6gnq - Revision history

OCA at 05:31, 12 June 2019

OCA — Wed, 12 Jun 2019 05:31:40 GMT

←Older revision		Revision as of 05:31, 12 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6gnq ~~is ON HOLD until Paper Publication~~	+	==Monoclinic crystalline form of human insulin, complexed with meta-cresol==
-		+	<StructureSection load='6gnq' size='340' side='right'caption='[[6gnq]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~: ~~Margiolaki, I~~.~~, Karavassili, F~~.~~, Valmas, A~~., ~~Dimarogona~~, M., ~~Giannopoulou~~, A.E., ~~Fili, S~~., ~~Schluckebier, G~~., ~~Norrman, M~~., ~~Beckers, D~~., ~~Fitch, A~~.N.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6gnq]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GNQ FirstGlance]. <br>
-	~~Description~~: ~~Monoclinic crystalline form~~ of ~~human~~ insulin, ~~complexed with meta~~-~~cresol~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IS8:isothiocyanate'>IS8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gnq OCA], [http://pdbe.org/6gnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gnq RCSB], [http://www.ebi.ac.uk/pdbsum/6gnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gnq ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Karavassili~~, F]]	+	</table>
-	[[Category: ~~Norrman, M~~]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[http://omim.org/entry/176730 176730]].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[http://omim.org/entry/125852 125852]]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[http://omim.org/entry/606176 606176]]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[http://omim.org/entry/613370 613370]]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Beckers, D]]		[[Category: Beckers, D]]
		+	[[Category: Dimarogona, M]]
	[[Category: Fili, S]]		[[Category: Fili, S]]
-	[[Category: ~~Valmas~~, A]]	+	[[Category: Fitch, A N]]
-	[[Category: Giannopoulou, A.E]]	+	[[Category: Giannopoulou, A E]]
-	[[Category: ~~Fitch, A.N]]~~	+	[[Category: Karavassili, F]]
-	~~[[Category: Dimarogona~~, M]]	+
	[[Category: Margiolaki, I]]		[[Category: Margiolaki, I]]
		+	[[Category: Norrman, M]]
	[[Category: Schluckebier, G]]		[[Category: Schluckebier, G]]
		+	[[Category: Valmas, A]]
		+	[[Category: Complex]]
		+	[[Category: Hexamer]]
		+	[[Category: Hormone]]
		+	[[Category: Human insulin]]
		+	[[Category: Meta-cresol]]

OCA at 05:52, 14 June 2018

OCA — Thu, 14 Jun 2018 05:52:36 GMT

←Older revision		Revision as of 05:52, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6gnq is ON HOLD	+	The entry 6gnq is ON HOLD until Paper Publication

	Authors: Margiolaki, I., Karavassili, F., Valmas, A., Dimarogona, M., Giannopoulou, A.E., Fili, S., Schluckebier, G., Norrman, M., Beckers, D., Fitch, A.N.		Authors: Margiolaki, I., Karavassili, F., Valmas, A., Dimarogona, M., Giannopoulou, A.E., Fili, S., Schluckebier, G., Norrman, M., Beckers, D., Fitch, A.N.
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	Description: Monoclinic crystalline form of human insulin, complexed with meta-cresol		Description: Monoclinic crystalline form of human insulin, complexed with meta-cresol
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Valmas, A]]
-	[[Category: Giannopoulou, A.E]]
-	[[Category: Dimarogona, M]]
-	[[Category: Schluckebier, G]]
	[[Category: Karavassili, F]]		[[Category: Karavassili, F]]
	[[Category: Norrman, M]]		[[Category: Norrman, M]]
	[[Category: Beckers, D]]		[[Category: Beckers, D]]
	[[Category: Fili, S]]		[[Category: Fili, S]]
		+	[[Category: Valmas, A]]
		+	[[Category: Giannopoulou, A.E]]
	[[Category: Fitch, A.N]]		[[Category: Fitch, A.N]]
		+	[[Category: Dimarogona, M]]
	[[Category: Margiolaki, I]]		[[Category: Margiolaki, I]]
		+	[[Category: Schluckebier, G]]

OCA: Protected "6gnq" [edit=sysop:move=sysop]

OCA — Wed, 06 Jun 2018 04:32:47 GMT

Protected "6gnq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:32, 6 June 2018

OCA: New page: '''Unreleased structure''' The entry 6gnq is ON HOLD Authors: Margiolaki, I., Karavassili, F., Valmas, A., Dimarogona, M., Giannopoulou, A.E., Fili, S., Schluckebier, G., Norrman, M., B...

OCA — Wed, 06 Jun 2018 04:32:46 GMT

New page: '''Unreleased structure''' The entry 6gnq is ON HOLD Authors: Margiolaki, I., Karavassili, F., Valmas, A., Dimarogona, M., Giannopoulou, A.E., Fili, S., Schluckebier, G., Norrman, M., B...

New page

'''Unreleased structure'''

The entry 6gnq is ON HOLD

Authors: Margiolaki, I., Karavassili, F., Valmas, A., Dimarogona, M., Giannopoulou, A.E., Fili, S., Schluckebier, G., Norrman, M., Beckers, D., Fitch, A.N.

Description: Monoclinic crystalline form of human insulin, complexed with meta-cresol
[[Category: Unreleased Structures]]
[[Category: Valmas, A]]
[[Category: Giannopoulou, A.E]]
[[Category: Dimarogona, M]]
[[Category: Schluckebier, G]]
[[Category: Karavassili, F]]
[[Category: Norrman, M]]
[[Category: Beckers, D]]
[[Category: Fili, S]]
[[Category: Fitch, A.N]]
[[Category: Margiolaki, I]]