6glj - Revision history

OCA at 06:42, 21 February 2019

OCA — Thu, 21 Feb 2019 06:42:42 GMT

←Older revision		Revision as of 06:42, 21 February 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6glj is ON HOLD until Paper Publication~~	+	==Crystal structure of hMTH1 F27A in complex with TH scaffold 1 in the absence of acetate==
-		+	<StructureSection load='6glj' size='340' side='right' caption='[[6glj]], [[Resolution\|resolution]] 1.30Å' scene=''>
-	~~Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6glj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GLJ FirstGlance]. <br>
-	~~Description:~~ Crystal structure of hMTH1 F27A in complex with TH scaffold 1 in the absence of acetate	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F3E:4-phenylpyrimidin-2-amine'>F3E</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6glj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6glj OCA], [http://pdbe.org/6glj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6glj RCSB], [http://www.ebi.ac.uk/pdbsum/6glj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6glj ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Eberle~~, S.A]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Caflisch, A]]		[[Category: Caflisch, A]]
		+	[[Category: Eberle, S A]]
	[[Category: Sledz, P]]		[[Category: Sledz, P]]
	[[Category: Wiedmer, L]]		[[Category: Wiedmer, L]]
		+	[[Category: Complex]]
		+	[[Category: Dna repair]]
		+	[[Category: Fragment]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]

OCA at 05:50, 14 June 2018

OCA — Thu, 14 Jun 2018 05:50:56 GMT

←Older revision		Revision as of 05:50, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6glj is ON HOLD	+	The entry 6glj is ON HOLD until Paper Publication

	Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A.		Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A.

-	Description: hMTH1 F27A in complex with TH scaffold 1.	+	Description: Crystal structure of hMTH1 F27A in complex with TH scaffold 1 in the absence of acetate
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Eberle, S.A]]
	[[Category: Caflisch, A]]		[[Category: Caflisch, A]]
-	[[Category: Wiedmer, L]]
	[[Category: Sledz, P]]		[[Category: Sledz, P]]
-	[[Category: ~~Eberle~~, ~~S.A~~]]	+	[[Category: Wiedmer, L]]

OCA: Protected "6glj" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2018 04:21:06 GMT

Protected "6glj" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:21, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 6glj is ON HOLD Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A. Description: hMTH1 F27A in complex with TH scaffold 1. [[Category: Unre...

OCA — Wed, 30 May 2018 04:21:05 GMT

New page: '''Unreleased structure''' The entry 6glj is ON HOLD Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A. Description: hMTH1 F27A in complex with TH scaffold 1. [[Category: Unre...

New page

'''Unreleased structure'''

The entry 6glj is ON HOLD

Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A.

Description: hMTH1 F27A in complex with TH scaffold 1.
[[Category: Unreleased Structures]]
[[Category: Caflisch, A]]
[[Category: Wiedmer, L]]
[[Category: Sledz, P]]
[[Category: Eberle, S.A]]