6gxz - Revision history

OCA at 07:55, 12 September 2018

OCA — Wed, 12 Sep 2018 07:55:56 GMT

←Older revision		Revision as of 07:55, 12 September 2018
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	<StructureSection load='6gxz' size='340' side='right' caption='[[6gxz]], [[Resolution\|resolution]] 2.96Å' scene=''>		<StructureSection load='6gxz' size='340' side='right' caption='[[6gxz]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gxz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GXZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gxz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GXZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RPAP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PIH1D1, NOP17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gxz OCA], [http://pdbe.org/6gxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gxz RCSB], [http://www.ebi.ac.uk/pdbsum/6gxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gxz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gxz OCA], [http://pdbe.org/6gxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gxz RCSB], [http://www.ebi.ac.uk/pdbsum/6gxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gxz ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chagot, M E]]		[[Category: Chagot, M E]]
	[[Category: Charpentier, B]]		[[Category: Charpentier, B]]

OCA at 21:58, 9 August 2018

OCA — Thu, 09 Aug 2018 21:58:38 GMT

←Older revision		Revision as of 21:58, 9 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6gxz is ~~ON HOLD~~	+	==Crystal structure of the human RPAP3(TPR2)-PIH1D1(CS) complex==
		+	<StructureSection load='6gxz' size='340' side='right' caption='[[6gxz]], [[Resolution\|resolution]] 2.96Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6gxz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GXZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gxz OCA], [http://pdbe.org/6gxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gxz RCSB], [http://www.ebi.ac.uk/pdbsum/6gxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gxz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RPAP3_HUMAN RPAP3_HUMAN]] Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.<ref>PMID:17643375</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RPAP3 and PIH1D1 are part of the HSP90 co-chaperone R2TP complex involved in the assembly process of many molecular machines. In this study, we performed a deep structural investigation of the HSP binding abilities of the two TPR domains of RPAP3. We combined 3D NMR, non-denaturing MS, and ITC techniques with Y2H, IP-LUMIER, FRET, and ATPase activity assays and explain the fundamental role played by the second TPR domain of RPAP3 in the specific recruitment of HSP90. We also established the 3D structure of an RPAP3:PIH1D1 sub-complex demonstrating the need for a 34-residue insertion, specific of RPAP3 isoform 1, for the tight binding of PIH1D1. We also confirm the existence of a complex lacking PIH1D1 in human cells (R2T), which shows differential binding to certain clients. These results highlight similarities and differences between the yeast and human R2TP complexes, and document the diversification of this family of co-chaperone complexes in human.

-	~~Authors~~:	+	Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex.,Henri J, Chagot ME, Bourguet M, Abel Y, Terral G, Maurizy C, Aigueperse C, Georgescauld F, Vandermoere F, Saint-Fort R, Behm-Ansmant I, Charpentier B, Pradet-Balade B, Verheggen C, Bertrand E, Meyer P, Cianferani S, Manival X, Quinternet M Structure. 2018 Jul 18. pii: S0969-2126(18)30208-9. doi:, 10.1016/j.str.2018.06.002. PMID:30033218<ref>PMID:30033218</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6gxz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chagot, M E]]
		+	[[Category: Charpentier, B]]
		+	[[Category: Henri, J]]
		+	[[Category: Manival, X]]
		+	[[Category: Meyer, P]]
		+	[[Category: Quinternet, M]]
		+	[[Category: Chaperone]]
		+	[[Category: Cochaperone]]
		+	[[Category: Complex]]
		+	[[Category: Tpr domain]]

OCA: Protected "6gxz" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2018 05:58:34 GMT

Protected "6gxz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 4 July 2018

OCA: New page: '''Unreleased structure''' The entry 6gxz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Jul 2018 05:58:33 GMT

New page: '''Unreleased structure''' The entry 6gxz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6gxz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]