OCA at 12:34, 9 May 2024

OCA — Thu, 09 May 2024 12:34:11 GMT

←Older revision		Revision as of 12:34, 9 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 6g7b is ~~ON HOLD~~	+	==Nt2 domain of the TssA component from the type VI secretion system of Aeromonas hydrophila.==
		+	<StructureSection load='6g7b' size='340' side='right'caption='[[6g7b]], [[Resolution\|resolution]] 1.76Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6g7b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeromonas_hydrophila_subsp._hydrophila_ATCC_7966 Aeromonas hydrophila subsp. hydrophila ATCC 7966]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G7B FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.76Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g7b OCA], [https://pdbe.org/6g7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g7b RCSB], [https://www.ebi.ac.uk/pdbsum/6g7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g7b ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0KJC7_AERHH A0KJC7_AERHH]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The type VI secretion system (T6SS) is a multi-protein complex that injects bacterial effector proteins into target cells. It is composed of a cell membrane complex anchored to a contractile bacteriophage tail-like apparatus consisting of a sharpened tube that is ejected by the contraction of a sheath against a baseplate. We present structural and biochemical studies on TssA subunits from two different T6SSs that reveal radically different quaternary structures in comparison to the dodecameric E. coli TssA that arise from differences in their C-terminal sequences. Despite this, the different TssAs retain equivalent interactions with other components of the complex and position their highly conserved N-terminal ImpA_N domain at the same radius from the centre of the sheath as a result of their distinct domain architectures, which includes additional spacer domains and highly mobile interdomain linkers. Together, these variations allow these distinct TssAs to perform a similar function in the complex.

-	~~Authors~~:	+	Structural insights into the function of type VI secretion system TssA subunits.,Dix SR, Owen HJ, Sun R, Ahmad A, Shastri S, Spiewak HL, Mosby DJ, Harris MJ, Batters SL, Brooker TA, Tzokov SB, Sedelnikova SE, Baker PJ, Bullough PA, Rice DW, Thomas MS Nat Commun. 2018 Nov 12;9(1):4765. doi: 10.1038/s41467-018-07247-1. PMID:30420757<ref>PMID:30420757</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6g7b" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aeromonas hydrophila subsp. hydrophila ATCC 7966]]
		+	[[Category: Large Structures]]
		+	[[Category: Ahmad A]]
		+	[[Category: Baker PJ]]
		+	[[Category: Batters SL]]
		+	[[Category: Bullough PA]]
		+	[[Category: Dix SD]]
		+	[[Category: Harris MJ]]
		+	[[Category: Mosby DJ]]
		+	[[Category: Owen HJ]]
		+	[[Category: Rice DW]]
		+	[[Category: Sedelnikova SE]]
		+	[[Category: Shastri S]]
		+	[[Category: Spiewak HL]]
		+	[[Category: Sun R]]
		+	[[Category: Thomas MS]]
		+	[[Category: Tzokov SB]]

OCA: Protected "6g7b" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2018 12:42:12 GMT

Protected "6g7b" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:42, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 6g7b is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Apr 2018 12:42:11 GMT

New page: '''Unreleased structure''' The entry 6g7b is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6g7b is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6g7b - Revision history

OCA at 12:34, 9 May 2024

OCA: Protected "6g7b" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6g7b is ON HOLD Authors: Description: Category: Unreleased Structures