OCA at 22:43, 5 June 2019

OCA — Wed, 05 Jun 2019 22:43:29 GMT

←Older revision		Revision as of 22:43, 5 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6gku is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 6F5==
		+	<StructureSection load='6gku' size='340' side='right'caption='[[6gku]], [[Resolution\|resolution]] 1.91Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6gku]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GKU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6gks\|6gks]], [[6gkq\|6gkq]], [[6gkt\|6gkt]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gku OCA], [http://pdbe.org/6gku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gku RCSB], [http://www.ebi.ac.uk/pdbsum/6gku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gku ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG10_HUMAN LEG10_HUMAN]] Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).<ref>PMID:17502455</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although spontaneous protein crystallization is a rare event in vivo, Charcot-Leyden crystals (CLCs) consisting of galectin-10 (Gal10) protein are frequently observed in eosinophilic diseases, such as asthma. We found that CLCs derived from patients showed crystal packing and Gal10 structure identical to those of Gal10 crystals grown in vitro. When administered to the airways, crystalline Gal10 stimulated innate and adaptive immunity and acted as a type 2 adjuvant. By contrast, a soluble Gal10 mutein was inert. Antibodies directed against key epitopes of the CLC crystallization interface dissolved preexisting CLCs in patient-derived mucus within hours and reversed crystal-driven inflammation, goblet-cell metaplasia, immunoglobulin E (IgE) synthesis, and bronchial hyperreactivity (BHR) in a humanized mouse model of asthma. Thus, protein crystals may promote hallmark features of asthma and are targetable by crystal-dissolving antibodies.

-	~~Authors~~:	+	Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.,Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Goncalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN Science. 2019 May 24;364(6442). pii: 364/6442/eaaw4295. doi:, 10.1126/science.aaw4295. PMID:31123109<ref>PMID:31123109</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6gku" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Savvides, S N]]
		+	[[Category: Verschueren, K]]
		+	[[Category: Verstraete, K]]
		+	[[Category: Galectin-10]]
		+	[[Category: Mutant]]
		+	[[Category: Non-autocrystallizing]]
		+	[[Category: Sugar binding protein]]

OCA at 03:54, 17 April 2019

OCA — Wed, 17 Apr 2019 03:54:10 GMT

←Older revision		Revision as of 03:54, 17 April 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6gku is ON HOLD	+	The entry 6gku is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6gku" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2018 04:17:44 GMT

Protected "6gku" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:17, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 6gku is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 30 May 2018 04:17:43 GMT

New page: '''Unreleased structure''' The entry 6gku is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6gku is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6gku - Revision history

OCA at 22:43, 5 June 2019

OCA at 03:54, 17 April 2019

OCA: Protected "6gku" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6gku is ON HOLD Authors: Description: Category: Unreleased Structures