6grs - Revision history

OCA at 10:25, 18 March 2021

OCA — Thu, 18 Mar 2021 10:25:18 GMT

←Older revision		Revision as of 10:25, 18 March 2021
Line 3:		Line 3:
	<StructureSection load='6grs' size='340' side='right'caption='[[6grs]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='6grs' size='340' side='right'caption='[[6grs]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6grs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GRS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6GRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6grs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GRS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pirb, Lilrb3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pirb, Lilrb3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6grs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6grs OCA], [~~http~~://pdbe.org/6grs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6grs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6grs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6grs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6grs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6grs OCA], [https://pdbe.org/6grs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6grs RCSB], [https://www.ebi.ac.uk/pdbsum/6grs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6grs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:14, 3 April 2019

OCA — Wed, 03 Apr 2019 08:14:57 GMT

←Older revision		Revision as of 08:14, 3 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6grs is ~~ON HOLD until Paper~~ Publication	+	==Paired immunoglobulin-like receptor B (PirB) or Leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) full extracellular domain==
		+	<StructureSection load='6grs' size='340' side='right'caption='[[6grs]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6grs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GRS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pirb, Lilrb3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6grs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6grs OCA], [http://pdbe.org/6grs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6grs RCSB], [http://www.ebi.ac.uk/pdbsum/6grs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6grs ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Murine paired immunoglobulin receptor B (PirB) and its human ortholog leukocyte immunoglobulin-like receptor B2 (LILRB2) are widely expressed inhibitory receptors that interact with a diverse set of extracellular ligands and exert functions ranging from down-regulation of immune responses to inhibition of neuronal growth. However, structural information that could shed light on how PirB interacts with its ligands is lacking. Here, we report crystal structures of the PirB ectodomain; the first full ectodomain structure for a LILR family member, at 3.3-4.5 A resolution. The structures reveal that PirB's six Ig-like domains are arranged at acute angles, similar to the structures of leukocyte immunoglobulin-like receptor (LILR) and killer-cell immunoglobulin-like receptor (KIR). We observe that this regular arrangement is followed throughout the ectodomain, resulting in an extended zigzag conformation. In two out of the five structures reported here, the repeating zigzag is broken by the first domain that can adopt two alternative orientations. Quantitative binding experiments revealed a 9 mum dissociation constant for PirB-myelin-associated glycoprotein (MAG) ectodomain interactions. Taken together, these structural findings and the observed PirB-MAG interactions are compatible with a model for intercellular signaling in which the PirB extracellular domains, which point away from the cell surface, enable interaction with ligands in trans.

-	~~Authors: Vlieg, H.C~~., Huizinga, E.G.~~, Janssen, B~~.J.C.	+	Structure and flexibility of the extracellular region of the PirB receptor.,Vlieg HC, Huizinga EG, Janssen BJC J Biol Chem. 2019 Mar 22;294(12):4634-4643. doi: 10.1074/jbc.RA118.004396. Epub, 2019 Jan 23. PMID:30674550<ref>PMID:30674550</ref>

-	~~Description: Paired immunoglobulin~~-~~like receptor B (PirB) or Leukocyte immunoglobulin~~-~~like receptor subfamily B member 3 (LILRB3) full extracellular domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Janssen, B.J.C~~]]	+	<div class="pdbe-citations 6grs" style="background-color:#fffaf0;"></div>
-	[[Category: Huizinga, E.G]]	+	== References ==
-	[[Category: Vlieg, H.C]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
		+	[[Category: Huizinga, E G]]
		+	[[Category: Janssen, B J.C]]
		+	[[Category: Vlieg, H C]]
		+	[[Category: B cell down regulation]]
		+	[[Category: Immune system]]
		+	[[Category: Neuronal growth inhibition]]

OCA at 05:51, 4 July 2018

OCA — Wed, 04 Jul 2018 05:51:30 GMT

←Older revision		Revision as of 05:51, 4 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6grs is ON HOLD	+	The entry 6grs is ON HOLD until Paper Publication

	Authors: Vlieg, H.C., Huizinga, E.G., Janssen, B.J.C.		Authors: Vlieg, H.C., Huizinga, E.G., Janssen, B.J.C.

OCA: Protected "6grs" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2018 04:24:04 GMT

Protected "6grs" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:24, 20 June 2018

OCA: New page: '''Unreleased structure''' The entry 6grs is ON HOLD Authors: Vlieg, H.C., Huizinga, E.G., Janssen, B.J.C. Description: Paired immunoglobulin-like receptor B (PirB) or Leukocyte immuno...

OCA — Wed, 20 Jun 2018 04:24:03 GMT

New page: '''Unreleased structure''' The entry 6grs is ON HOLD Authors: Vlieg, H.C., Huizinga, E.G., Janssen, B.J.C. Description: Paired immunoglobulin-like receptor B (PirB) or Leukocyte immuno...

New page

'''Unreleased structure'''

The entry 6grs is ON HOLD

Authors: Vlieg, H.C., Huizinga, E.G., Janssen, B.J.C.

Description: Paired immunoglobulin-like receptor B (PirB) or Leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) full extracellular domain
[[Category: Unreleased Structures]]
[[Category: Janssen, B.J.C]]
[[Category: Huizinga, E.G]]
[[Category: Vlieg, H.C]]