6g2a - Revision history

OCA at 07:05, 5 December 2018

OCA — Wed, 05 Dec 2018 07:05:18 GMT

←Older revision		Revision as of 07:05, 5 December 2018
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ADPRH_HUMAN ADPRH_HUMAN]] Catalyzes the reverse reaction of mono-ADP-ribosylation.		[[http://www.uniprot.org/uniprot/ADPRH_HUMAN ADPRH_HUMAN]] Catalyzes the reverse reaction of mono-ADP-ribosylation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein ADP-ribosylation is a highly dynamic post-translational modification. The rapid turnover is achieved, among others, by ADP-(ribosyl)hydrolases (ARHs), an ancient family of enzymes that reverses this modification. Recently ARHs came into focus due to their role as regulators of cellular stresses and tumor suppressors. Here we present a comprehensive structural analysis of the enzymatically active family members ARH1 and ARH3. These two enzymes have very distinct substrate requirements. Our data show that binding of the adenosine ribose moiety is highly diverged between the two enzymes, whereas the active sites harboring the distal ribose closely resemble each other. Despite this apparent similarity, we elucidate the structural basis for the selective inhibition of ARH3 by the ADP-ribose analogues ADP-HPD and arginine-ADP-ribose. Together, our biochemical and structural work provides important insights into the mode of enzyme-ligand interaction, helps to understand differences in their catalytic behavior, and provides useful tools for targeted drug design.
		+
		+	(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.,Rack JGM, Ariza A, Drown BS, Henfrey C, Bartlett E, Shirai T, Hergenrother PJ, Ahel I Cell Chem Biol. 2018 Nov 16. pii: S2451-9456(18)30389-1. doi:, 10.1016/j.chembiol.2018.11.001. PMID:30472116<ref>PMID:30472116</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6g2a" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:31, 2 December 2018

OCA — Sun, 02 Dec 2018 20:31:55 GMT

←Older revision		Revision as of 20:31, 2 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6g2a is ~~ON HOLD until Paper Publication~~	+	==Human [protein ADP-ribosylargenine] hydrolase ARH1 in complex with ADP-HPM==
-		+	<StructureSection load='6g2a' size='340' side='right' caption='[[6g2a]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6g2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G2A FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3R:Adenosine+Diphosphate+(Hydroxymethyl)pyrrolidine+monoalcohol'>A3R</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRH, ARH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Protein_ADP-ribosylarginine]_hydrolase [Protein ADP-ribosylarginine] hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.19 3.2.2.19] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2a OCA], [http://pdbe.org/6g2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g2a RCSB], [http://www.ebi.ac.uk/pdbsum/6g2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2a ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADPRH_HUMAN ADPRH_HUMAN]] Catalyzes the reverse reaction of mono-ADP-ribosylation.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Ariza, A]]
		+	[[Category: Adp-hpm]]
		+	[[Category: Adp-ribose]]
		+	[[Category: Adp-ribosylation]]
		+	[[Category: Adp-ribosylhydrolase]]
		+	[[Category: Adprh]]
		+	[[Category: Arh1]]
		+	[[Category: Hydrolase]]

OCA at 06:10, 17 October 2018

OCA — Wed, 17 Oct 2018 06:10:36 GMT

←Older revision		Revision as of 06:10, 17 October 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6g2a is ON HOLD	+	The entry 6g2a is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:10, 10 October 2018

OCA — Wed, 10 Oct 2018 06:10:08 GMT

←Older revision		Revision as of 06:10, 10 October 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6g2a is ON HOLD ~~until Paper Publication~~	+	The entry 6g2a is ON HOLD

	Authors:		Authors:

OCA at 04:47, 4 April 2018

OCA — Wed, 04 Apr 2018 04:47:50 GMT

←Older revision		Revision as of 04:47, 4 April 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6g2a is ON HOLD	+	The entry 6g2a is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6g2a" [edit=sysop:move=sysop]

OCA — Wed, 28 Mar 2018 05:31:47 GMT

Protected "6g2a" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:31, 28 March 2018

OCA: New page: '''Unreleased structure''' The entry 6g2a is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Mar 2018 05:31:46 GMT

New page: '''Unreleased structure''' The entry 6g2a is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6g2a is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]