OCA at 15:23, 29 January 2020

OCA — Wed, 29 Jan 2020 15:23:46 GMT

←Older revision		Revision as of 15:23, 29 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6h0x is ~~ON HOLD~~	+	==Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA040==
-		+	<StructureSection load='6h0x' size='340' side='right'caption='[[6h0x]], [[Resolution\|resolution]] 1.64Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6h0x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H0X FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FJB:[[(2~{R})-2-(5-phenylpentanoylamino)-2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanoyl]amino]azanium'>FJB</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0x OCA], [http://pdbe.org/6h0x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h0x RCSB], [http://www.ebi.ac.uk/pdbsum/6h0x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0x ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Heinemann, U]]
		+	[[Category: Link, A]]
		+	[[Category: Malecki, P H]]
		+	[[Category: Weiss, M S]]
		+	[[Category: Cancer]]
		+	[[Category: Epigenetic]]
		+	[[Category: Inhibitor design]]
		+	[[Category: Kdm4d]]
		+	[[Category: Ligand binding]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tetrazole]]
		+	[[Category: Tetrazolylhydrazide]]

OCA: Protected "6h0x" [edit=sysop:move=sysop]

OCA — Wed, 18 Jul 2018 05:51:44 GMT

Protected "6h0x" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:51, 18 July 2018

OCA: New page: '''Unreleased structure''' The entry 6h0x is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jul 2018 05:51:40 GMT

New page: '''Unreleased structure''' The entry 6h0x is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6h0x is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6h0x - Revision history

OCA at 15:23, 29 January 2020

OCA: Protected "6h0x" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6h0x is ON HOLD Authors: Description: Category: Unreleased Structures