6gy6 - Revision history

OCA at 01:08, 11 April 2020

OCA — Sat, 11 Apr 2020 01:08:08 GMT

←Older revision		Revision as of 01:08, 11 April 2020
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	<SX load='6gy6' size='340' side='right' viewer='molstar' caption='[[6gy6]], [[Resolution\|resolution]] 4.00Å' scene=''>		<SX load='6gy6' size='340' side='right' viewer='molstar' caption='[[6gy6]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gy6]] is a 26 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GY6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6GY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gy6]] is a 26 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GY6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6GY6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6gy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gy6 OCA], [http://pdbe.org/6gy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gy6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gy6 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6gy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gy6 OCA], [http://pdbe.org/6gy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gy6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gy6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:33, 6 March 2020

OCA — Fri, 06 Mar 2020 21:33:39 GMT

←Older revision		Revision as of 21:33, 6 March 2020
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	==XaxAB pore complex from Xenorhabdus nematophila==		==XaxAB pore complex from Xenorhabdus nematophila==
-	<~~StructureSection~~ load='6gy6' size='340' side='right' caption='[[6gy6]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<SX load='6gy6' size='340' side='right' viewer='molstar' caption='[[6gy6]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6gy6]] is a 26 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GY6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6gy6]] is a 26 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GY6 FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
	[[Category: Raunser, S]]		[[Category: Raunser, S]]
	[[Category: Schubert, E]]		[[Category: Schubert, E]]

OCA at 07:24, 25 July 2018

OCA — Wed, 25 Jul 2018 07:24:28 GMT

←Older revision		Revision as of 07:24, 25 July 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6gy6 is ~~ON HOLD~~	+	==XaxAB pore complex from Xenorhabdus nematophila==
		+	<StructureSection load='6gy6' size='340' side='right' caption='[[6gy6]], [[Resolution\|resolution]] 4.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6gy6]] is a 26 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GY6 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gy6 OCA], [http://pdbe.org/6gy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gy6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gy6 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	alpha-Xenorhabdolysins (Xax) are alpha-pore-forming toxins (alpha-PFT) that form 1-1.3 MDa large pore complexes to perforate the host cell membrane. PFTs are used by a variety of bacterial pathogens to attack host cells. Due to the lack of structural information, the molecular mechanism of action of Xax toxins is poorly understood. Here, we report the cryo-EM structure of the XaxAB pore complex from Xenorhabdus nematophila and the crystal structures of the soluble monomers of XaxA and XaxB. The structures reveal that XaxA and XaxB are built similarly and appear as heterodimers in the 12-15 subunits containing pore, classifying XaxAB as bi-component alpha-PFT. Major conformational changes in XaxB, including the swinging out of an amphipathic helix are responsible for membrane insertion. XaxA acts as an activator and stabilizer for XaxB that forms the actual transmembrane pore. Based on our results, we propose a novel structural model for the mechanism of Xax intoxication.

-	~~Authors~~:	+	Membrane insertion of alpha-xenorhabdolysin in near-atomic detail.,Schubert E, Vetter IR, Prumbaum D, Penczek PA, Raunser S Elife. 2018 Jul 16;7. pii: 38017. doi: 10.7554/eLife.38017. PMID:30010541<ref>PMID:30010541</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6gy6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Raunser, S]]
		+	[[Category: Schubert, E]]
		+	[[Category: Bacterial toxin]]
		+	[[Category: Pore forming-toxin]]
		+	[[Category: Toxin]]

OCA: Protected "6gy6" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2018 05:59:24 GMT

Protected "6gy6" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:59, 4 July 2018

OCA: New page: '''Unreleased structure''' The entry 6gy6 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Jul 2018 05:59:23 GMT

New page: '''Unreleased structure''' The entry 6gy6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6gy6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]