6g5s - Revision history

OCA at 10:47, 14 June 2023

OCA — Wed, 14 Jun 2023 10:47:17 GMT

←Older revision		Revision as of 10:47, 14 June 2023
Line 1:		Line 1:

	==Solution structure of the TPR domain of the cell division coordinator, CpoB==		==Solution structure of the TPR domain of the cell division coordinator, CpoB==
-	<StructureSection load='6g5s' size='340' side='right'caption='[[6g5s~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6g5s' size='340' side='right'caption='[[6g5s]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g5s]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6G5S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G5S FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xev\|2xev]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5s OCA], [https://pdbe.org/6g5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g5s RCSB], [https://www.ebi.ac.uk/pdbsum/6g5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5s ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cpoB, ybgF, b0742, JW0732 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6g5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5s OCA], [~~http~~://pdbe.org/6g5s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6g5s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6g5s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5s ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CPOB_ECOLI CPOB_ECOLI]] Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division. Promotes physical and functional coordination of the PBP1B-LpoB and Tol machines, and regulates PBP1B activity in response to Tol energy state.<ref>PMID:25951518</ref>	+	[https://www.uniprot.org/uniprot/CPOB_ECOLI CPOB_ECOLI] Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division. Promotes physical and functional coordination of the PBP1B-LpoB and Tol machines, and regulates PBP1B activity in response to Tol energy state.<ref>PMID:25951518</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bougault, C]]	+	[[Category: Bougault C]]
-	[[Category: Egan, A]]	+	[[Category: Egan A]]
-	[[Category: Martinez~~, R C.Maya~~]]	+	[[Category: Maya Martinez RC]]
-	[[Category: Simorre~~, J P~~]]	+	[[Category: Simorre JP]]
-	[[Category: Vollmer, W]]	+	[[Category: Vollmer W]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division coordinator]]~~	+
-	~~[[Category: E. coli]]~~	+
-	~~[[Category: Pbp1b]]~~	+
-	~~[[Category: Transpeptidase regulator~~]]	+

OCA at 13:29, 10 May 2019

OCA — Fri, 10 May 2019 13:29:33 GMT

←Older revision		Revision as of 13:29, 10 May 2019
Line 1:		Line 1:

	==Solution structure of the TPR domain of the cell division coordinator, CpoB==		==Solution structure of the TPR domain of the cell division coordinator, CpoB==
-	<StructureSection load='6g5s' size='340' side='right' caption='[[6g5s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='6g5s' size='340' side='right'caption='[[6g5s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6g5s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G5S FirstGlance]. <br>		<table><tr><td colspan='2'>[[6g5s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G5S FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Bougault, C]]		[[Category: Bougault, C]]
	[[Category: Egan, A]]		[[Category: Egan, A]]

OCA at 12:48, 7 November 2018

OCA — Wed, 07 Nov 2018 12:48:38 GMT

←Older revision		Revision as of 12:48, 7 November 2018
Line 3:		Line 3:
	<StructureSection load='6g5s' size='340' side='right' caption='[[6g5s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6g5s' size='340' side='right' caption='[[6g5s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g5s]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G5S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g5s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G5S FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xev\|2xev]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xev\|2xev]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cpoB, ybgF, b0742, JW0732 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5s OCA], [http://pdbe.org/6g5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g5s RCSB], [http://www.ebi.ac.uk/pdbsum/6g5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5s OCA], [http://pdbe.org/6g5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g5s RCSB], [http://www.ebi.ac.uk/pdbsum/6g5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5s ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Bougault, C]]		[[Category: Bougault, C]]
	[[Category: Egan, A]]		[[Category: Egan, A]]

OCA at 21:55, 9 August 2018

OCA — Thu, 09 Aug 2018 21:55:09 GMT

←Older revision		Revision as of 21:55, 9 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6g5s is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Solution structure of the TPR domain of the cell division coordinator, CpoB==
		+	<StructureSection load='6g5s' size='340' side='right' caption='[[6g5s]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6g5s]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G5S FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xev\|2xev]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5s OCA], [http://pdbe.org/6g5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g5s RCSB], [http://www.ebi.ac.uk/pdbsum/6g5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5s ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CPOB_ECOLI CPOB_ECOLI]] Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division. Promotes physical and functional coordination of the PBP1B-LpoB and Tol machines, and regulates PBP1B activity in response to Tol energy state.<ref>PMID:25951518</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacteria surround their cytoplasmic membrane with an essential, stress-bearing peptidoglycan (PG) layer consisting of glycan chains linked by short peptides into a mesh-like structure. Growing and dividing cells expand their PG layer using inner-membrane anchored PG synthases, including Penicillin-binding proteins (PBPs), which participate in dynamic protein complexes to facilitate cell wall growth. In Escherichia coli, and presumably other Gram-negative bacteria, growth of the mainly single layered PG is regulated by outer membrane-anchored lipoproteins. The lipoprotein LpoB is required to activate PBP1B, which is a major, bi-functional PG synthase with glycan chain polymerizing (glycosyltransferase) and peptide cross-linking (transpeptidase) activities. In this work we show how the binding of LpoB to the regulatory UB2H domain of PBP1B activates both activities. Binding induces structural changes in the UB2H domain, which transduce to the two catalytic domains by distinct allosteric pathways. We also show how an additional regulator protein, CpoB, is able to selectively modulate the TPase activation by LpoB without interfering with GTase activation. This article is protected by copyright. All rights reserved.

-	~~Authors: Simorre, J.P~~., Maya Martinez, R~~.C.~~, Bougault, C., ~~Vollmer~~, W., ~~Egan, A~~.	+	Induced conformational changes activate the peptidoglycan synthase PBP1B.,Egan AJF, Maya-Martinez R, Ayala I, Bougault CM, Banzhaf M, Breukink E, Vollmer W, Simorre JP Mol Microbiol. 2018 Jul 25. doi: 10.1111/mmi.14082. PMID:30044025<ref>PMID:30044025</ref>

-	~~Description: Solution structure~~ of the ~~TPR domain~~ of ~~the cell division coordinator, CpoB~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6g5s" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bougault, C]]		[[Category: Bougault, C]]
-	[[Category: Vollmer, W]]
-	[[Category: Maya Martinez, R.C]]
	[[Category: Egan, A]]		[[Category: Egan, A]]
-	[[Category: Simorre, J.P]]	+	[[Category: Martinez, R C.Maya]]
		+	[[Category: Simorre, J P]]
		+	[[Category: Vollmer, W]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell division coordinator]]
		+	[[Category: E. coli]]
		+	[[Category: Pbp1b]]
		+	[[Category: Transpeptidase regulator]]

OCA: Protected "6g5s" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2018 12:38:21 GMT

Protected "6g5s" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:38, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 6g5s is ON HOLD until Paper Publication Authors: Simorre, J.P., Maya Martinez, R.C., Bougault, C., Vollmer, W., Egan, A. Description: Solution stru...

OCA — Wed, 11 Apr 2018 12:38:20 GMT

New page: '''Unreleased structure''' The entry 6g5s is ON HOLD until Paper Publication Authors: Simorre, J.P., Maya Martinez, R.C., Bougault, C., Vollmer, W., Egan, A. Description: Solution stru...

New page

'''Unreleased structure'''

The entry 6g5s is ON HOLD until Paper Publication

Authors: Simorre, J.P., Maya Martinez, R.C., Bougault, C., Vollmer, W., Egan, A.

Description: Solution structure of the TPR domain of the cell division coordinator, CpoB
[[Category: Unreleased Structures]]
[[Category: Bougault, C]]
[[Category: Vollmer, W]]
[[Category: Maya Martinez, R.C]]
[[Category: Egan, A]]
[[Category: Simorre, J.P]]