6g1k - Revision history

OCA at 00:53, 11 April 2020

OCA — Sat, 11 Apr 2020 00:53:04 GMT

←Older revision		Revision as of 00:53, 11 April 2020
Line 3:		Line 3:
	<SX load='6g1k' size='340' side='right' viewer='molstar' caption='[[6g1k]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6g1k' size='340' side='right' viewer='molstar' caption='[[6g1k]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g1k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G1K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6G1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g1k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G1K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6G1K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44E:(2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL+DIHEXANOATE'>44E</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44E:(2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL+DIHEXANOATE'>44E</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpc4b, trpc4a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpc4b, trpc4a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6g1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g1k OCA], [http://pdbe.org/6g1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g1k RCSB], [http://www.ebi.ac.uk/pdbsum/6g1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g1k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6g1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g1k OCA], [http://pdbe.org/6g1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g1k RCSB], [http://www.ebi.ac.uk/pdbsum/6g1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g1k ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:27, 6 March 2020

OCA — Fri, 06 Mar 2020 21:27:47 GMT

←Older revision		Revision as of 21:27, 6 March 2020
Line 1:		Line 1:

	==Electron cryo-microscopy structure of the canonical TRPC4 ion channel==		==Electron cryo-microscopy structure of the canonical TRPC4 ion channel==
-	<~~StructureSection~~ load='6g1k' size='340' side='right' caption='[[6g1k]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<SX load='6g1k' size='340' side='right' viewer='molstar' caption='[[6g1k]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6g1k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G1K FirstGlance]. <br>		<table><tr><td colspan='2'>[[6g1k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G1K FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Apelbaum, A]]		[[Category: Apelbaum, A]]
	[[Category: Bothe, A]]		[[Category: Bothe, A]]

OCA at 19:10, 1 August 2018

OCA — Wed, 01 Aug 2018 19:10:52 GMT

←Older revision		Revision as of 19:10, 1 August 2018
Line 3:		Line 3:
	<StructureSection load='6g1k' size='340' side='right' caption='[[6g1k]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='6g1k' size='340' side='right' caption='[[6g1k]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g1k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g1k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G1K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44E:(2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL+DIHEXANOATE'>44E</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44E:(2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL+DIHEXANOATE'>44E</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpc4b, trpc4a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g1k OCA], [http://pdbe.org/6g1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g1k RCSB], [http://www.ebi.ac.uk/pdbsum/6g1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g1k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g1k OCA], [http://pdbe.org/6g1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g1k RCSB], [http://www.ebi.ac.uk/pdbsum/6g1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g1k ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Apelbaum, A]]		[[Category: Apelbaum, A]]
	[[Category: Bothe, A]]		[[Category: Bothe, A]]
-	[[Category: Gatsogiannis, G]]	+	[[Category: Gatsogiannis, C]]
	[[Category: Hofnagel, O]]		[[Category: Hofnagel, O]]
	[[Category: Mager, T]]		[[Category: Mager, T]]

OCA at 06:37, 9 May 2018

OCA — Wed, 09 May 2018 06:37:30 GMT

←Older revision		Revision as of 06:37, 9 May 2018
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g1k OCA], [http://pdbe.org/6g1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g1k RCSB], [http://www.ebi.ac.uk/pdbsum/6g1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g1k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g1k OCA], [http://pdbe.org/6g1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g1k RCSB], [http://www.ebi.ac.uk/pdbsum/6g1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g1k ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Canonical transient receptor channels (TRPC) are non-selective cation channels. They are involved in receptor-operated Ca(2+) signaling and have been proposed to act as store-operated channels (SOC). Their malfunction is related to cardiomyopathies and their modulation by small molecules has been shown to be effective against renal cancer cells. The molecular mechanism underlying the complex activation and regulation is poorly understood. Here, we report the electron cryo-microscopy structure of zebrafish TRPC4 in its unliganded (apo), closed state at an overall resolution of 3.6 A. The structure reveals the molecular architecture of the cation conducting pore, including the selectivity filter and lower gate. The cytoplasmic domain contains two key hubs that have been shown to interact with modulating proteins. Structural comparisons with other TRP channels give novel insights into the general architecture and domain organization of this superfamily of channels and help to understand their function and pharmacology.
		+
		+	Electron cryo-microscopy structure of the canonical TRPC4 ion channel.,Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S Elife. 2018 May 2;7. pii: 36615. doi: 10.7554/eLife.36615. PMID:29717981<ref>PMID:29717981</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6g1k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:17, 2 May 2018

OCA — Wed, 02 May 2018 08:17:50 GMT

←Older revision		Revision as of 08:17, 2 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6g1k ~~is ON HOLD until Paper Publication~~	+	==Electron cryo-microscopy structure of the canonical TRPC4 ion channel==
-		+	<StructureSection load='6g1k' size='340' side='right' caption='[[6g1k]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~: ~~Vinayagam, D~~.~~, Mager, T~~., ~~Apelbaum~~, A., ~~Bothe, A~~., ~~Merino, F~~., ~~Hofnagel, O~~., ~~Gatsogiannis, G~~., ~~Raunser, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6g1k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G1K FirstGlance]. <br>
-	~~Description~~: ~~Electron cryo-microscopy structure of the canonical TRPC4 ion channel~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44E:(2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL+DIHEXANOATE'>44E</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g1k OCA], [http://pdbe.org/6g1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g1k RCSB], [http://www.ebi.ac.uk/pdbsum/6g1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g1k ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Apelbaum, A]]
		+	[[Category: Bothe, A]]
		+	[[Category: Gatsogiannis, G]]
	[[Category: Hofnagel, O]]		[[Category: Hofnagel, O]]
-	[[Category: Apelbaum, A]]
	[[Category: Mager, T]]		[[Category: Mager, T]]
-	[[Category: Gatsogiannis, G]]
	[[Category: Merino, F]]		[[Category: Merino, F]]
		+	[[Category: Raunser, S]]
	[[Category: Vinayagam, D]]		[[Category: Vinayagam, D]]
-	[[Category: ~~Bothe, A~~]]	+	[[Category: Ankyrin repeat]]
-	[[Category: ~~Raunser, S~~]]	+	[[Category: Cirb domain]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]
		+	[[Category: Trpc4]]

OCA at 04:47, 4 April 2018

OCA — Wed, 04 Apr 2018 04:47:08 GMT

←Older revision		Revision as of 04:47, 4 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6g1k is ON HOLD	+	The entry 6g1k is ON HOLD until Paper Publication

	Authors: Vinayagam, D., Mager, T., Apelbaum, A., Bothe, A., Merino, F., Hofnagel, O., Gatsogiannis, G., Raunser, S.		Authors: Vinayagam, D., Mager, T., Apelbaum, A., Bothe, A., Merino, F., Hofnagel, O., Gatsogiannis, G., Raunser, S.
Line 7:		Line 7:
	Description: Electron cryo-microscopy structure of the canonical TRPC4 ion channel		Description: Electron cryo-microscopy structure of the canonical TRPC4 ion channel
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Merino, F]]
	[[Category: Hofnagel, O]]		[[Category: Hofnagel, O]]
	[[Category: Apelbaum, A]]		[[Category: Apelbaum, A]]
	[[Category: Mager, T]]		[[Category: Mager, T]]
	[[Category: Gatsogiannis, G]]		[[Category: Gatsogiannis, G]]
		+	[[Category: Merino, F]]
	[[Category: Vinayagam, D]]		[[Category: Vinayagam, D]]
	[[Category: Bothe, A]]		[[Category: Bothe, A]]
	[[Category: Raunser, S]]		[[Category: Raunser, S]]

OCA: Protected "6g1k" [edit=sysop:move=sysop]

OCA — Wed, 28 Mar 2018 05:30:07 GMT

Protected "6g1k" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:30, 28 March 2018

OCA: New page: '''Unreleased structure''' The entry 6g1k is ON HOLD Authors: Vinayagam, D., Mager, T., Apelbaum, A., Bothe, A., Merino, F., Hofnagel, O., Gatsogiannis, G., Raunser, S. Description: El...

OCA — Wed, 28 Mar 2018 05:30:05 GMT

New page: '''Unreleased structure''' The entry 6g1k is ON HOLD Authors: Vinayagam, D., Mager, T., Apelbaum, A., Bothe, A., Merino, F., Hofnagel, O., Gatsogiannis, G., Raunser, S. Description: El...

New page

'''Unreleased structure'''

The entry 6g1k is ON HOLD

Authors: Vinayagam, D., Mager, T., Apelbaum, A., Bothe, A., Merino, F., Hofnagel, O., Gatsogiannis, G., Raunser, S.

Description: Electron cryo-microscopy structure of the canonical TRPC4 ion channel
[[Category: Unreleased Structures]]
[[Category: Merino, F]]
[[Category: Hofnagel, O]]
[[Category: Apelbaum, A]]
[[Category: Mager, T]]
[[Category: Gatsogiannis, G]]
[[Category: Vinayagam, D]]
[[Category: Bothe, A]]
[[Category: Raunser, S]]