6gii - Revision history

OCA at 08:18, 14 June 2018

OCA — Thu, 14 Jun 2018 08:18:19 GMT

←Older revision		Revision as of 08:18, 14 June 2018
Line 3:		Line 3:
	<StructureSection load='6gii' size='340' side='right' caption='[[6gii]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6gii' size='340' side='right' caption='[[6gii]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gii]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GII FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gii]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_2722 Dsm 2722]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GII FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ga0061068_103196 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=876478 DSM 2722])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gii OCA], [http://pdbe.org/6gii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gii RCSB], [http://www.ebi.ac.uk/pdbsum/6gii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gii ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gii OCA], [http://pdbe.org/6gii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gii RCSB], [http://www.ebi.ac.uk/pdbsum/6gii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gii ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dsm 2722]]
	[[Category: Levy, C W]]		[[Category: Levy, C W]]
	[[Category: Cytochrome p450 class vii]]		[[Category: Cytochrome p450 class vii]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 05:40, 30 May 2018

OCA — Wed, 30 May 2018 05:40:58 GMT

←Older revision		Revision as of 05:40, 30 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 6gii is ~~ON HOLD~~	+	==The crystal structure of Tepidiphilus thermophilus P450 heme domain==
		+	<StructureSection load='6gii' size='340' side='right' caption='[[6gii]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6gii]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GII FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gii OCA], [http://pdbe.org/6gii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gii RCSB], [http://www.ebi.ac.uk/pdbsum/6gii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gii ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The first crystal structure of a class VII P450, CYP116B46 from Tepidiphilus thermophilus, has been solved at 1.9A resolution. The structure reveals overall conservation of the P450-fold and a water conduit around the I-helix. Active site residues have been identified and sequence comparisons have been made with other class VII enzymes. A structure similarity search demonstrated that the P450-TT structure is similar to enzymes capable of oxy-functionalization of fatty acids, terpenes, macrolides, steroids and statins. The insight gained from solving this structure will provide a guideline for future engineering and modelling studies on this catalytically promiscuous class of enzymes.

-	~~Authors:~~ Levy, C.W.	+	The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s.,Tavanti M, Porter JL, Levy CW, Gomez Castellanos JR, Flitsch SL, Turner NJ Biochem Biophys Res Commun. 2018 May 17. pii: S0006-291X(18)31059-3. doi:, 10.1016/j.bbrc.2018.05.014. PMID:29738765<ref>PMID:29738765</ref>

-	~~Description: The crystal structure~~ of ~~Tepidiphilus thermophilus P450 heme domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Levy, C.W~~]]	+	<div class="pdbe-citations 6gii" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Levy, C W]]
		+	[[Category: Cytochrome p450 class vii]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "6gii" [edit=sysop:move=sysop]

OCA — Wed, 16 May 2018 04:17:34 GMT

Protected "6gii" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:17, 16 May 2018

OCA: New page: '''Unreleased structure''' The entry 6gii is ON HOLD Authors: Levy, C.W. Description: The crystal structure of Tepidiphilus thermophilus P450 heme domain [[Category: Unreleased Structu...

OCA — Wed, 16 May 2018 04:17:32 GMT

New page: '''Unreleased structure''' The entry 6gii is ON HOLD Authors: Levy, C.W. Description: The crystal structure of Tepidiphilus thermophilus P450 heme domain [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 6gii is ON HOLD

Authors: Levy, C.W.

Description: The crystal structure of Tepidiphilus thermophilus P450 heme domain
[[Category: Unreleased Structures]]
[[Category: Levy, C.W]]