6gw5 - Revision history

OCA at 07:20, 31 October 2018

OCA — Wed, 31 Oct 2018 07:20:34 GMT

←Older revision		Revision as of 07:20, 31 October 2018
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	<StructureSection load='6gw5' size='340' side='right' caption='[[6gw5]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='6gw5' size='340' side='right' caption='[[6gw5]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gw5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GW5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gw5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GW5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gw5 OCA], [http://pdbe.org/6gw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gw5 RCSB], [http://www.ebi.ac.uk/pdbsum/6gw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gw5 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">jhp_0662 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gw5 OCA], [http://pdbe.org/6gw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gw5 RCSB], [http://www.ebi.ac.uk/pdbsum/6gw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gw5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 43504]]
	[[Category: Coppens, F]]		[[Category: Coppens, F]]
	[[Category: Remaut, H]]		[[Category: Remaut, H]]

OCA at 07:24, 25 July 2018

OCA — Wed, 25 Jul 2018 07:24:08 GMT

←Older revision		Revision as of 07:24, 25 July 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6gw5 is ~~ON HOLD~~	+	==X-ray structure of the Helicobacter pylori SabA adhesin domain==
		+	<StructureSection load='6gw5' size='340' side='right' caption='[[6gw5]], [[Resolution\|resolution]] 2.52Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6gw5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GW5 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gw5 OCA], [http://pdbe.org/6gw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gw5 RCSB], [http://www.ebi.ac.uk/pdbsum/6gw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gw5 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human stomach pathogen Helicobacter pylori attaches to healthy and inflamed gastric tissue through members of a paralogous family of "Helicobacter outer membrane proteins" (Hops), including adhesins BabA, SabA, HopQ, LabA and HopZ. Hops share a conserved 25 kDa C-terminal region that is thought to form an autotransporter-like transmembrane domain. Instead, our results show that Hops contain a non-continuous transmembrane domain, composed of seven predicted beta-strands at the C-terminus and one at the N-terminus. Folding and outer membrane localization of the C-terminal beta-domain critically depends on a predicted transmembrane beta-strand within the first 16 N-terminal residues. The N-terminus is shown to reside in the periplasm, and our crystal and small angle X-ray scattering structures for the SabA extracellular domain reveal a conserved coiled-coil stem domain that connects to transmembrane beta-strand 1 and 2. Taken together, our data show that Hop adhesins represent a novel outer membrane protein topology encompassing an OmpA-like 8-stranded beta-barrel that is interrupted by a 15 to 108 kDa domain inserted inside the first extracellular loop. The insertion of large, folded domains in an extracellular loop is unprecedented in bacterial outer membrane proteins and is expected to have important consequences on how these proteins reach the cell surface. This article is protected by copyright. All rights reserved.

-	~~Authors: Coppens~~, F., ~~Remaut~~, H.	+	Hop-family Helicobacter outer membrane adhesins form a novel class of Type 5-like secretion proteins with an interrupted beta-barrel domain.,Coppens F, Castaldo G, Debraekeleer A, Subedi S, Moonens K, Lo A, Remaut H Mol Microbiol. 2018 Jul 11. doi: 10.1111/mmi.14075. PMID:29995350<ref>PMID:29995350</ref>

-	~~Description: X-ray structure~~ of the ~~Helicobacter pylori SabA adhesin domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Remaut, H]]~~	+	<div class="pdbe-citations 6gw5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Coppens, F]]		[[Category: Coppens, F]]
		+	[[Category: Remaut, H]]
		+	[[Category: Adhesin]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Lectin]]
		+	[[Category: Lewis x]]
		+	[[Category: Outer membrane protein]]

OCA: Protected "6gw5" [edit=sysop:move=sysop]

OCA — Wed, 27 Jun 2018 04:20:16 GMT

Protected "6gw5" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:20, 27 June 2018

OCA: New page: '''Unreleased structure''' The entry 6gw5 is ON HOLD Authors: Coppens, F., Remaut, H. Description: X-ray structure of the Helicobacter pylori SabA adhesin domain [[Category: Unreleased...

OCA — Wed, 27 Jun 2018 04:20:15 GMT

New page: '''Unreleased structure''' The entry 6gw5 is ON HOLD Authors: Coppens, F., Remaut, H. Description: X-ray structure of the Helicobacter pylori SabA adhesin domain [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 6gw5 is ON HOLD

Authors: Coppens, F., Remaut, H.

Description: X-ray structure of the Helicobacter pylori SabA adhesin domain
[[Category: Unreleased Structures]]
[[Category: Remaut, H]]
[[Category: Coppens, F]]