OCA at 20:32, 2 December 2018

OCA — Sun, 02 Dec 2018 20:32:05 GMT

←Older revision		Revision as of 20:32, 2 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6g3y is ~~ON HOLD~~	+	==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH5675==
		+	<StructureSection load='6g3y' size='340' side='right' caption='[[6g3y]], [[Resolution\|resolution]] 2.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6g3y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G3Y FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ELB:4-(4-azanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide'>ELB</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ogg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g3y OCA], [http://pdbe.org/6g3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g3y RCSB], [http://www.ebi.ac.uk/pdbsum/6g3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g3y ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OGG1_MOUSE OGG1_MOUSE]] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflammation. We developed TH5487, a selective active-site inhibitor of OGG1, which hampers OGG1 binding to and repair of 8-oxoG and which is well tolerated by mice. TH5487 prevents tumor necrosis factor-alpha-induced OGG1-DNA interactions at guanine-rich promoters of proinflammatory genes. This, in turn, decreases DNA occupancy of nuclear factor kappaB and proinflammatory gene expression, resulting in decreased immune cell recruitment to mouse lungs. Thus, we present a proof of concept that targeting oxidative DNA repair can alleviate inflammatory conditions in vivo.

-	~~Authors~~:	+	Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.,Visnes T, Cazares-Korner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, Paulin CBJ, Pham T, Rasti A, Berglund UW, von Nicolai C, Benitez-Buelga C, Koolmeister T, Ivanic D, Iliev P, Scobie M, Krokan HE, Baranczewski P, Artursson P, Altun M, Jensen AJ, Kalderen C, Ba X, Zubarev RA, Stenmark P, Boldogh I, Helleday T Science. 2018 Nov 16;362(6416):834-839. doi: 10.1126/science.aar8048. PMID:30442810<ref>PMID:30442810</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6g3y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
		+	[[Category: Helleday, T]]
		+	[[Category: Masuyer, G]]
		+	[[Category: Stenmark, P]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna lyase]]
		+	[[Category: N-glycosylase]]

OCA: Protected "6g3y" [edit=sysop:move=sysop]

OCA — Wed, 04 Apr 2018 04:51:12 GMT

Protected "6g3y" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:51, 4 April 2018

OCA: New page: '''Unreleased structure''' The entry 6g3y is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Apr 2018 04:51:10 GMT

New page: '''Unreleased structure''' The entry 6g3y is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6g3y is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6g3y - Revision history

OCA at 20:32, 2 December 2018

OCA: Protected "6g3y" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6g3y is ON HOLD Authors: Description: Category: Unreleased Structures