6gvu - Revision history

OCA at 10:49, 14 June 2023

OCA — Wed, 14 Jun 2023 10:49:26 GMT

←Older revision		Revision as of 10:49, 14 June 2023
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	==NMR structure of the DNA-bound helix bundle domain from the functional pRN1 primase==		==NMR structure of the DNA-bound helix bundle domain from the functional pRN1 primase==
-	<StructureSection load='6gvu' size='340' side='right'caption='[[6gvu~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6gvu' size='340' side='right'caption='[[6gvu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gvu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"sulfolobus_islandicus"_zillig_et_al._1994 "sulfolobus~~ islandicus~~" zillig et al. 1994~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GVU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6GVU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gvu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_islandicus Sulfolobus islandicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GVU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6gvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gvu OCA], [~~http~~://pdbe.org/6gvu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6gvu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6gvu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6gvu ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gvu OCA], [https://pdbe.org/6gvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gvu RCSB], [https://www.ebi.ac.uk/pdbsum/6gvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gvu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q54324_SULIS Q54324_SULIS]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 6gvu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6gvu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Sulfolobus islandicus zillig et al. 1994]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Allain, F H.T~~]]	+	[[Category: Sulfolobus islandicus]]
-	[[Category: ~~Boudet, J~~]]	+	[[Category: Allain FH-T]]
-	[[Category: ~~Lipps, G~~]]	+	[[Category: Boudet J]]
-	[[Category: ~~Dna binding protein]]~~	+	[[Category: Lipps G]]
-	~~[[Category: Primase]]~~	+
-	~~[[Category: Replication initiation]]~~	+
-	~~[[Category: Single-stranded dna~~]]	+

OCA at 13:33, 10 May 2019

OCA — Fri, 10 May 2019 13:33:20 GMT

←Older revision		Revision as of 13:33, 10 May 2019
Line 1:		Line 1:

	==NMR structure of the DNA-bound helix bundle domain from the functional pRN1 primase==		==NMR structure of the DNA-bound helix bundle domain from the functional pRN1 primase==
-	<StructureSection load='6gvu' size='340' side='right' caption='[[6gvu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='6gvu' size='340' side='right'caption='[[6gvu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6gvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"sulfolobus_islandicus"_zillig_et_al._1994 "sulfolobus islandicus" zillig et al. 1994]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GVU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6gvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"sulfolobus_islandicus"_zillig_et_al._1994 "sulfolobus islandicus" zillig et al. 1994]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GVU FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Sulfolobus islandicus zillig et al. 1994]]		[[Category: Sulfolobus islandicus zillig et al. 1994]]
		+	[[Category: Large Structures]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Boudet, J]]		[[Category: Boudet, J]]

OCA at 06:47, 9 January 2019

OCA — Wed, 09 Jan 2019 06:47:40 GMT

←Older revision		Revision as of 06:47, 9 January 2019
Line 3:		Line 3:
	<StructureSection load='6gvu' size='340' side='right' caption='[[6gvu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6gvu' size='340' side='right' caption='[[6gvu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gvu]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GVU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"sulfolobus_islandicus"_zillig_et_al._1994 "sulfolobus islandicus" zillig et al. 1994]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GVU FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gvu OCA], [http://pdbe.org/6gvu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gvu RCSB], [http://www.ebi.ac.uk/pdbsum/6gvu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gvu ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gvu OCA], [http://pdbe.org/6gvu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gvu RCSB], [http://www.ebi.ac.uk/pdbsum/6gvu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gvu ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Primases have a fundamental role in DNA replication. They synthesize a primer that is then extended by DNA polymerases. Archaeoeukaryotic primases require for synthesis a catalytic and an accessory domain, the exact contribution of the latter being unresolved. For the pRN1 archaeal primase, this domain is a 115-amino acid helix bundle domain (HBD). Our structural investigations of this small HBD by liquid- and solid-state nuclear magnetic resonance (NMR) revealed that only the HBD binds the DNA template. DNA binding becomes sequence-specific after a major allosteric change in the HBD, triggered by the binding of two nucleotide triphosphates. The spatial proximity of the two nucleotides and the DNA template in the quaternary structure of the HBD strongly suggests that this small domain brings together the substrates to prepare the first catalytic step of primer synthesis. This efficient mechanism is likely general for all archaeoeukaryotic primases.
		+
		+	A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template.,Boudet J, Devillier JC, Wiegand T, Salmon L, Meier BH, Lipps G, Allain FH Cell. 2018 Dec 18. pii: S0092-8674(18)31556-3. doi: 10.1016/j.cell.2018.11.031. PMID:30595448<ref>PMID:30595448</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6gvu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Sulfolobus islandicus zillig et al. 1994]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Boudet, J]]		[[Category: Boudet, J]]

OCA at 08:20, 26 December 2018

OCA — Wed, 26 Dec 2018 08:20:23 GMT

←Older revision		Revision as of 08:20, 26 December 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6gvu ~~is ON HOLD until Paper Publication~~	+	==NMR structure of the DNA-bound helix bundle domain from the functional pRN1 primase==
-		+	<StructureSection load='6gvu' size='340' side='right' caption='[[6gvu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~: ~~Boudet~~, J., ~~Lipps~~, G., ~~Allain, F~~.H.-T.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6gvu]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GVU FirstGlance]. <br>
-	~~Description: NMR structure of the DNA-bound helix bundle domain from the functional pRN1 primase~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gvu OCA], [http://pdbe.org/6gvu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gvu RCSB], [http://www.ebi.ac.uk/pdbsum/6gvu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gvu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Allain, F H.T]]
	[[Category: Boudet, J]]		[[Category: Boudet, J]]
-	[[Category: Allain, F.H.-T]]
	[[Category: Lipps, G]]		[[Category: Lipps, G]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Primase]]
		+	[[Category: Replication initiation]]
		+	[[Category: Single-stranded dna]]

OCA at 04:07, 24 October 2018

OCA — Wed, 24 Oct 2018 04:07:36 GMT

←Older revision		Revision as of 04:07, 24 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6gvu is ON HOLD	+	The entry 6gvu is ON HOLD until Paper Publication

	Authors: Boudet, J., Lipps, G., Allain, F.H.-T.		Authors: Boudet, J., Lipps, G., Allain, F.H.-T.

OCA: Protected "6gvu" [edit=sysop:move=sysop]

OCA — Wed, 27 Jun 2018 04:19:29 GMT

Protected "6gvu" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 27 June 2018

OCA: New page: '''Unreleased structure''' The entry 6gvu is ON HOLD Authors: Boudet, J., Lipps, G., Allain, F.H.-T. Description: NMR structure of the DNA-bound helix bundle domain from the functional...

OCA — Wed, 27 Jun 2018 04:19:28 GMT

New page: '''Unreleased structure''' The entry 6gvu is ON HOLD Authors: Boudet, J., Lipps, G., Allain, F.H.-T. Description: NMR structure of the DNA-bound helix bundle domain from the functional...

New page

'''Unreleased structure'''

The entry 6gvu is ON HOLD

Authors: Boudet, J., Lipps, G., Allain, F.H.-T.

Description: NMR structure of the DNA-bound helix bundle domain from the functional pRN1 primase
[[Category: Unreleased Structures]]
[[Category: Boudet, J]]
[[Category: Allain, F.H.-T]]
[[Category: Lipps, G]]