6h49 - Revision history

OCA at 07:14, 16 October 2019

OCA — Wed, 16 Oct 2019 07:14:39 GMT

←Older revision		Revision as of 07:14, 16 October 2019
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	<StructureSection load='6h49' size='340' side='right'caption='[[6h49]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6h49' size='340' side='right'caption='[[6h49]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6h49]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H49 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6h49]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H49 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h49 OCA], [http://pdbe.org/6h49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h49 RCSB], [http://www.ebi.ac.uk/pdbsum/6h49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h49 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h49 OCA], [http://pdbe.org/6h49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h49 RCSB], [http://www.ebi.ac.uk/pdbsum/6h49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h49 ProSAT]</span></td></tr>

OCA at 15:20, 28 August 2019

OCA — Wed, 28 Aug 2019 15:20:08 GMT

←Older revision		Revision as of 15:20, 28 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6h49 is ~~ON HOLD until Paper~~ Publication	+	==A polyamorous repressor: deciphering the evolutionary strategy used by the phage-inducible chromosomal islands to spread in nature.==
		+	<StructureSection load='6h49' size='340' side='right'caption='[[6h49]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6h49]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H49 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h49 OCA], [http://pdbe.org/6h49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h49 RCSB], [http://www.ebi.ac.uk/pdbsum/6h49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h49 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Stl is a master repressor encoded by Staphylococcus aureus pathogenicity islands (SaPIs) that maintains integration of these elements in the bacterial chromosome. After infection or induction of a resident helper phage, SaPIs are de-repressed by specific interactions of phage proteins with Stl. SaPIs have evolved a fascinating mechanism to ensure their promiscuous transfer by targeting structurally unrelated proteins performing identically conserved functions for the phage. Here we decipher the molecular mechanism of this elegant strategy by determining the structure of SaPIbov1 Stl alone and in complex with two structurally unrelated dUTPases from different S. aureus phages. Remarkably, SaPIbov1 Stl has evolved different domains implicated in DNA and partner recognition specificity. This work presents the solved structure of a SaPI repressor protein and the discovery of a modular repressor that acquires multispecificity through domain recruiting. Our results establish the mechanism that allows widespread dissemination of SaPIs in nature.

-	~~Authors~~:	+	The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature.,Rafael Ciges-Tomas J, Alite C, Humphrey S, Donderis J, Bowring J, Salvatella X, Penades JR, Marina A Nat Commun. 2019 Aug 15;10(1):3676. doi: 10.1038/s41467-019-11504-2. PMID:31417084<ref>PMID:31417084</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6h49" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Alite, C]]
		+	[[Category: Bowring, J Z]]
		+	[[Category: Ciges-Tomas, J R]]
		+	[[Category: Donderis, J]]
		+	[[Category: Marina, A]]
		+	[[Category: Penades, J R]]
		+	[[Category: Repressor]]
		+	[[Category: Sapi]]
		+	[[Category: Structural protein]]

OCA at 20:02, 9 August 2018

OCA — Thu, 09 Aug 2018 20:02:59 GMT

←Older revision		Revision as of 20:02, 9 August 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6h49 is ON HOLD	+	The entry 6h49 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6h49" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2018 17:14:26 GMT

Protected "6h49" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:14, 1 August 2018

OCA: New page: '''Unreleased structure''' The entry 6h49 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Aug 2018 17:14:25 GMT

New page: '''Unreleased structure''' The entry 6h49 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6h49 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]