6gqe - Revision history

OCA at 23:02, 5 June 2019

OCA — Wed, 05 Jun 2019 23:02:35 GMT

←Older revision		Revision as of 23:02, 5 June 2019
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	<StructureSection load='6gqe' size='340' side='right'caption='[[6gqe]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='6gqe' size='340' side='right'caption='[[6gqe]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GQE FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2BP3, IMP3, KOC1, VICKZ3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~9823 PIG~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2BP3, IMP3, KOC1, VICKZ3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gqe OCA], [http://pdbe.org/6gqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gqe RCSB], [http://www.ebi.ac.uk/pdbsum/6gqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gqe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gqe OCA], [http://pdbe.org/6gqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gqe RCSB], [http://www.ebi.ac.uk/pdbsum/6gqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/IF2B3_HUMAN IF2B3_HUMAN]] RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.<ref>PMID:16541107</ref> <ref>PMID:23640942</ref>		[[http://www.uniprot.org/uniprot/IF2B3_HUMAN IF2B3_HUMAN]] RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.<ref>PMID:16541107</ref> <ref>PMID:23640942</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	How multidomain RNA-binding proteins recognize their specific target sequences, based on a combinatorial code, represents a fundamental unsolved question and has not been studied systematically so far. Here we focus on a prototypical multidomain RNA-binding protein, IMP3 (also called IGF2BP3), which contains six RNA-binding domains (RBDs): four KH and two RRM domains. We establish an integrative systematic strategy, combining single-domain-resolved SELEX-seq, motif-spacing analyses, in vivo iCLIP, functional validation assays, and structural biology. This approach identifies the RNA-binding specificity and RNP topology of IMP3, involving all six RBDs and a cluster of up to five distinct and appropriately spaced CA-rich and GGC-core RNA elements, covering a >100 nucleotide-long target RNA region. Our generally applicable approach explains both specificity and flexibility of IMP3-RNA recognition, allows the prediction of IMP3 targets, and provides a paradigm for the function of multivalent interactions with multidomain RNA-binding proteins in gene regulation.
		+
		+	Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.,Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Muller S, Schreiner S, Friedhoff P, Huttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A Nat Commun. 2019 May 22;10(1):2266. doi: 10.1038/s41467-019-09769-8. PMID:31118463<ref>PMID:31118463</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6gqe" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pig]]
	[[Category: Janowski, R]]		[[Category: Janowski, R]]
	[[Category: Niessing, D]]		[[Category: Niessing, D]]

OCA at 07:30, 23 May 2019

OCA — Thu, 23 May 2019 07:30:51 GMT

←Older revision		Revision as of 07:30, 23 May 2019
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	<StructureSection load='6gqe' size='340' side='right'caption='[[6gqe]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='6gqe' size='340' side='right'caption='[[6gqe]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gqe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GQE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gqe OCA], [http://pdbe.org/6gqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gqe RCSB], [http://www.ebi.ac.uk/pdbsum/6gqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gqe ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2BP3, IMP3, KOC1, VICKZ3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gqe OCA], [http://pdbe.org/6gqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gqe RCSB], [http://www.ebi.ac.uk/pdbsum/6gqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gqe ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IF2B3_HUMAN IF2B3_HUMAN]] RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.<ref>PMID:16541107</ref> <ref>PMID:23640942</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Pig]]
	[[Category: Janowski, R]]		[[Category: Janowski, R]]
	[[Category: Niessing, D]]		[[Category: Niessing, D]]

OCA at 06:46, 24 April 2019

OCA — Wed, 24 Apr 2019 06:46:56 GMT

←Older revision		Revision as of 06:46, 24 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6gqe ~~is ON HOLD until Paper Publication~~	+	==X-ray structure of KH1-2 domain of IMP3==
-		+	<StructureSection load='6gqe' size='340' side='right'caption='[[6gqe]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~Authors~~: ~~Janowski~~, R., ~~Schlundt, A~~., ~~Sattler~~, M., ~~Niessing, D~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6gqe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GQE FirstGlance]. <br>
-	~~Description: X-ray structure of KH1-2 domain of IMP3~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gqe OCA], [http://pdbe.org/6gqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gqe RCSB], [http://www.ebi.ac.uk/pdbsum/6gqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gqe ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Janowski, R]]		[[Category: Janowski, R]]
-	[[Category: Schlundt, A]]
	[[Category: Niessing, D]]		[[Category: Niessing, D]]
	[[Category: Sattler, M]]		[[Category: Sattler, M]]
		+	[[Category: Schlundt, A]]
		+	[[Category: Insulin-like growth factor 2]]
		+	[[Category: Mrna-protein interaction]]
		+	[[Category: Multidomain-rna binding protein]]
		+	[[Category: Rna binding protein]]

OCA at 04:19, 20 June 2018

OCA — Wed, 20 Jun 2018 04:19:57 GMT

←Older revision		Revision as of 04:19, 20 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6gqe is ON HOLD	+	The entry 6gqe is ON HOLD until Paper Publication

	Authors: Janowski, R., Schlundt, A., Sattler, M., Niessing, D.		Authors: Janowski, R., Schlundt, A., Sattler, M., Niessing, D.

OCA: Protected "6gqe" [edit=sysop:move=sysop]

OCA — Thu, 14 Jun 2018 06:01:14 GMT

Protected "6gqe" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:01, 14 June 2018

OCA: New page: '''Unreleased structure''' The entry 6gqe is ON HOLD Authors: Janowski, R., Schlundt, A., Sattler, M., Niessing, D. Description: X-ray structure of KH1-2 domain of IMP3 [[Category: Unr...

OCA — Thu, 14 Jun 2018 06:01:13 GMT

New page: '''Unreleased structure''' The entry 6gqe is ON HOLD Authors: Janowski, R., Schlundt, A., Sattler, M., Niessing, D. Description: X-ray structure of KH1-2 domain of IMP3 [[Category: Unr...

New page

'''Unreleased structure'''

The entry 6gqe is ON HOLD

Authors: Janowski, R., Schlundt, A., Sattler, M., Niessing, D.

Description: X-ray structure of KH1-2 domain of IMP3
[[Category: Unreleased Structures]]
[[Category: Janowski, R]]
[[Category: Schlundt, A]]
[[Category: Niessing, D]]
[[Category: Sattler, M]]