0W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G0W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EGW:4-[3-[4-(4-fluorophenyl)piperidin-1-yl]carbonylphenoxy]benzamide'>EGW</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g0w OCA], [http://pdbe.org/6g0w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g0w RCSB], [http://www.ebi.ac.uk/pdbsum/6g0w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g0w ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PAR14_HUMAN PAR14_HUMAN]] Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A series of diaryl ethers were designed and synthesized to discern the structure activity relationships against the two closely related mono-(ADP-ribosyl)transferases PARP10 and PARP14. Structure activity studies identified 8b as a sub-micromolar inhibitor of PARP10 with approximately 15-fold selectivity over PARP14. In addition, 8k and 8m were discovered to have sub-micromolar potency against PARP14 and demonstrated moderate selectivity over PARP10. A crystal structure of the complex of PARP14 and 8b shows binding of the compound in a novel hydrophobic pocket and explains both potency and selectivity over other PARP family members. In addition, 8b, 8k and 8m also demonstrate selectivity over PARP1. Together, this study identified novel, potent and metabolically stable derivatives to use as chemical probes for these biologically interesting therapeutic targets.

-	~~Authors: Karlberg~~, ~~T., Thorsell, A.G~~., Holechek, J., Lease, R., ~~Ferraris~~, D., Schuler, H.	+	Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.,Holechek J, Lease R, Thorsell AG, Karlberg T, McCadden C, Grant R, Keen A, Callahan E, Schuler H, Ferraris D Bioorg Med Chem Lett. 2018 Jun 15;28(11):2050-2054. doi:, 10.1016/j.bmcl.2018.04.056. Epub 2018 May 3. PMID:29748053<ref>PMID:29748053</ref>

-	~~Description: Human PARP14 (ARTD8)~~, ~~catalytic fragment in complex with inhibitor MCD72~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Thorsell, A.G]]~~	+	<div class="pdbe-citations 6g0w" style="background-color:#fffaf0;"></div>
-	~~[[Category: Schuler, H]]~~	+	== References ==
-	~~[[Category: Holechek, J]]~~	+	<references/>
-	~~[[Category: Lease, R]]~~	+	__TOC__
		+	</StructureSection>
	[[Category: Ferraris, D]]		[[Category: Ferraris, D]]
		+	[[Category: Holechek, J]]
	[[Category: Karlberg, T]]		[[Category: Karlberg, T]]
		+	[[Category: Lease, R]]
		+	[[Category: Schuler, H]]
		+	[[Category: Thorsell, A G]]
		+	[[Category: Adp-ribosylation]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase domain]]

OCA: Protected "6g0w" [edit=sysop:move=sysop]

OCA — Wed, 28 Mar 2018 05:28:13 GMT

Protected "6g0w" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:28, 28 March 2018

OCA: New page: '''Unreleased structure''' The entry 6g0w is ON HOLD until Paper Publication Authors: Karlberg, T., Thorsell, A.G., Holechek, J., Lease, R., Ferraris, D., Schuler, H. Description: Huma...

OCA — Wed, 28 Mar 2018 05:28:11 GMT

New page: '''Unreleased structure''' The entry 6g0w is ON HOLD until Paper Publication Authors: Karlberg, T., Thorsell, A.G., Holechek, J., Lease, R., Ferraris, D., Schuler, H. Description: Huma...

New page

'''Unreleased structure'''

The entry 6g0w is ON HOLD until Paper Publication

Authors: Karlberg, T., Thorsell, A.G., Holechek, J., Lease, R., Ferraris, D., Schuler, H.

Description: Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor MCD72
[[Category: Unreleased Structures]]
[[Category: Thorsell, A.G]]
[[Category: Schuler, H]]
[[Category: Holechek, J]]
[[Category: Lease, R]]
[[Category: Ferraris, D]]
[[Category: Karlberg, T]]

6g0w - Revision history

OCA at 06:42, 18 October 2018

OCA at 07:29, 23 May 2018

OCA: Protected "6g0w" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6g0w is ON HOLD until Paper Publication Authors: Karlberg, T., Thorsell, A.G., Holechek, J., Lease, R., Ferraris, D., Schuler, H. Description: Huma...