OCA at 06:46, 26 June 2019

OCA — Wed, 26 Jun 2019 06:46:00 GMT

←Older revision		Revision as of 06:46, 26 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6g3t is ~~ON HOLD until Paper Publication~~	+	==X-ray structure of NSD3-PWWP1==
-		+	<StructureSection load='6g3t' size='340' side='right'caption='[[6g3t]], [[Resolution\|resolution]] 2.53Å' scene=''>
-	~~Authors~~: ~~Boettcher~~, J., ~~Muellauer~~, B.J., ~~Weiss~~-~~Puxbaum~~, A., ~~Zoephel~~, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6g3t]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G3T FirstGlance]. <br>
-	~~Description~~: X-~~ray structure of NSD3-PWWP1~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6g24\|6g24]], [[6g25\|6g25]], [[6g27\|6g27]], [[6g29\|6g29]], [[6g2b\|6g2b]], [[6g2c\|6g2c]], [[6g2e\|6g2e]], [[6g2f\|6g2f]], [[6g2o\|6g2o]], [[6g3p\|6g3p]]</td></tr>
-	[[~~Category~~: ~~Muellauer~~, B.J]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-	[[Category: ~~Zoephel, A~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g3t OCA], [http://pdbe.org/6g3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g3t RCSB], [http://www.ebi.ac.uk/pdbsum/6g3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g3t ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Histone-lysine N-methyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Boettcher, J]]		[[Category: Boettcher, J]]
		+	[[Category: Muellauer, B J]]
	[[Category: Weiss-Puxbaum, A]]		[[Category: Weiss-Puxbaum, A]]
		+	[[Category: Zoephel, A]]
		+	[[Category: Inhibitor]]
		+	[[Category: Oncoprotein]]
		+	[[Category: Pwwp domain]]

OCA: Protected "6g3t" [edit=sysop:move=sysop]

OCA — Wed, 04 Apr 2018 04:50:58 GMT

Protected "6g3t" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:50, 4 April 2018

OCA: New page: '''Unreleased structure''' The entry 6g3t is ON HOLD until Paper Publication Authors: Boettcher, J., Muellauer, B.J., Weiss-Puxbaum, A., Zoephel, A. Description: X-ray structure of NSD...

OCA — Wed, 04 Apr 2018 04:50:57 GMT

New page: '''Unreleased structure''' The entry 6g3t is ON HOLD until Paper Publication Authors: Boettcher, J., Muellauer, B.J., Weiss-Puxbaum, A., Zoephel, A. Description: X-ray structure of NSD...

New page

'''Unreleased structure'''

The entry 6g3t is ON HOLD until Paper Publication

Authors: Boettcher, J., Muellauer, B.J., Weiss-Puxbaum, A., Zoephel, A.

Description: X-ray structure of NSD3-PWWP1
[[Category: Unreleased Structures]]
[[Category: Muellauer, B.J]]
[[Category: Zoephel, A]]
[[Category: Boettcher, J]]
[[Category: Weiss-Puxbaum, A]]

6g3t - Revision history

OCA at 06:46, 26 June 2019

OCA: Protected "6g3t" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6g3t is ON HOLD until Paper Publication Authors: Boettcher, J., Muellauer, B.J., Weiss-Puxbaum, A., Zoephel, A. Description: X-ray structure of NSD...