6g8s - Revision history

OCA at 12:34, 9 May 2024

OCA — Thu, 09 May 2024 12:34:49 GMT

←Older revision		Revision as of 12:34, 9 May 2024
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	<StructureSection load='6g8s' size='340' side='right'caption='[[6g8s]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='6g8s' size='340' side='right'caption='[[6g8s]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6g8s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G8S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6G8S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6g8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G8S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=EQQ:Ruthenium+(bis-(tetraazaphenanthrene))+(11,12-dicyano-dipyridophenazine)'>EQQ</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.66Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6g8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g8s OCA], [~~http~~://pdbe.org/6g8s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6g8s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6g8s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6g8s ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=EQQ:Ruthenium+(bis-(tetraazaphenanthrene))+(11,12-dicyano-dipyridophenazine)'>EQQ</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g8s OCA], [https://pdbe.org/6g8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g8s RCSB], [https://www.ebi.ac.uk/pdbsum/6g8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g8s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cardin, C J~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Hall, J P~~]]	+	[[Category: Cardin CJ]]
-	[[Category: ~~McQuaid, K T~~]]	+	[[Category: Hall JP]]
-	[[Category: ~~Asymmetric]]~~	+	[[Category: McQuaid KT]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Intercalation]]~~	+
-	~~[[Category: Ruthenium~~]]	+

OCA at 15:53, 28 August 2019

OCA — Wed, 28 Aug 2019 15:53:59 GMT

←Older revision		Revision as of 15:53, 28 August 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g8s OCA], [http://pdbe.org/6g8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g8s RCSB], [http://www.ebi.ac.uk/pdbsum/6g8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g8s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g8s OCA], [http://pdbe.org/6g8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g8s RCSB], [http://www.ebi.ac.uk/pdbsum/6g8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g8s ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The new complexes [Ru(TAP)2 (11-CN-dppz)](2+) , [Ru(TAP)2 (11-Br-dppz)](2+) and [Ru(TAP)2 (11,12-diCN-dppz)](2+) are reported. The addition of nitrile substituents to the dppz ligand of the DNA photo-oxidising complex [Ru(TAP)2 (dppz)](2+) promote pi-stacking interactions and ordered binding to DNA, as shown by X-ray crystallography. The structure of Lambda-[Ru(TAP)2 (11-CN-dppz)](2+) with the DNA duplex d(TCGGCGCCGA)2 shows, for the first time with this class of complex, a closed intercalation cavity with an AT base pair at the terminus. The structure obtained is compared to that formed with the 11-Br and 11,12-dinitrile derivatives, highlighting the stabilization of syn guanine by this enantiomer when the terminal base pair is GC. In contrast the AT base pair has the normal Watson-Crick orientation, highlighting the difference in charge distribution between the two purine bases and the complementarity of the dppz-purine interaction. The asymmetry of the cavity highlights the importance of the purine-dppz-purine stacking interaction.
		+
		+	X-ray Crystal Structures Show DNA Stacking Advantage of Terminal Nitrile Substitution in Ru-dppz Complexes.,McQuaid K, Hall JP, Brazier JA, Cardin DJ, Cardin CJ Chemistry. 2018 Oct 22;24(59):15859-15867. doi: 10.1002/chem.201803021. Epub 2018, Oct 1. PMID:30063271<ref>PMID:30063271</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6g8s" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:41, 24 April 2019

OCA — Wed, 24 Apr 2019 06:41:21 GMT

←Older revision		Revision as of 06:41, 24 April 2019
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-	'''Unreleased structure'''

-	~~The entry 6g8s is ON HOLD~~	+	==[Ru(TAP)2(11,12-CN2-dppz)]2+ bound to d(CCGGACCCGG/CCGGGTCCGG)2==
-		+	<StructureSection load='6g8s' size='340' side='right'caption='[[6g8s]], [[Resolution\|resolution]] 1.66Å' scene=''>
-	~~Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6g8s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G8S FirstGlance]. <br>
-	~~Description:~~ [Ru(TAP)2(11,12-CN2-dppz)]2+ bound to d(CCGGACCCGG/CCGGGTCCGG)2	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=EQQ:Ruthenium+(bis-(tetraazaphenanthrene))+(11,12-dicyano-dipyridophenazine)'>EQQ</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g8s OCA], [http://pdbe.org/6g8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g8s RCSB], [http://www.ebi.ac.uk/pdbsum/6g8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g8s ProSAT]</span></td></tr>
-	[[Category: ~~Hall~~, J.P]]	+	</table>
-	[[Category: ~~Cardin~~, C.J]]	+	__TOC__
-	[[Category: ~~Mcquaid~~, K.T]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cardin, C J]]
		+	[[Category: Hall, J P]]
		+	[[Category: McQuaid, K T]]
		+	[[Category: Asymmetric]]
		+	[[Category: Dna]]
		+	[[Category: Intercalation]]
		+	[[Category: Ruthenium]]

OCA: Protected "6g8s" [edit=sysop:move=sysop]

OCA — Wed, 18 Apr 2018 04:28:46 GMT

Protected "6g8s" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:28, 18 April 2018

OCA: New page: '''Unreleased structure''' The entry 6g8s is ON HOLD Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J. Description: [Ru(TAP)2(11,12-CN2-dppz)]2+ bound to d(CCGGACCCGG/CCGGGTCCGG)2 [[Cat...

OCA — Wed, 18 Apr 2018 04:28:45 GMT

New page: '''Unreleased structure''' The entry 6g8s is ON HOLD Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J. Description: [Ru(TAP)2(11,12-CN2-dppz)]2+ bound to d(CCGGACCCGG/CCGGGTCCGG)2 [[Cat...

New page

'''Unreleased structure'''

The entry 6g8s is ON HOLD

Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J.

Description: [Ru(TAP)2(11,12-CN2-dppz)]2+ bound to d(CCGGACCCGG/CCGGGTCCGG)2
[[Category: Unreleased Structures]]
[[Category: Hall, J.P]]
[[Category: Cardin, C.J]]
[[Category: Mcquaid, K.T]]