6g70 - Revision history

OCA at 12:34, 9 May 2024

OCA — Thu, 09 May 2024 12:34:09 GMT

←Older revision		Revision as of 12:34, 9 May 2024
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	<StructureSection load='6g70' size='340' side='right'caption='[[6g70]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6g70' size='340' side='right'caption='[[6g70]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g70]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G70 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6G70 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G70 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Prpf39 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g70 OCA], [~~http~~://pdbe.org/6g70 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6g70 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6g70 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6g70 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g70 OCA], [https://pdbe.org/6g70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g70 RCSB], [https://www.ebi.ac.uk/pdbsum/6g70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g70 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PRP39_MOUSE PRP39_MOUSE] Involved in pre-mRNA splicing.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Bortoli~~, F D.De~~]]	+	[[Category: De Bortoli FD]]
-	[[Category: Heyd, F]]	+	[[Category: Heyd F]]
-	[[Category: Loll, B]]	+	[[Category: Loll B]]
-	[[Category: Wahl, M]]	+	[[Category: Wahl M]]
-	~~[[Category: Hat repeat protein]]~~	+
-	~~[[Category: Splicing]]~~	+
-	~~[[Category: U1snrnp~~]]	+

OCA at 05:58, 22 April 2020

OCA — Wed, 22 Apr 2020 05:58:29 GMT

←Older revision		Revision as of 05:58, 22 April 2020
Line 3:		Line 3:
	<StructureSection load='6g70' size='340' side='right'caption='[[6g70]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6g70' size='340' side='right'caption='[[6g70]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g70]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G70 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6G70 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g70]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G70 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6G70 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prpf39 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prpf39 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g70 OCA], [http://pdbe.org/6g70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g70 RCSB], [http://www.ebi.ac.uk/pdbsum/6g70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g70 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g70 OCA], [http://pdbe.org/6g70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g70 RCSB], [http://www.ebi.ac.uk/pdbsum/6g70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g70 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:49, 17 April 2019

OCA — Wed, 17 Apr 2019 06:49:10 GMT

←Older revision		Revision as of 06:49, 17 April 2019
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	<StructureSection load='6g70' size='340' side='right'caption='[[6g70]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6g70' size='340' side='right'caption='[[6g70]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g70]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G70 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g70]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G70 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g70 OCA], [http://pdbe.org/6g70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g70 RCSB], [http://www.ebi.ac.uk/pdbsum/6g70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g70 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Prpf39 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g70 OCA], [http://pdbe.org/6g70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g70 RCSB], [http://www.ebi.ac.uk/pdbsum/6g70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g70 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the yeast U1 snRNP the Prp39/Prp42 heterodimer is essential for early steps of spliceosome assembly. In metazoans no Prp42 ortholog exists, raising the question how the heterodimer is functionally substituted. Here we present the crystal structure of murine PRPF39, which forms a homodimer. Structure-guided point mutations disrupt dimer formation and inhibit splicing, manifesting the homodimer as functional unit. PRPF39 expression is controlled by NMD-inducing alternative splicing in mice and human, suggesting a role in adapting splicing efficiency to cell type specific requirements. A phylogenetic analysis reveals coevolution of shortened U1 snRNA and the absence of Prp42, which correlates with overall splicing complexity in different fungi. While current models correlate the diversity of spliceosomal proteins with splicing complexity, our study highlights a contrary case. We find that organisms with higher splicing complexity have substituted the Prp39/Prp42 heterodimer with a PRPF39 homodimer.
		+
		+	Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.,De Bortoli F, Neumann A, Kotte A, Timmermann B, Schuler T, Wahl MC, Loll B, Heyd F Nucleic Acids Res. 2019 Apr 5. pii: 5428331. doi: 10.1093/nar/gkz243. PMID:30949712<ref>PMID:30949712</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6g70" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Bortoli, F D.De]]		[[Category: Bortoli, F D.De]]
	[[Category: Heyd, F]]		[[Category: Heyd, F]]

OCA at 06:55, 3 April 2019

OCA — Wed, 03 Apr 2019 06:55:12 GMT

←Older revision		Revision as of 06:55, 3 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6g70 is ~~ON HOLD until Apr 04 2020~~	+	==Structure of murine Prpf39==
-		+	<StructureSection load='6g70' size='340' side='right'caption='[[6g70]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6g70]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G70 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g70 OCA], [http://pdbe.org/6g70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g70 RCSB], [http://www.ebi.ac.uk/pdbsum/6g70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g70 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bortoli, F D.De]]
		+	[[Category: Heyd, F]]
		+	[[Category: Loll, B]]
		+	[[Category: Wahl, M]]
		+	[[Category: Hat repeat protein]]
		+	[[Category: Splicing]]
		+	[[Category: U1snrnp]]

OCA at 04:16, 25 April 2018

OCA — Wed, 25 Apr 2018 04:16:53 GMT

←Older revision		Revision as of 04:16, 25 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6g70 is ON HOLD	+	The entry 6g70 is ON HOLD until Apr 04 2020

	Authors:		Authors:

OCA: Protected "6g70" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2018 12:41:24 GMT

Protected "6g70" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:41, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 6g70 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Apr 2018 12:41:22 GMT

New page: '''Unreleased structure''' The entry 6g70 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6g70 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]