6g6i - Revision history

OCA at 07:53, 24 April 2019

OCA — Wed, 24 Apr 2019 07:53:47 GMT

←Older revision		Revision as of 07:53, 24 April 2019
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	==MamM CTD W247A==		==MamM CTD W247A==
-	<StructureSection load='6g6i' size='340' side='right' caption='[[6g6i]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='6g6i' size='340' side='right'caption='[[6g6i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g6i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G6I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g6i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_6361 Dsm 6361]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G6I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mamM, mgI491, MGR_4095 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=55518 DSM 6361])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6i OCA], [http://pdbe.org/6g6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g6i RCSB], [http://www.ebi.ac.uk/pdbsum/6g6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6i OCA], [http://pdbe.org/6g6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g6i RCSB], [http://www.ebi.ac.uk/pdbsum/6g6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6i ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cation diffusion facilitator (CDF) proteins are a conserved family of transmembrane transporters that ensure cellular homeostasis of divalent transition metal cations. Metal cations bind to CDF protein's cytoplasmic C-terminal domain (CTD), leading to closure from its apo open V-shaped dimer to a tighter packed structure, followed by a conformational change of the transmembrane domain, thus enabling transport of the metal cation. By implementing a comprehensive range of biochemical and biophysical methods, we studied the molecular mechanism of metal binding to the magnetotactic bacterial CDF protein MamM CTD. Our results reveal that the CTD is rather dynamic in its apo form, and that two dependent metal-binding sites, a single central binding site and two symmetrical, peripheral sites, are available for metal binding. However, only cation binding to the peripheral sites leads to conformational changes that lock the protein in a compact state. Thus, this work reveals how metal binding is regulating the sequential uptakes of metal cations by MamM, and extends our understanding of the complex regulation mechanism of CDF proteins. DATABASE: Structural data are available in RCSB Protein Data Bank under the accession numbers: 6G64, 6G55, 6G5E and 6G6I (for CS, C267S, CS-C267S and W247A, respectively).
		+
		+	Metal binding to the dynamic cytoplasmic domain of the cation diffusion facilitator (CDF) protein MamM induces a 'locked-in' configuration.,Barber-Zucker S, Hall J, Mangapuram SV, Kass I, Kolusheva S, MacMillan F, Zarivach R, Henn A FEBS J. 2019 Feb 27. doi: 10.1111/febs.14795. PMID:30811856<ref>PMID:30811856</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6g6i" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dsm 6361]]
		+	[[Category: Large Structures]]
	[[Category: Barber-Zucker, S]]		[[Category: Barber-Zucker, S]]
	[[Category: Zarivach, R]]		[[Category: Zarivach, R]]

OCA at 06:56, 31 October 2018

OCA — Wed, 31 Oct 2018 06:56:48 GMT

←Older revision		Revision as of 06:56, 31 October 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6g6i is ~~ON HOLD until Oct 01 2019~~	+	==MamM CTD W247A==
-		+	<StructureSection load='6g6i' size='340' side='right' caption='[[6g6i]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6g6i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G6I FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6i OCA], [http://pdbe.org/6g6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g6i RCSB], [http://www.ebi.ac.uk/pdbsum/6g6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6i ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Barber-Zucker, S]]
		+	[[Category: Zarivach, R]]
		+	[[Category: Cation diffusion facilitator]]
		+	[[Category: Magnetotactic bacteria]]
		+	[[Category: Metal transport]]

OCA at 04:25, 18 April 2018

OCA — Wed, 18 Apr 2018 04:25:13 GMT

←Older revision		Revision as of 04:25, 18 April 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6g6i is ON HOLD	+	The entry 6g6i is ON HOLD until Oct 01 2019

	Authors:		Authors:

OCA: Protected "6g6i" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2018 12:39:53 GMT

Protected "6g6i" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:39, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 6g6i is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Apr 2018 12:39:52 GMT

New page: '''Unreleased structure''' The entry 6g6i is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6g6i is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]