6gyo - Revision history

OCA at 01:09, 11 April 2020

OCA — Sat, 11 Apr 2020 01:09:17 GMT

←Older revision		Revision as of 01:09, 11 April 2020
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	<SX load='6gyo' size='340' side='right' viewer='molstar' caption='[[6gyo]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6gyo' size='340' side='right' viewer='molstar' caption='[[6gyo]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gyo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GYO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6GYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gyo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GYO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6GYO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=PIE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL'>PIE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=PIE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL'>PIE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6gyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gyo OCA], [http://pdbe.org/6gyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gyo RCSB], [http://www.ebi.ac.uk/pdbsum/6gyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gyo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6gyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gyo OCA], [http://pdbe.org/6gyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gyo RCSB], [http://www.ebi.ac.uk/pdbsum/6gyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gyo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 21:34, 6 March 2020

OCA — Fri, 06 Mar 2020 21:34:06 GMT

←Older revision		Revision as of 21:34, 6 March 2020
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	==Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP==		==Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP==
-	<~~StructureSection~~ load='6gyo' size='340' side='right'caption='[[6gyo]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<SX load='6gyo' size='340' side='right' viewer='molstar' caption='[[6gyo]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6gyo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6gyo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GYO FirstGlance]. <br>
Line 15:		Line 15:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 10:38, 18 December 2019

OCA — Wed, 18 Dec 2019 10:38:32 GMT

←Older revision		Revision as of 10:38, 18 December 2019
Line 3:		Line 3:
	<StructureSection load='6gyo' size='340' side='right'caption='[[6gyo]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='6gyo' size='340' side='right'caption='[[6gyo]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6gyo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6gyo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GYO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=PIE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL'>PIE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=PIE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL'>PIE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gyo OCA], [http://pdbe.org/6gyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gyo RCSB], [http://www.ebi.ac.uk/pdbsum/6gyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gyo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gyo OCA], [http://pdbe.org/6gyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gyo RCSB], [http://www.ebi.ac.uk/pdbsum/6gyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gyo ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 08:48, 1 May 2019

OCA — Wed, 01 May 2019 08:48:03 GMT

←Older revision		Revision as of 08:48, 1 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~6gyo~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP==
-		+	<StructureSection load='6gyo' size='340' side='right'caption='[[6gyo]], [[Resolution\|resolution]] 3.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6gyo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GYO FirstGlance]. <br>
-	~~Description:~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=PIE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL'>PIE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gyo OCA], [http://pdbe.org/6gyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gyo RCSB], [http://www.ebi.ac.uk/pdbsum/6gyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gyo ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/HCN4_HUMAN HCN4_HUMAN]] Sick sinus syndrome;Brugada syndrome. Sick sinus syndrome 2 (SSS2) [MIM:[http://omim.org/entry/163800 163800]]: The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS2 onset is in utero or at birth. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16407510</ref> <ref>PMID:20662977</ref> Brugada syndrome 8 (BRGDA8) [MIM:[http://omim.org/entry/613123 613123]]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:19165230</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HCN4_HUMAN HCN4_HUMAN]] Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli.<ref>PMID:10228147</ref> <ref>PMID:10430953</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Burgess-Brown, N A]]
		+	[[Category: Bushell, S R]]
		+	[[Category: Carpenter, E P]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Huiskonen, J T]]
		+	[[Category: Mukhopadhyay, S]]
		+	[[Category: Pike, A C.W]]
		+	[[Category: Structural genomic]]
		+	[[Category: Shintre, C A]]
		+	[[Category: Strain-Damerell, C]]
		+	[[Category: Tessitore, A]]
		+	[[Category: Young, M]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Pacemaker current]]

OCA at 14:58, 15 August 2018

OCA — Wed, 15 Aug 2018 14:58:26 GMT

←Older revision		Revision as of 14:58, 15 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6gyo is ON HOLD	+	The entry 6gyo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6gyo" [edit=sysop:move=sysop]

OCA — Wed, 11 Jul 2018 04:15:36 GMT

Protected "6gyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:15, 11 July 2018

OCA: New page: '''Unreleased structure''' The entry 6gyo is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Jul 2018 04:15:35 GMT

New page: '''Unreleased structure''' The entry 6gyo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6gyo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]